Antiplasmodial potential of Eucalyptus obliqua leaf methanolic extract against Plasmodium vivax: An in vitro study

Malaria is an intraerythrocytic parasitic disease caused by the genus Plasmodium of which Plasmodium vivax and Plasmodium falciparum are the major species. The high cost and associated side effects of antimalarial drugs triggered research about medicinal plants to develop alternative and low-cost dr...

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Autores principales:	Zareen Shehzad, Khan Shahid Niaz, Adnan Muhammad, Haleem Sumbal, Ali Rehman, Alnomasy Sultan F.
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	plasmodium vivax eucalyptus obliqua antiplasmodial activity in vitro Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/19976b177f3c435dbfbfd3fd1d5c6c1f
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spelling	oai:doaj.org-article:19976b177f3c435dbfbfd3fd1d5c6c1f2021-12-05T14:10:44ZAntiplasmodial potential of Eucalyptus obliqua leaf methanolic extract against Plasmodium vivax: An in vitro study2391-542010.1515/chem-2021-0091https://doaj.org/article/19976b177f3c435dbfbfd3fd1d5c6c1f2021-09-01T00:00:00Zhttps://doi.org/10.1515/chem-2021-0091https://doaj.org/toc/2391-5420Malaria is an intraerythrocytic parasitic disease caused by the genus Plasmodium of which Plasmodium vivax and Plasmodium falciparum are the major species. The high cost and associated side effects of antimalarial drugs triggered research about medicinal plants to develop alternative and low-cost drugs with lesser side effects. Therefore, this study was designed to investigate the antiplasmodial activity of the Eucalyptus obliqua L’Hér. leaf extract against P. vivax and its phytochemicals in in vitro. The methanolic extract of E. obliqua was prepared and different concentrations of the crude extract and phytochemicals were used against P. vivax. The methanolic extract of E. obliqua showed profound antiplasmodial activity (LD50 0.084 mg/mL; 80.04%) at 0.1 mg/mL concentration after 24 h. Alkaloids, flavonoids, saponins, and tannins were found in the E. obliqua methanolic extract. Only alkaloids at the concentration (0.1 mg/mL) exhibited 60.93% inhibition of P. vivax. The methanolic extract of E. obliqua exhibits antiplasmodial activity in vitro. However, in vivo efficacy is an important aspect in the testing of medicinal plants against parasitic infections and should be evaluated in future.Zareen ShehzadKhan Shahid NiazAdnan MuhammadHaleem SumbalAli RehmanAlnomasy Sultan F.De Gruyterarticleplasmodium vivaxeucalyptus obliquaantiplasmodial activityin vitroChemistryQD1-999ENOpen Chemistry, Vol 19, Iss 1, Pp 1023-1028 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	plasmodium vivax eucalyptus obliqua antiplasmodial activity in vitro Chemistry QD1-999
spellingShingle	plasmodium vivax eucalyptus obliqua antiplasmodial activity in vitro Chemistry QD1-999 Zareen Shehzad Khan Shahid Niaz Adnan Muhammad Haleem Sumbal Ali Rehman Alnomasy Sultan F. Antiplasmodial potential of Eucalyptus obliqua leaf methanolic extract against Plasmodium vivax: An in vitro study
description	Malaria is an intraerythrocytic parasitic disease caused by the genus Plasmodium of which Plasmodium vivax and Plasmodium falciparum are the major species. The high cost and associated side effects of antimalarial drugs triggered research about medicinal plants to develop alternative and low-cost drugs with lesser side effects. Therefore, this study was designed to investigate the antiplasmodial activity of the Eucalyptus obliqua L’Hér. leaf extract against P. vivax and its phytochemicals in in vitro. The methanolic extract of E. obliqua was prepared and different concentrations of the crude extract and phytochemicals were used against P. vivax. The methanolic extract of E. obliqua showed profound antiplasmodial activity (LD50 0.084 mg/mL; 80.04%) at 0.1 mg/mL concentration after 24 h. Alkaloids, flavonoids, saponins, and tannins were found in the E. obliqua methanolic extract. Only alkaloids at the concentration (0.1 mg/mL) exhibited 60.93% inhibition of P. vivax. The methanolic extract of E. obliqua exhibits antiplasmodial activity in vitro. However, in vivo efficacy is an important aspect in the testing of medicinal plants against parasitic infections and should be evaluated in future.
format	article
author	Zareen Shehzad Khan Shahid Niaz Adnan Muhammad Haleem Sumbal Ali Rehman Alnomasy Sultan F.
author_facet	Zareen Shehzad Khan Shahid Niaz Adnan Muhammad Haleem Sumbal Ali Rehman Alnomasy Sultan F.
author_sort	Zareen Shehzad
title	Antiplasmodial potential of Eucalyptus obliqua leaf methanolic extract against Plasmodium vivax: An in vitro study
title_short	Antiplasmodial potential of Eucalyptus obliqua leaf methanolic extract against Plasmodium vivax: An in vitro study
title_full	Antiplasmodial potential of Eucalyptus obliqua leaf methanolic extract against Plasmodium vivax: An in vitro study
title_fullStr	Antiplasmodial potential of Eucalyptus obliqua leaf methanolic extract against Plasmodium vivax: An in vitro study
title_full_unstemmed	Antiplasmodial potential of Eucalyptus obliqua leaf methanolic extract against Plasmodium vivax: An in vitro study
title_sort	antiplasmodial potential of eucalyptus obliqua leaf methanolic extract against plasmodium vivax: an in vitro study
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/19976b177f3c435dbfbfd3fd1d5c6c1f
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Antiplasmodial potential of Eucalyptus obliqua leaf methanolic extract against Plasmodium vivax: An in vitro study

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