Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism

Aberrant gene expression in cancer coincides with drastic changes in metabolism. Here, the authors combined metabolome, transcriptome and proteome data in 54 cancer cell lines to uncover a genome-scale network of associations between transcriptional regulators and metabolites.

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Détails bibliographiques
Auteurs principaux:	Karin Ortmayr, Sébastien Dubuis, Mattia Zampieri
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/19a0aeae043341178fd7a04d59da82b2
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spelling	oai:doaj.org-article:19a0aeae043341178fd7a04d59da82b22021-12-02T14:38:38ZMetabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism10.1038/s41467-019-09695-92041-1723https://doaj.org/article/19a0aeae043341178fd7a04d59da82b22019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09695-9https://doaj.org/toc/2041-1723Aberrant gene expression in cancer coincides with drastic changes in metabolism. Here, the authors combined metabolome, transcriptome and proteome data in 54 cancer cell lines to uncover a genome-scale network of associations between transcriptional regulators and metabolites.Karin OrtmayrSébastien DubuisMattia ZampieriNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karin Ortmayr Sébastien Dubuis Mattia Zampieri Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
description	Aberrant gene expression in cancer coincides with drastic changes in metabolism. Here, the authors combined metabolome, transcriptome and proteome data in 54 cancer cell lines to uncover a genome-scale network of associations between transcriptional regulators and metabolites.
format	article
author	Karin Ortmayr Sébastien Dubuis Mattia Zampieri
author_facet	Karin Ortmayr Sébastien Dubuis Mattia Zampieri
author_sort	Karin Ortmayr
title	Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
title_short	Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
title_full	Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
title_fullStr	Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
title_full_unstemmed	Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
title_sort	metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/19a0aeae043341178fd7a04d59da82b2
work_keys_str_mv	AT karinortmayr metabolicprofilingofcancercellsrevealsgenomewidecrosstalkbetweentranscriptionalregulatorsandmetabolism AT sebastiendubuis metabolicprofilingofcancercellsrevealsgenomewidecrosstalkbetweentranscriptionalregulatorsandmetabolism AT mattiazampieri metabolicprofilingofcancercellsrevealsgenomewidecrosstalkbetweentranscriptionalregulatorsandmetabolism
_version_	1718390877383032832

Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism

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