Kinetic resolution of indolines by asymmetric hydroxylamine formation

Catalytic kinetic resolution of amines is a longstanding challenge in chemical synthesis. Here, the authors report on titanium‐catalysed asymmetric oxygenation with hydrogen peroxide for kinetic resolution of secondary amines through oxygenation to produce enantiopure hydroxylamines involving N–O bo...

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Autores principales: Gang Wang, Ran Lu, Chuangchuang He, Lei Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/199565172e374220bfd17d35397fec04
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Sumario:Catalytic kinetic resolution of amines is a longstanding challenge in chemical synthesis. Here, the authors report on titanium‐catalysed asymmetric oxygenation with hydrogen peroxide for kinetic resolution of secondary amines through oxygenation to produce enantiopure hydroxylamines involving N–O bond formation.