Advances of microneedles in hormone delivery

The skin is recognized as a potential target for local and systemic drug delivery and hormone. However, the transdermal route of drug administration seems to be limited by substantial barrier properties of the skin. Recently, delivering hormone via the skin by transdermal patches is a big challenge...

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Autores principales:	Thuy Trang Nguyen, Thi Thuy Dung Nguyen, Nguyen-Minh-An Tran, Giau Van Vo
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Microneedle Transdermal Hormone Delivery, skin Non-invasive Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/199e90d8d582442b8bb554ffaf653d98
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spelling	oai:doaj.org-article:199e90d8d582442b8bb554ffaf653d982021-11-12T04:25:27ZAdvances of microneedles in hormone delivery0753-332210.1016/j.biopha.2021.112393https://doaj.org/article/199e90d8d582442b8bb554ffaf653d982022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011793https://doaj.org/toc/0753-3322The skin is recognized as a potential target for local and systemic drug delivery and hormone. However, the transdermal route of drug administration seems to be limited by substantial barrier properties of the skin. Recently, delivering hormone via the skin by transdermal patches is a big challenge because of the presence of the stratum corneum that prevents the application of hormone via this route. In order to overcome the limitations, microneedle (MN), consisting of micro-sized needles, are a promising approach to drill the stratum corneum and release hormone into the dermis via a minimal-invasive route. This review aimed to highlight advances in research on the development of MNs-based therapeutics for their implications in hormone delivery. The challenges during clinical translation of MNs from bench to bedside are also discussed.Thuy Trang NguyenThi Thuy Dung NguyenNguyen-Minh-An TranGiau Van VoElsevierarticleMicroneedleTransdermalHormoneDelivery, skinNon-invasiveTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112393- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microneedle Transdermal Hormone Delivery, skin Non-invasive Therapeutics. Pharmacology RM1-950
spellingShingle	Microneedle Transdermal Hormone Delivery, skin Non-invasive Therapeutics. Pharmacology RM1-950 Thuy Trang Nguyen Thi Thuy Dung Nguyen Nguyen-Minh-An Tran Giau Van Vo Advances of microneedles in hormone delivery
description	The skin is recognized as a potential target for local and systemic drug delivery and hormone. However, the transdermal route of drug administration seems to be limited by substantial barrier properties of the skin. Recently, delivering hormone via the skin by transdermal patches is a big challenge because of the presence of the stratum corneum that prevents the application of hormone via this route. In order to overcome the limitations, microneedle (MN), consisting of micro-sized needles, are a promising approach to drill the stratum corneum and release hormone into the dermis via a minimal-invasive route. This review aimed to highlight advances in research on the development of MNs-based therapeutics for their implications in hormone delivery. The challenges during clinical translation of MNs from bench to bedside are also discussed.
format	article
author	Thuy Trang Nguyen Thi Thuy Dung Nguyen Nguyen-Minh-An Tran Giau Van Vo
author_facet	Thuy Trang Nguyen Thi Thuy Dung Nguyen Nguyen-Minh-An Tran Giau Van Vo
author_sort	Thuy Trang Nguyen
title	Advances of microneedles in hormone delivery
title_short	Advances of microneedles in hormone delivery
title_full	Advances of microneedles in hormone delivery
title_fullStr	Advances of microneedles in hormone delivery
title_full_unstemmed	Advances of microneedles in hormone delivery
title_sort	advances of microneedles in hormone delivery
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/199e90d8d582442b8bb554ffaf653d98
work_keys_str_mv	AT thuytrangnguyen advancesofmicroneedlesinhormonedelivery AT thithuydungnguyen advancesofmicroneedlesinhormonedelivery AT nguyenminhantran advancesofmicroneedlesinhormonedelivery AT giauvanvo advancesofmicroneedlesinhormonedelivery
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Advances of microneedles in hormone delivery

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