The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences
Molecular profiling of breast cancer in non-Caucasian populations remains underexplored. Here the authors report a high prevalence of HER2-subtypes and enriched immune score with improved survival and higher rates of TP53 somatic mutations with poorer survival in ER+ tumours in a Malaysian cohort.
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Nature Portfolio
2020
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oai:doaj.org-article:19a345c9f0be4ab783dcad50c106ed152021-12-02T14:16:14ZThe molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences10.1038/s41467-020-20173-52041-1723https://doaj.org/article/19a345c9f0be4ab783dcad50c106ed152020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20173-5https://doaj.org/toc/2041-1723Molecular profiling of breast cancer in non-Caucasian populations remains underexplored. Here the authors report a high prevalence of HER2-subtypes and enriched immune score with improved survival and higher rates of TP53 somatic mutations with poorer survival in ER+ tumours in a Malaysian cohort.Jia-Wern PanMuhammad Mamduh Ahmad ZabidiPei-Sze NgMei-Yee MengSiti Norhidayu HasanBethan SandeyStephen-John SammutCheng-Har YipPathmanathan RajaduraiOscar M. RuedaCarlos CaldasSuet-Feung ChinSoo-Hwang TeoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jia-Wern Pan Muhammad Mamduh Ahmad Zabidi Pei-Sze Ng Mei-Yee Meng Siti Norhidayu Hasan Bethan Sandey Stephen-John Sammut Cheng-Har Yip Pathmanathan Rajadurai Oscar M. Rueda Carlos Caldas Suet-Feung Chin Soo-Hwang Teo The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences |
| description |
Molecular profiling of breast cancer in non-Caucasian populations remains underexplored. Here the authors report a high prevalence of HER2-subtypes and enriched immune score with improved survival and higher rates of TP53 somatic mutations with poorer survival in ER+ tumours in a Malaysian cohort. |
| format |
article |
| author |
Jia-Wern Pan Muhammad Mamduh Ahmad Zabidi Pei-Sze Ng Mei-Yee Meng Siti Norhidayu Hasan Bethan Sandey Stephen-John Sammut Cheng-Har Yip Pathmanathan Rajadurai Oscar M. Rueda Carlos Caldas Suet-Feung Chin Soo-Hwang Teo |
| author_facet |
Jia-Wern Pan Muhammad Mamduh Ahmad Zabidi Pei-Sze Ng Mei-Yee Meng Siti Norhidayu Hasan Bethan Sandey Stephen-John Sammut Cheng-Har Yip Pathmanathan Rajadurai Oscar M. Rueda Carlos Caldas Suet-Feung Chin Soo-Hwang Teo |
| author_sort |
Jia-Wern Pan |
| title |
The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences |
| title_short |
The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences |
| title_full |
The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences |
| title_fullStr |
The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences |
| title_full_unstemmed |
The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences |
| title_sort |
molecular landscape of asian breast cancers reveals clinically relevant population-specific differences |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/19a345c9f0be4ab783dcad50c106ed15 |
| work_keys_str_mv |
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1718391711224299520 |