Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism

Aberrant gene expression in cancer coincides with drastic changes in metabolism. Here, the authors combined metabolome, transcriptome and proteome data in 54 cancer cell lines to uncover a genome-scale network of associations between transcriptional regulators and metabolites.

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Autores principales: Karin Ortmayr, Sébastien Dubuis, Mattia Zampieri
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/19a0aeae043341178fd7a04d59da82b2
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spelling oai:doaj.org-article:19a0aeae043341178fd7a04d59da82b22021-12-02T14:38:38ZMetabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism10.1038/s41467-019-09695-92041-1723https://doaj.org/article/19a0aeae043341178fd7a04d59da82b22019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09695-9https://doaj.org/toc/2041-1723Aberrant gene expression in cancer coincides with drastic changes in metabolism. Here, the authors combined metabolome, transcriptome and proteome data in 54 cancer cell lines to uncover a genome-scale network of associations between transcriptional regulators and metabolites.Karin OrtmayrSébastien DubuisMattia ZampieriNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Karin Ortmayr
Sébastien Dubuis
Mattia Zampieri
Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
description Aberrant gene expression in cancer coincides with drastic changes in metabolism. Here, the authors combined metabolome, transcriptome and proteome data in 54 cancer cell lines to uncover a genome-scale network of associations between transcriptional regulators and metabolites.
format article
author Karin Ortmayr
Sébastien Dubuis
Mattia Zampieri
author_facet Karin Ortmayr
Sébastien Dubuis
Mattia Zampieri
author_sort Karin Ortmayr
title Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
title_short Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
title_full Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
title_fullStr Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
title_full_unstemmed Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
title_sort metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/19a0aeae043341178fd7a04d59da82b2
work_keys_str_mv AT karinortmayr metabolicprofilingofcancercellsrevealsgenomewidecrosstalkbetweentranscriptionalregulatorsandmetabolism
AT sebastiendubuis metabolicprofilingofcancercellsrevealsgenomewidecrosstalkbetweentranscriptionalregulatorsandmetabolism
AT mattiazampieri metabolicprofilingofcancercellsrevealsgenomewidecrosstalkbetweentranscriptionalregulatorsandmetabolism
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