Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease.

Neuritin, also known as CPG15, is a neurotrophic factor that was initially discovered in a screen to identify genes involved in activity-dependent synaptic plasticity. Neuritin plays multiple roles in the process of neural development and synaptic plasticity, although its binding receptor(s) and dow...

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Autores principales:	Yoori Choi, Kihwan Lee, Junghwa Ryu, Hyoun Geun Kim, A Young Jeong, Ran-Sook Woo, Jun-Ho Lee, Jin Won Hyun, Seokyung Hahn, Joung-Hun Kim, Hye-Sun Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/199d6cdb582e4652ba44e6747c74e1b8
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spelling	oai:doaj.org-article:199d6cdb582e4652ba44e6747c74e1b82021-11-25T06:05:40ZNeuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease.1932-620310.1371/journal.pone.0104121https://doaj.org/article/199d6cdb582e4652ba44e6747c74e1b82014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25101829/?tool=EBIhttps://doaj.org/toc/1932-6203Neuritin, also known as CPG15, is a neurotrophic factor that was initially discovered in a screen to identify genes involved in activity-dependent synaptic plasticity. Neuritin plays multiple roles in the process of neural development and synaptic plasticity, although its binding receptor(s) and downstream signaling effectors remain unclear. In this study, we found that the cortical and hippocampal expression of neuritin is reduced in the brains of Alzheimer's disease (AD) patients and demonstrated that viral-mediated expression of neuritin in the dentate gyrus of 13-month-old Tg2576 mice, an AD animal model, attenuated a deficit in learning and memory as assessed by a Morris water maze test. We also found that neuritin restored the reduction in dendritic spine density and the maturity of individual spines in primary hippocampal neuron cultures prepared from Tg2576 mice. It was also shown that viral-mediated expression of neuritin in the dentate gyrus of 7-week-old Sprague-Dawley rats increased neurogenesis in the hippocampus. Taken together, our results demonstrate that neuritin restores the reduction in dendritic spine density and the maturity of individual spines in primary hippocampal neurons from Tg2576 neurons, and also attenuates cognitive function deficits in Tg2576 mouse model of AD, suggesting that neuritin possesses a therapeutic potential for AD.Yoori ChoiKihwan LeeJunghwa RyuHyoun Geun KimA Young JeongRan-Sook WooJun-Ho LeeJin Won HyunSeokyung HahnJoung-Hun KimHye-Sun KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e104121 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoori Choi Kihwan Lee Junghwa Ryu Hyoun Geun Kim A Young Jeong Ran-Sook Woo Jun-Ho Lee Jin Won Hyun Seokyung Hahn Joung-Hun Kim Hye-Sun Kim Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease.
description	Neuritin, also known as CPG15, is a neurotrophic factor that was initially discovered in a screen to identify genes involved in activity-dependent synaptic plasticity. Neuritin plays multiple roles in the process of neural development and synaptic plasticity, although its binding receptor(s) and downstream signaling effectors remain unclear. In this study, we found that the cortical and hippocampal expression of neuritin is reduced in the brains of Alzheimer's disease (AD) patients and demonstrated that viral-mediated expression of neuritin in the dentate gyrus of 13-month-old Tg2576 mice, an AD animal model, attenuated a deficit in learning and memory as assessed by a Morris water maze test. We also found that neuritin restored the reduction in dendritic spine density and the maturity of individual spines in primary hippocampal neuron cultures prepared from Tg2576 mice. It was also shown that viral-mediated expression of neuritin in the dentate gyrus of 7-week-old Sprague-Dawley rats increased neurogenesis in the hippocampus. Taken together, our results demonstrate that neuritin restores the reduction in dendritic spine density and the maturity of individual spines in primary hippocampal neurons from Tg2576 neurons, and also attenuates cognitive function deficits in Tg2576 mouse model of AD, suggesting that neuritin possesses a therapeutic potential for AD.
format	article
author	Yoori Choi Kihwan Lee Junghwa Ryu Hyoun Geun Kim A Young Jeong Ran-Sook Woo Jun-Ho Lee Jin Won Hyun Seokyung Hahn Joung-Hun Kim Hye-Sun Kim
author_facet	Yoori Choi Kihwan Lee Junghwa Ryu Hyoun Geun Kim A Young Jeong Ran-Sook Woo Jun-Ho Lee Jin Won Hyun Seokyung Hahn Joung-Hun Kim Hye-Sun Kim
author_sort	Yoori Choi
title	Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease.
title_short	Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease.
title_full	Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease.
title_fullStr	Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease.
title_full_unstemmed	Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease.
title_sort	neuritin attenuates cognitive function impairments in tg2576 mouse model of alzheimer's disease.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/199d6cdb582e4652ba44e6747c74e1b8
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Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease.

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