Curcumin ameliorates gestational diabetes in mice partly through activating AMPK

Context: In vitro and in vivo research has shown that curcumin can alleviate diabetes and the relevant complications. Objective: To investigate the effect of curcumin on gestational diabetes (GD). Materials and methods: C57 BL/KsJdb/+(db/+) mice and C57 BL/KsJ+/+ mice (10–12 weeks old) were divided...

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Autores principales:	Xuehong Lu, Fei Wu, Mengxue Jiang, Xiujuan Sun, Geng Tian
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	gsh sod cat ampk hdac4 glucose-6-phosphatase Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/19a1b375a69a458588d282f1b7ae09ec
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spelling	oai:doaj.org-article:19a1b375a69a458588d282f1b7ae09ec2021-11-17T14:21:56ZCurcumin ameliorates gestational diabetes in mice partly through activating AMPK1388-02091744-511610.1080/13880209.2019.1594311https://doaj.org/article/19a1b375a69a458588d282f1b7ae09ec2019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2019.1594311https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: In vitro and in vivo research has shown that curcumin can alleviate diabetes and the relevant complications. Objective: To investigate the effect of curcumin on gestational diabetes (GD). Materials and methods: C57 BL/KsJdb/+(db/+) mice and C57 BL/KsJ+/+ mice (10–12 weeks old) were divided into four groups (n = 15): normal pregnancy (C57 BL/KsJ+/+), GD (C57 BL/KsJdb/+), GD plus low dose curcumin (50 mg/kg, orally gavage every day) and GD plus high dose curcumin (100 mg/kg, orally gavage every day). The tolerance of glucose and insulin were measured on gestation day 10. Body weight at birth and litter size of offspring were investigated, and the expression of oxidative stress factors [thiobarbituric acid reactive substance (TBARS), glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT)] and AMP-activated protein kinase (AMPK), phospho-AMPK, histone deacetylases 4 (HDAC4), pHDAC4 and glucose-6-phosphatase (G6Pase) in the livers were analyzed by ELISA and Western blot on gestation day 20. Results: High dose curcumin could partly ameliorate the intolerance of glucose and insulin, and completely restore the litter size and the body weight of GD mice through decreased TBARS expression (p < 0.05) and increased GSH, SOD and CAT expression (p < 0.05). Enhanced AMPK activation, accompanied with decreased HDAC4 and G6Pase expression (p < 0.05) were partly contributed to the alleviation of GD mediated by curcumin. Conclusions: Although further detailed mechanism needs to be deciphered, curcumin can be considered as an alternative treatment for gestational diabetes.Xuehong LuFei WuMengxue JiangXiujuan SunGeng TianTaylor & Francis Grouparticlegshsodcatampkhdac4glucose-6-phosphataseTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 250-254 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	gsh sod cat ampk hdac4 glucose-6-phosphatase Therapeutics. Pharmacology RM1-950
spellingShingle	gsh sod cat ampk hdac4 glucose-6-phosphatase Therapeutics. Pharmacology RM1-950 Xuehong Lu Fei Wu Mengxue Jiang Xiujuan Sun Geng Tian Curcumin ameliorates gestational diabetes in mice partly through activating AMPK
description	Context: In vitro and in vivo research has shown that curcumin can alleviate diabetes and the relevant complications. Objective: To investigate the effect of curcumin on gestational diabetes (GD). Materials and methods: C57 BL/KsJdb/+(db/+) mice and C57 BL/KsJ+/+ mice (10–12 weeks old) were divided into four groups (n = 15): normal pregnancy (C57 BL/KsJ+/+), GD (C57 BL/KsJdb/+), GD plus low dose curcumin (50 mg/kg, orally gavage every day) and GD plus high dose curcumin (100 mg/kg, orally gavage every day). The tolerance of glucose and insulin were measured on gestation day 10. Body weight at birth and litter size of offspring were investigated, and the expression of oxidative stress factors [thiobarbituric acid reactive substance (TBARS), glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT)] and AMP-activated protein kinase (AMPK), phospho-AMPK, histone deacetylases 4 (HDAC4), pHDAC4 and glucose-6-phosphatase (G6Pase) in the livers were analyzed by ELISA and Western blot on gestation day 20. Results: High dose curcumin could partly ameliorate the intolerance of glucose and insulin, and completely restore the litter size and the body weight of GD mice through decreased TBARS expression (p < 0.05) and increased GSH, SOD and CAT expression (p < 0.05). Enhanced AMPK activation, accompanied with decreased HDAC4 and G6Pase expression (p < 0.05) were partly contributed to the alleviation of GD mediated by curcumin. Conclusions: Although further detailed mechanism needs to be deciphered, curcumin can be considered as an alternative treatment for gestational diabetes.
format	article
author	Xuehong Lu Fei Wu Mengxue Jiang Xiujuan Sun Geng Tian
author_facet	Xuehong Lu Fei Wu Mengxue Jiang Xiujuan Sun Geng Tian
author_sort	Xuehong Lu
title	Curcumin ameliorates gestational diabetes in mice partly through activating AMPK
title_short	Curcumin ameliorates gestational diabetes in mice partly through activating AMPK
title_full	Curcumin ameliorates gestational diabetes in mice partly through activating AMPK
title_fullStr	Curcumin ameliorates gestational diabetes in mice partly through activating AMPK
title_full_unstemmed	Curcumin ameliorates gestational diabetes in mice partly through activating AMPK
title_sort	curcumin ameliorates gestational diabetes in mice partly through activating ampk
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/19a1b375a69a458588d282f1b7ae09ec
work_keys_str_mv	AT xuehonglu curcuminamelioratesgestationaldiabetesinmicepartlythroughactivatingampk AT feiwu curcuminamelioratesgestationaldiabetesinmicepartlythroughactivatingampk AT mengxuejiang curcuminamelioratesgestationaldiabetesinmicepartlythroughactivatingampk AT xiujuansun curcuminamelioratesgestationaldiabetesinmicepartlythroughactivatingampk AT gengtian curcuminamelioratesgestationaldiabetesinmicepartlythroughactivatingampk
_version_	1718425465640714240

Curcumin ameliorates gestational diabetes in mice partly through activating AMPK

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