NFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOIIα-mediated decatenation checkpoint.
Although it has been established that nuclear factor with BRCT domain 1/ mediator of the DNA damage checkpoint protein 1 (NFBD1/MDC1) is closely involved in DNA damage response, its possible contribution to the regulation of cell- cycle progression is unclear. In the present study, we have found for...
Guardado en:
Autores principales: | Kiyohiro Ando, Toshinori Ozaki, Toru Hirota, Akira Nakagawara |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2013
|
Materias: | |
Acceso en línea: | https://doaj.org/article/19ab7e8f5bbf4736806f33af988247bd |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation
por: Luying Jia, et al.
Publicado: (2016) -
Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1
por: Åsa Ehlén, et al.
Publicado: (2020) -
Plk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis
por: Masanori Ikeda, et al.
Publicado: (2017) -
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.
por: Marcel A T M van Vugt, et al.
Publicado: (2010) -
Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase
por: Koutarou Nishimura, et al.
Publicado: (2019)