Meteorological Factors Influence the Presence of Fungi in the Air; A 14-Month Surveillance Study at an Adult Cystic Fibrosis Center
BackgroundCystic fibrosis is an inherited disease that predisposes to progressive lung damage. Cystic fibrosis patients are particularly prone to developing pulmonary infections. Fungal species are commonly isolated in lower airway samples from patients with cystic fibrosis. Fungal spores are preval...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:199cce51ff77495e9a0b12ed675a72882021-12-01T07:22:48ZMeteorological Factors Influence the Presence of Fungi in the Air; A 14-Month Surveillance Study at an Adult Cystic Fibrosis Center2235-298810.3389/fcimb.2021.759944https://doaj.org/article/199cce51ff77495e9a0b12ed675a72882021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.759944/fullhttps://doaj.org/toc/2235-2988BackgroundCystic fibrosis is an inherited disease that predisposes to progressive lung damage. Cystic fibrosis patients are particularly prone to developing pulmonary infections. Fungal species are commonly isolated in lower airway samples from patients with cystic fibrosis. Fungal spores are prevalent in the air.MethodsWe performed environmental air sampling surveillance at the Manchester Adult Cystic Fibrosis Centre, UK (MACFC) over a 14-month period to assess fungal growth inside and outside the CF center.ResultsAirborne counts of fungal spores peaked from May to October, both in outdoor and indoor samples. Collection of meteorological data allowed us to correlate fungal presence in the air with elevated temperatures and low wind speeds. Additionally, we demonstrated patient rooms containing windows had elevated fungal counts compared to rooms not directly connected to the outdoors.ConclusionsThis study suggests that airborne Aspergillus fumigatus spores were more abundant during the summer months of the survey period, which appeared to be driven by increased temperatures and lower wind speeds. Indoor counts directly correlated to outdoor A. fumigatus levels and were elevated in patient rooms that were directly connected to the outdoor environment via an openable window designed for ventilation purposes. Further studies are required to determine the clinical implications of these findings for cystic fibrosis patients who are predisposed to Aspergillus related diseases, and in particular whether there is seasonal influence on incidence of Aspergillus related conditions and if screening for such complications such be increased during summer months and precautions intensified for those with a known history of Aspergillus related disease.Norman van RhijnJames ColemanJames ColemanLisa CollierLisa CollierCaroline MooreCaroline MooreMalcolm D. RichardsonMalcolm D. RichardsonRowland J. Bright-ThomasRowland J. Bright-ThomasAndrew M. JonesAndrew M. JonesAndrew M. JonesFrontiers Media S.A.articleAspergillus fumigatusPenicilliumfungiair samplingtemperaturecystic fibrosisMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Aspergillus fumigatus Penicillium fungi air sampling temperature cystic fibrosis Microbiology QR1-502 |
| spellingShingle |
Aspergillus fumigatus Penicillium fungi air sampling temperature cystic fibrosis Microbiology QR1-502 Norman van Rhijn James Coleman James Coleman Lisa Collier Lisa Collier Caroline Moore Caroline Moore Malcolm D. Richardson Malcolm D. Richardson Rowland J. Bright-Thomas Rowland J. Bright-Thomas Andrew M. Jones Andrew M. Jones Andrew M. Jones Meteorological Factors Influence the Presence of Fungi in the Air; A 14-Month Surveillance Study at an Adult Cystic Fibrosis Center |
| description |
BackgroundCystic fibrosis is an inherited disease that predisposes to progressive lung damage. Cystic fibrosis patients are particularly prone to developing pulmonary infections. Fungal species are commonly isolated in lower airway samples from patients with cystic fibrosis. Fungal spores are prevalent in the air.MethodsWe performed environmental air sampling surveillance at the Manchester Adult Cystic Fibrosis Centre, UK (MACFC) over a 14-month period to assess fungal growth inside and outside the CF center.ResultsAirborne counts of fungal spores peaked from May to October, both in outdoor and indoor samples. Collection of meteorological data allowed us to correlate fungal presence in the air with elevated temperatures and low wind speeds. Additionally, we demonstrated patient rooms containing windows had elevated fungal counts compared to rooms not directly connected to the outdoors.ConclusionsThis study suggests that airborne Aspergillus fumigatus spores were more abundant during the summer months of the survey period, which appeared to be driven by increased temperatures and lower wind speeds. Indoor counts directly correlated to outdoor A. fumigatus levels and were elevated in patient rooms that were directly connected to the outdoor environment via an openable window designed for ventilation purposes. Further studies are required to determine the clinical implications of these findings for cystic fibrosis patients who are predisposed to Aspergillus related diseases, and in particular whether there is seasonal influence on incidence of Aspergillus related conditions and if screening for such complications such be increased during summer months and precautions intensified for those with a known history of Aspergillus related disease. |
| format |
article |
| author |
Norman van Rhijn James Coleman James Coleman Lisa Collier Lisa Collier Caroline Moore Caroline Moore Malcolm D. Richardson Malcolm D. Richardson Rowland J. Bright-Thomas Rowland J. Bright-Thomas Andrew M. Jones Andrew M. Jones Andrew M. Jones |
| author_facet |
Norman van Rhijn James Coleman James Coleman Lisa Collier Lisa Collier Caroline Moore Caroline Moore Malcolm D. Richardson Malcolm D. Richardson Rowland J. Bright-Thomas Rowland J. Bright-Thomas Andrew M. Jones Andrew M. Jones Andrew M. Jones |
| author_sort |
Norman van Rhijn |
| title |
Meteorological Factors Influence the Presence of Fungi in the Air; A 14-Month Surveillance Study at an Adult Cystic Fibrosis Center |
| title_short |
Meteorological Factors Influence the Presence of Fungi in the Air; A 14-Month Surveillance Study at an Adult Cystic Fibrosis Center |
| title_full |
Meteorological Factors Influence the Presence of Fungi in the Air; A 14-Month Surveillance Study at an Adult Cystic Fibrosis Center |
| title_fullStr |
Meteorological Factors Influence the Presence of Fungi in the Air; A 14-Month Surveillance Study at an Adult Cystic Fibrosis Center |
| title_full_unstemmed |
Meteorological Factors Influence the Presence of Fungi in the Air; A 14-Month Surveillance Study at an Adult Cystic Fibrosis Center |
| title_sort |
meteorological factors influence the presence of fungi in the air; a 14-month surveillance study at an adult cystic fibrosis center |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/199cce51ff77495e9a0b12ed675a7288 |
| work_keys_str_mv |
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