Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2

Infection of B cells by hepatitis C virus (HCV) is poorly understood, but is thought to result in lymphoproliferative disorders. Here, Chenet al. identify CD86 as co-receptor for lymphotropic HCV and show that HCV infection inhibits memory B-cell function.

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Autores principales:	Chia-Lin Chen, Jeffrey Y. Huang, Chun-Hsiang Wang, Stanley M Tahara, Lin Zhou, Yasuteru Kondo, Joel Schechter, Lishan Su, Michael M C. Lai, Takaji Wakita, François-Loïc Cosset, Jae U Jung, Keigo Machida
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1991ac8957f64473b697653d17ea07e4
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spelling	oai:doaj.org-article:1991ac8957f64473b697653d17ea07e42021-12-02T14:42:41ZHepatitis C virus has a genetically determined lymphotropism through co-receptor B7.210.1038/ncomms138822041-1723https://doaj.org/article/1991ac8957f64473b697653d17ea07e42017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13882https://doaj.org/toc/2041-1723Infection of B cells by hepatitis C virus (HCV) is poorly understood, but is thought to result in lymphoproliferative disorders. Here, Chenet al. identify CD86 as co-receptor for lymphotropic HCV and show that HCV infection inhibits memory B-cell function.Chia-Lin ChenJeffrey Y. HuangChun-Hsiang WangStanley M TaharaLin ZhouYasuteru KondoJoel SchechterLishan SuMichael M C. LaiTakaji WakitaFrançois-Loïc CossetJae U JungKeigo MachidaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chia-Lin Chen Jeffrey Y. Huang Chun-Hsiang Wang Stanley M Tahara Lin Zhou Yasuteru Kondo Joel Schechter Lishan Su Michael M C. Lai Takaji Wakita François-Loïc Cosset Jae U Jung Keigo Machida Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2
description	Infection of B cells by hepatitis C virus (HCV) is poorly understood, but is thought to result in lymphoproliferative disorders. Here, Chenet al. identify CD86 as co-receptor for lymphotropic HCV and show that HCV infection inhibits memory B-cell function.
format	article
author	Chia-Lin Chen Jeffrey Y. Huang Chun-Hsiang Wang Stanley M Tahara Lin Zhou Yasuteru Kondo Joel Schechter Lishan Su Michael M C. Lai Takaji Wakita François-Loïc Cosset Jae U Jung Keigo Machida
author_facet	Chia-Lin Chen Jeffrey Y. Huang Chun-Hsiang Wang Stanley M Tahara Lin Zhou Yasuteru Kondo Joel Schechter Lishan Su Michael M C. Lai Takaji Wakita François-Loïc Cosset Jae U Jung Keigo Machida
author_sort	Chia-Lin Chen
title	Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2
title_short	Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2
title_full	Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2
title_fullStr	Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2
title_full_unstemmed	Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2
title_sort	hepatitis c virus has a genetically determined lymphotropism through co-receptor b7.2
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1991ac8957f64473b697653d17ea07e4
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Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2

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