The emerging role of ISWI chromatin remodeling complexes in cancer

Abstract Disordered chromatin remodeling regulation has emerged as an essential driving factor for cancers. Imitation switch (ISWI) family are evolutionarily conserved ATP-dependent chromatin remodeling complexes, which are essential for cellular survival and function through multiple genetic and ep...

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Autores principales:	Yanan Li, Han Gong, Pan Wang, Yu Zhu, Hongling Peng, Yajuan Cui, Heng Li, Jing Liu, Zi Wang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	ISWI family Cofactors Transcription complexes Tumor immunology Inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/1996e52a8be5453980dd1016d7d48a5d
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spelling	oai:doaj.org-article:1996e52a8be5453980dd1016d7d48a5d2021-11-08T10:44:41ZThe emerging role of ISWI chromatin remodeling complexes in cancer10.1186/s13046-021-02151-x1756-9966https://doaj.org/article/1996e52a8be5453980dd1016d7d48a5d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13046-021-02151-xhttps://doaj.org/toc/1756-9966Abstract Disordered chromatin remodeling regulation has emerged as an essential driving factor for cancers. Imitation switch (ISWI) family are evolutionarily conserved ATP-dependent chromatin remodeling complexes, which are essential for cellular survival and function through multiple genetic and epigenetic mechanisms. Omics sequencing and a growing number of basic and clinical studies found that ISWI family members displayed widespread gene expression and genetic status abnormalities in human cancer. Their aberrant expression is closely linked to patient outcome and drug response. Functional or componential alteration in ISWI-containing complexes is critical for tumor initiation and development. Furthermore, ISWI-non-coding RNA regulatory networks and some non-coding RNAs derived from exons of ISWI member genes play important roles in tumor progression. Therefore, unveiling the transcriptional regulation mechanism underlying ISWI family sparked a booming interest in finding ISWI-based therapies in cancer. This review aims at describing the current state-of-the-art in the role of ISWI subunits and complexes in tumorigenesis, tumor progression, immunity and drug response, and presenting deep insight into the physiological and pathological implications of the ISWI transcription machinery in cancers.Yanan LiHan GongPan WangYu ZhuHongling PengYajuan CuiHeng LiJing LiuZi WangBMCarticleISWI familyCofactorsTranscription complexesTumor immunologyInhibitorsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-27 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ISWI family Cofactors Transcription complexes Tumor immunology Inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	ISWI family Cofactors Transcription complexes Tumor immunology Inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yanan Li Han Gong Pan Wang Yu Zhu Hongling Peng Yajuan Cui Heng Li Jing Liu Zi Wang The emerging role of ISWI chromatin remodeling complexes in cancer
description	Abstract Disordered chromatin remodeling regulation has emerged as an essential driving factor for cancers. Imitation switch (ISWI) family are evolutionarily conserved ATP-dependent chromatin remodeling complexes, which are essential for cellular survival and function through multiple genetic and epigenetic mechanisms. Omics sequencing and a growing number of basic and clinical studies found that ISWI family members displayed widespread gene expression and genetic status abnormalities in human cancer. Their aberrant expression is closely linked to patient outcome and drug response. Functional or componential alteration in ISWI-containing complexes is critical for tumor initiation and development. Furthermore, ISWI-non-coding RNA regulatory networks and some non-coding RNAs derived from exons of ISWI member genes play important roles in tumor progression. Therefore, unveiling the transcriptional regulation mechanism underlying ISWI family sparked a booming interest in finding ISWI-based therapies in cancer. This review aims at describing the current state-of-the-art in the role of ISWI subunits and complexes in tumorigenesis, tumor progression, immunity and drug response, and presenting deep insight into the physiological and pathological implications of the ISWI transcription machinery in cancers.
format	article
author	Yanan Li Han Gong Pan Wang Yu Zhu Hongling Peng Yajuan Cui Heng Li Jing Liu Zi Wang
author_facet	Yanan Li Han Gong Pan Wang Yu Zhu Hongling Peng Yajuan Cui Heng Li Jing Liu Zi Wang
author_sort	Yanan Li
title	The emerging role of ISWI chromatin remodeling complexes in cancer
title_short	The emerging role of ISWI chromatin remodeling complexes in cancer
title_full	The emerging role of ISWI chromatin remodeling complexes in cancer
title_fullStr	The emerging role of ISWI chromatin remodeling complexes in cancer
title_full_unstemmed	The emerging role of ISWI chromatin remodeling complexes in cancer
title_sort	emerging role of iswi chromatin remodeling complexes in cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/1996e52a8be5453980dd1016d7d48a5d
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The emerging role of ISWI chromatin remodeling complexes in cancer

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