PDlim2 selectively interacts with the PDZ binding motif of highly pathogenic avian H5N1 influenza A virus NS1.

PDlim2 selectively interacts with the PDZ binding motif of highly pathogenic avian H5N1 influenza A virus NS1.

The multi-functional NS1 protein of influenza A virus is a viral virulence determining factor. The last four residues at the C-terminus of NS1 constitute a type I PDZ domain binding motif (PBM). Avian influenza viruses currently in circulation carry an NS1 PBM with consensus sequence ESEV, whereas h...

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Autores principales: Jia Yu, Xin Li, Yu Wang, Bo Li, Hongyue Li, Yapeng Li, Weihong Zhou, Cuizhu Zhang, Yingying Wang, Zihe Rao, Mark Bartlam, Youjia Cao
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/1990e6c14c284918bff0343c7d359176
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