Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure

Circadian variation of blood pressure, with higher values in the active period, is associated with the risk of fatal cardiovascular events. Here, we show the importance of renal TRPM6, a Magnesium-permeable cation channel, in raising blood pressure by stimulating renin secretion.

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Auteurs principaux:	Yosuke Funato, Daisuke Yamazaki, Daisuke Okuzaki, Nobuhiko Yamamoto, Hiroaki Miki
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/19ab4e3777194204aa8e0dcab04a04d6
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spelling	oai:doaj.org-article:19ab4e3777194204aa8e0dcab04a04d62021-12-02T16:04:12ZImportance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure10.1038/s41467-021-24063-22041-1723https://doaj.org/article/19ab4e3777194204aa8e0dcab04a04d62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24063-2https://doaj.org/toc/2041-1723Circadian variation of blood pressure, with higher values in the active period, is associated with the risk of fatal cardiovascular events. Here, we show the importance of renal TRPM6, a Magnesium-permeable cation channel, in raising blood pressure by stimulating renin secretion.Yosuke FunatoDaisuke YamazakiDaisuke OkuzakiNobuhiko YamamotoHiroaki MikiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yosuke Funato Daisuke Yamazaki Daisuke Okuzaki Nobuhiko Yamamoto Hiroaki Miki Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure
description	Circadian variation of blood pressure, with higher values in the active period, is associated with the risk of fatal cardiovascular events. Here, we show the importance of renal TRPM6, a Magnesium-permeable cation channel, in raising blood pressure by stimulating renin secretion.
format	article
author	Yosuke Funato Daisuke Yamazaki Daisuke Okuzaki Nobuhiko Yamamoto Hiroaki Miki
author_facet	Yosuke Funato Daisuke Yamazaki Daisuke Okuzaki Nobuhiko Yamamoto Hiroaki Miki
author_sort	Yosuke Funato
title	Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure
title_short	Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure
title_full	Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure
title_fullStr	Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure
title_full_unstemmed	Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure
title_sort	importance of the renal ion channel trpm6 in the circadian secretion of renin to raise blood pressure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/19ab4e3777194204aa8e0dcab04a04d6
work_keys_str_mv	AT yosukefunato importanceoftherenalionchanneltrpm6inthecircadiansecretionofrenintoraisebloodpressure AT daisukeyamazaki importanceoftherenalionchanneltrpm6inthecircadiansecretionofrenintoraisebloodpressure AT daisukeokuzaki importanceoftherenalionchanneltrpm6inthecircadiansecretionofrenintoraisebloodpressure AT nobuhikoyamamoto importanceoftherenalionchanneltrpm6inthecircadiansecretionofrenintoraisebloodpressure AT hiroakimiki importanceoftherenalionchanneltrpm6inthecircadiansecretionofrenintoraisebloodpressure
_version_	1718385256552202240

Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure

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