A comparison of brain gene expression levels in domesticated and wild animals.

Domestication has led to similar changes in morphology and behavior in several animal species, raising the question whether similarities between different domestication events also exist at the molecular level. We used mRNA sequencing to analyze genome-wide gene expression patterns in brain frontal...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Frank W Albert, Mehmet Somel, Miguel Carneiro, Ayinuer Aximu-Petri, Michel Halbwax, Olaf Thalmann, Jose A Blanco-Aguiar, Irina Z Plyusnina, Lyudmila Trut, Rafael Villafuerte, Nuno Ferrand, Sylvia Kaiser, Per Jensen, Svante Pääbo
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Acceso en línea:https://doaj.org/article/19a76ccef2744b19b7e81d1619aed8c5
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:19a76ccef2744b19b7e81d1619aed8c5
record_format dspace
spelling oai:doaj.org-article:19a76ccef2744b19b7e81d1619aed8c52021-11-18T06:18:04ZA comparison of brain gene expression levels in domesticated and wild animals.1553-73901553-740410.1371/journal.pgen.1002962https://doaj.org/article/19a76ccef2744b19b7e81d1619aed8c52012-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23028369/?tool=EBIhttps://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404Domestication has led to similar changes in morphology and behavior in several animal species, raising the question whether similarities between different domestication events also exist at the molecular level. We used mRNA sequencing to analyze genome-wide gene expression patterns in brain frontal cortex in three pairs of domesticated and wild species (dogs and wolves, pigs and wild boars, and domesticated and wild rabbits). We compared the expression differences with those between domesticated guinea pigs and a distant wild relative (Cavia aperea) as well as between two lines of rats selected for tameness or aggression towards humans. There were few gene expression differences between domesticated and wild dogs, pigs, and rabbits (30-75 genes (less than 1%) of expressed genes were differentially expressed), while guinea pigs and C. aperea differed more strongly. Almost no overlap was found between the genes with differential expression in the different domestication events. In addition, joint analyses of all domesticated and wild samples provided only suggestive evidence for the existence of a small group of genes that changed their expression in a similar fashion in different domesticated species. The most extreme of these shared expression changes include up-regulation in domesticates of SOX6 and PROM1, two modulators of brain development. There was almost no overlap between gene expression in domesticated animals and the tame and aggressive rats. However, two of the genes with the strongest expression differences between the rats (DLL3 and DHDH) were located in a genomic region associated with tameness and aggression, suggesting a role in influencing tameness. In summary, the majority of brain gene expression changes in domesticated animals are specific to the given domestication event, suggesting that the causative variants of behavioral domestication traits may likewise be different.Frank W AlbertMehmet SomelMiguel CarneiroAyinuer Aximu-PetriMichel HalbwaxOlaf ThalmannJose A Blanco-AguiarIrina Z PlyusninaLyudmila TrutRafael VillafuerteNuno FerrandSylvia KaiserPer JensenSvante PääboPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 8, Iss 9, p e1002962 (2012)
institution DOAJ
collection DOAJ
language EN
topic Genetics
QH426-470
spellingShingle Genetics
QH426-470
Frank W Albert
Mehmet Somel
Miguel Carneiro
Ayinuer Aximu-Petri
Michel Halbwax
Olaf Thalmann
Jose A Blanco-Aguiar
Irina Z Plyusnina
Lyudmila Trut
Rafael Villafuerte
Nuno Ferrand
Sylvia Kaiser
Per Jensen
Svante Pääbo
A comparison of brain gene expression levels in domesticated and wild animals.
description Domestication has led to similar changes in morphology and behavior in several animal species, raising the question whether similarities between different domestication events also exist at the molecular level. We used mRNA sequencing to analyze genome-wide gene expression patterns in brain frontal cortex in three pairs of domesticated and wild species (dogs and wolves, pigs and wild boars, and domesticated and wild rabbits). We compared the expression differences with those between domesticated guinea pigs and a distant wild relative (Cavia aperea) as well as between two lines of rats selected for tameness or aggression towards humans. There were few gene expression differences between domesticated and wild dogs, pigs, and rabbits (30-75 genes (less than 1%) of expressed genes were differentially expressed), while guinea pigs and C. aperea differed more strongly. Almost no overlap was found between the genes with differential expression in the different domestication events. In addition, joint analyses of all domesticated and wild samples provided only suggestive evidence for the existence of a small group of genes that changed their expression in a similar fashion in different domesticated species. The most extreme of these shared expression changes include up-regulation in domesticates of SOX6 and PROM1, two modulators of brain development. There was almost no overlap between gene expression in domesticated animals and the tame and aggressive rats. However, two of the genes with the strongest expression differences between the rats (DLL3 and DHDH) were located in a genomic region associated with tameness and aggression, suggesting a role in influencing tameness. In summary, the majority of brain gene expression changes in domesticated animals are specific to the given domestication event, suggesting that the causative variants of behavioral domestication traits may likewise be different.
format article
author Frank W Albert
Mehmet Somel
Miguel Carneiro
Ayinuer Aximu-Petri
Michel Halbwax
Olaf Thalmann
Jose A Blanco-Aguiar
Irina Z Plyusnina
Lyudmila Trut
Rafael Villafuerte
Nuno Ferrand
Sylvia Kaiser
Per Jensen
Svante Pääbo
author_facet Frank W Albert
Mehmet Somel
Miguel Carneiro
Ayinuer Aximu-Petri
Michel Halbwax
Olaf Thalmann
Jose A Blanco-Aguiar
Irina Z Plyusnina
Lyudmila Trut
Rafael Villafuerte
Nuno Ferrand
Sylvia Kaiser
Per Jensen
Svante Pääbo
author_sort Frank W Albert
title A comparison of brain gene expression levels in domesticated and wild animals.
title_short A comparison of brain gene expression levels in domesticated and wild animals.
title_full A comparison of brain gene expression levels in domesticated and wild animals.
title_fullStr A comparison of brain gene expression levels in domesticated and wild animals.
title_full_unstemmed A comparison of brain gene expression levels in domesticated and wild animals.
title_sort comparison of brain gene expression levels in domesticated and wild animals.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/19a76ccef2744b19b7e81d1619aed8c5
work_keys_str_mv AT frankwalbert acomparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT mehmetsomel acomparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT miguelcarneiro acomparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT ayinueraximupetri acomparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT michelhalbwax acomparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT olafthalmann acomparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT joseablancoaguiar acomparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT irinazplyusnina acomparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT lyudmilatrut acomparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT rafaelvillafuerte acomparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT nunoferrand acomparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT sylviakaiser acomparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT perjensen acomparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT svantepaabo acomparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT frankwalbert comparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT mehmetsomel comparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT miguelcarneiro comparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT ayinueraximupetri comparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT michelhalbwax comparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT olafthalmann comparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT joseablancoaguiar comparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT irinazplyusnina comparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT lyudmilatrut comparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT rafaelvillafuerte comparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT nunoferrand comparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT sylviakaiser comparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT perjensen comparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
AT svantepaabo comparisonofbraingeneexpressionlevelsindomesticatedandwildanimals
_version_ 1718424462502658048