Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock

Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock

Sakomoto et al. identify naphthofluorescein as a mint3 inhibitor that disrupts the Mint3–FIH-1 interaction and attenuates HIF-1 activity. In vivo experiments in mice reveal a reduction in tumor growth with attenuated inflammatory cytokine production and endotoxic shock, presenting an option for targ...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Takeharu Sakamoto, Yuya Fukui, Yasumitsu Kondoh, Kaori Honda, Takeshi Shimizu, Toshiro Hara, Tetsuro Hayashi, Yurika Saitoh, Yoshinori Murakami, Jun-ichiro Inoue, Shuichi Kaneko, Hiroyuki Osada, Motoharu Seiki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/19aa786f0153417ab843292a86a3abc2
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares