Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock

Sakomoto et al. identify naphthofluorescein as a mint3 inhibitor that disrupts the Mint3–FIH-1 interaction and attenuates HIF-1 activity. In vivo experiments in mice reveal a reduction in tumor growth with attenuated inflammatory cytokine production and endotoxic shock, presenting an option for targ...

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Autores principales:	Takeharu Sakamoto, Yuya Fukui, Yasumitsu Kondoh, Kaori Honda, Takeshi Shimizu, Toshiro Hara, Tetsuro Hayashi, Yurika Saitoh, Yoshinori Murakami, Jun-ichiro Inoue, Shuichi Kaneko, Hiroyuki Osada, Motoharu Seiki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/19aa786f0153417ab843292a86a3abc2
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spelling	oai:doaj.org-article:19aa786f0153417ab843292a86a3abc22021-12-02T19:16:17ZPharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock10.1038/s42003-021-02701-12399-3642https://doaj.org/article/19aa786f0153417ab843292a86a3abc22021-10-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02701-1https://doaj.org/toc/2399-3642Sakomoto et al. identify naphthofluorescein as a mint3 inhibitor that disrupts the Mint3–FIH-1 interaction and attenuates HIF-1 activity. In vivo experiments in mice reveal a reduction in tumor growth with attenuated inflammatory cytokine production and endotoxic shock, presenting an option for targeted therapies for cancer and inflammatory diseases that avoid severe adverse effects.Takeharu SakamotoYuya FukuiYasumitsu KondohKaori HondaTakeshi ShimizuToshiro HaraTetsuro HayashiYurika SaitohYoshinori MurakamiJun-ichiro InoueShuichi KanekoHiroyuki OsadaMotoharu SeikiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Takeharu Sakamoto Yuya Fukui Yasumitsu Kondoh Kaori Honda Takeshi Shimizu Toshiro Hara Tetsuro Hayashi Yurika Saitoh Yoshinori Murakami Jun-ichiro Inoue Shuichi Kaneko Hiroyuki Osada Motoharu Seiki Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
description	Sakomoto et al. identify naphthofluorescein as a mint3 inhibitor that disrupts the Mint3–FIH-1 interaction and attenuates HIF-1 activity. In vivo experiments in mice reveal a reduction in tumor growth with attenuated inflammatory cytokine production and endotoxic shock, presenting an option for targeted therapies for cancer and inflammatory diseases that avoid severe adverse effects.
format	article
author	Takeharu Sakamoto Yuya Fukui Yasumitsu Kondoh Kaori Honda Takeshi Shimizu Toshiro Hara Tetsuro Hayashi Yurika Saitoh Yoshinori Murakami Jun-ichiro Inoue Shuichi Kaneko Hiroyuki Osada Motoharu Seiki
author_facet	Takeharu Sakamoto Yuya Fukui Yasumitsu Kondoh Kaori Honda Takeshi Shimizu Toshiro Hara Tetsuro Hayashi Yurika Saitoh Yoshinori Murakami Jun-ichiro Inoue Shuichi Kaneko Hiroyuki Osada Motoharu Seiki
author_sort	Takeharu Sakamoto
title	Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
title_short	Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
title_full	Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
title_fullStr	Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
title_full_unstemmed	Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
title_sort	pharmacological inhibition of mint3 attenuates tumour growth, metastasis, and endotoxic shock
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/19aa786f0153417ab843292a86a3abc2
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Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock

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