Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure
Circadian variation of blood pressure, with higher values in the active period, is associated with the risk of fatal cardiovascular events. Here, we show the importance of renal TRPM6, a Magnesium-permeable cation channel, in raising blood pressure by stimulating renin secretion.
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2021
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oai:doaj.org-article:19ab4e3777194204aa8e0dcab04a04d62021-12-02T16:04:12ZImportance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure10.1038/s41467-021-24063-22041-1723https://doaj.org/article/19ab4e3777194204aa8e0dcab04a04d62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24063-2https://doaj.org/toc/2041-1723Circadian variation of blood pressure, with higher values in the active period, is associated with the risk of fatal cardiovascular events. Here, we show the importance of renal TRPM6, a Magnesium-permeable cation channel, in raising blood pressure by stimulating renin secretion.Yosuke FunatoDaisuke YamazakiDaisuke OkuzakiNobuhiko YamamotoHiroaki MikiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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Science Q Yosuke Funato Daisuke Yamazaki Daisuke Okuzaki Nobuhiko Yamamoto Hiroaki Miki Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure |
description |
Circadian variation of blood pressure, with higher values in the active period, is associated with the risk of fatal cardiovascular events. Here, we show the importance of renal TRPM6, a Magnesium-permeable cation channel, in raising blood pressure by stimulating renin secretion. |
format |
article |
author |
Yosuke Funato Daisuke Yamazaki Daisuke Okuzaki Nobuhiko Yamamoto Hiroaki Miki |
author_facet |
Yosuke Funato Daisuke Yamazaki Daisuke Okuzaki Nobuhiko Yamamoto Hiroaki Miki |
author_sort |
Yosuke Funato |
title |
Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure |
title_short |
Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure |
title_full |
Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure |
title_fullStr |
Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure |
title_full_unstemmed |
Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure |
title_sort |
importance of the renal ion channel trpm6 in the circadian secretion of renin to raise blood pressure |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/19ab4e3777194204aa8e0dcab04a04d6 |
work_keys_str_mv |
AT yosukefunato importanceoftherenalionchanneltrpm6inthecircadiansecretionofrenintoraisebloodpressure AT daisukeyamazaki importanceoftherenalionchanneltrpm6inthecircadiansecretionofrenintoraisebloodpressure AT daisukeokuzaki importanceoftherenalionchanneltrpm6inthecircadiansecretionofrenintoraisebloodpressure AT nobuhikoyamamoto importanceoftherenalionchanneltrpm6inthecircadiansecretionofrenintoraisebloodpressure AT hiroakimiki importanceoftherenalionchanneltrpm6inthecircadiansecretionofrenintoraisebloodpressure |
_version_ |
1718385256552202240 |