Characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species

Abstract Phototherapy using light-emitting diodes (LEDs) centered on the green spectrum, which has a high cyclobilirubin production rate, was as effective as that centered on the blue spectrum for neonatal hyperbilirubinemia. There are no reports of species differences in bilirubin photochemical cha...

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Autores principales:	Kohichiroh Nii, Hitoshi Okada, Susumu Itoh, Takashi Kusaka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/199a68d7149942b0b28fce7cec2666e0
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spelling	oai:doaj.org-article:199a68d7149942b0b28fce7cec2666e02021-12-02T13:18:08ZCharacteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species10.1038/s41598-021-85632-52045-2322https://doaj.org/article/199a68d7149942b0b28fce7cec2666e02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85632-5https://doaj.org/toc/2045-2322Abstract Phototherapy using light-emitting diodes (LEDs) centered on the green spectrum, which has a high cyclobilirubin production rate, was as effective as that centered on the blue spectrum for neonatal hyperbilirubinemia. There are no reports of species differences in bilirubin photochemical changes in this spectrum, and the characteristics of bilirubin photochemical changes in humans must be elucidated to proceed with the development of new light sources that include these spectra. This report describes the characteristic photochemical kinetics of bilirubin under green-spectrum LEDs in human, rat, rabbit, dog, pig, sheep, bovine and chicken serum albumin and rhesus monkey serum. These albumin-bilirubin complex solutions were irradiated by green LEDs, and the time-course changes in bilirubin photoisomers were measured by high-performance liquid chromatography. The cyclobilirubin production rates in humans, pigs, and monkeys were significantly higher than those in other species. The rate constant of (EZ)-cyclobilirubin production from (EZ)-bilirubin ‘k’ was significantly higher in humans and monkeys than in other species. In conclusion, bilirubin photochemical kinetics under green spectrum LEDs in humans were characterized by a high cyclobilirubin production rate at a low substrate concentration. The bilirubin photochemical kinetics in monkeys were similar to those in humans.Kohichiroh NiiHitoshi OkadaSusumu ItohTakashi KusakaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kohichiroh Nii Hitoshi Okada Susumu Itoh Takashi Kusaka Characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species
description	Abstract Phototherapy using light-emitting diodes (LEDs) centered on the green spectrum, which has a high cyclobilirubin production rate, was as effective as that centered on the blue spectrum for neonatal hyperbilirubinemia. There are no reports of species differences in bilirubin photochemical changes in this spectrum, and the characteristics of bilirubin photochemical changes in humans must be elucidated to proceed with the development of new light sources that include these spectra. This report describes the characteristic photochemical kinetics of bilirubin under green-spectrum LEDs in human, rat, rabbit, dog, pig, sheep, bovine and chicken serum albumin and rhesus monkey serum. These albumin-bilirubin complex solutions were irradiated by green LEDs, and the time-course changes in bilirubin photoisomers were measured by high-performance liquid chromatography. The cyclobilirubin production rates in humans, pigs, and monkeys were significantly higher than those in other species. The rate constant of (EZ)-cyclobilirubin production from (EZ)-bilirubin ‘k’ was significantly higher in humans and monkeys than in other species. In conclusion, bilirubin photochemical kinetics under green spectrum LEDs in humans were characterized by a high cyclobilirubin production rate at a low substrate concentration. The bilirubin photochemical kinetics in monkeys were similar to those in humans.
format	article
author	Kohichiroh Nii Hitoshi Okada Susumu Itoh Takashi Kusaka
author_facet	Kohichiroh Nii Hitoshi Okada Susumu Itoh Takashi Kusaka
author_sort	Kohichiroh Nii
title	Characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species
title_short	Characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species
title_full	Characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species
title_fullStr	Characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species
title_full_unstemmed	Characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species
title_sort	characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/199a68d7149942b0b28fce7cec2666e0
work_keys_str_mv	AT kohichirohnii characteristicsofbilirubinphotochemicalchangesundergreenlightemittingdiodesinhumanscomparedwithanimalspecies AT hitoshiokada characteristicsofbilirubinphotochemicalchangesundergreenlightemittingdiodesinhumanscomparedwithanimalspecies AT susumuitoh characteristicsofbilirubinphotochemicalchangesundergreenlightemittingdiodesinhumanscomparedwithanimalspecies AT takashikusaka characteristicsofbilirubinphotochemicalchangesundergreenlightemittingdiodesinhumanscomparedwithanimalspecies
_version_	1718393257018261504

Characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species

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