Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies

Abstract This study assessed the possibility of semi-automatic harmonization of standardized uptake values (SUVs) in multicenter studies. Phantom data were acquired using 16 PET/CT scanners (including 3 PET/CT scanners with a silicon photomultiplier detector). PET images obtained using 30-min/bed sc...

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Autores principales:	Hiromitsu Daisaki, Kazuhiro Kitajima, Masatoyo Nakajo, Tadashi Watabe, Kimiteru Ito, Fumi Sakamoto, Tadaki Nakahara, Mana Ishibashi, Akira Toriihara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/19b1de834b034dc791e419a48eca77e7
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spelling	oai:doaj.org-article:19b1de834b034dc791e419a48eca77e72021-12-02T17:32:58ZUsefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies10.1038/s41598-021-87942-02045-2322https://doaj.org/article/19b1de834b034dc791e419a48eca77e72021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87942-0https://doaj.org/toc/2045-2322Abstract This study assessed the possibility of semi-automatic harmonization of standardized uptake values (SUVs) in multicenter studies. Phantom data were acquired using 16 PET/CT scanners (including 3 PET/CT scanners with a silicon photomultiplier detector). PET images obtained using 30-min/bed scans for optimum harmonization filter calculations and using 90–180-s/bed scans for SUV validation under clinical conditions were obtained. Time of flight and a reconstruction method with point-spread function correction were allowed. The optimal full width at half maximum of the 3D-Gaussian filter that minimizes the root mean square error with the median value of the JSNM harmonization range was calculated semi-automatically. The SUVmax and the SUVpeak of the hot spheres were measured, and the inter-scanner coefficient of variation (COV) was calculated before and after harmonization. The harmonization filter was applied to 11 of the 15 PET/CT scanners in which the SUV calibration accuracy had been verified, but not in the remaining 4 scanners. Under noiseless conditions before harmonization, the inter-scanner COVs of the SUVmax and the SUVpeak were as high as 21.57% and 12.20%, respectively, decreasing to 8.79% and 5.73% after harmonization, respectively. Harmonization brought the SUVmax of all the hot spheres to within the harmonization range. Even under clinical conditions affected by image noise, the inter-scanner COVs for the SUVmax and SUVpeak were as high as 8.83% and 5.18% after harmonization, respectively. By applying an optimal harmonization filter that is calculated semi-automatically, the harmonization of SUVs according to the JSNM strategy is possible in multicenter studies, thereby reducing inter-scanner COVs.Hiromitsu DaisakiKazuhiro KitajimaMasatoyo NakajoTadashi WatabeKimiteru ItoFumi SakamotoTadaki NakaharaMana IshibashiAkira ToriiharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiromitsu Daisaki Kazuhiro Kitajima Masatoyo Nakajo Tadashi Watabe Kimiteru Ito Fumi Sakamoto Tadaki Nakahara Mana Ishibashi Akira Toriihara Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies
description	Abstract This study assessed the possibility of semi-automatic harmonization of standardized uptake values (SUVs) in multicenter studies. Phantom data were acquired using 16 PET/CT scanners (including 3 PET/CT scanners with a silicon photomultiplier detector). PET images obtained using 30-min/bed scans for optimum harmonization filter calculations and using 90–180-s/bed scans for SUV validation under clinical conditions were obtained. Time of flight and a reconstruction method with point-spread function correction were allowed. The optimal full width at half maximum of the 3D-Gaussian filter that minimizes the root mean square error with the median value of the JSNM harmonization range was calculated semi-automatically. The SUVmax and the SUVpeak of the hot spheres were measured, and the inter-scanner coefficient of variation (COV) was calculated before and after harmonization. The harmonization filter was applied to 11 of the 15 PET/CT scanners in which the SUV calibration accuracy had been verified, but not in the remaining 4 scanners. Under noiseless conditions before harmonization, the inter-scanner COVs of the SUVmax and the SUVpeak were as high as 21.57% and 12.20%, respectively, decreasing to 8.79% and 5.73% after harmonization, respectively. Harmonization brought the SUVmax of all the hot spheres to within the harmonization range. Even under clinical conditions affected by image noise, the inter-scanner COVs for the SUVmax and SUVpeak were as high as 8.83% and 5.18% after harmonization, respectively. By applying an optimal harmonization filter that is calculated semi-automatically, the harmonization of SUVs according to the JSNM strategy is possible in multicenter studies, thereby reducing inter-scanner COVs.
format	article
author	Hiromitsu Daisaki Kazuhiro Kitajima Masatoyo Nakajo Tadashi Watabe Kimiteru Ito Fumi Sakamoto Tadaki Nakahara Mana Ishibashi Akira Toriihara
author_facet	Hiromitsu Daisaki Kazuhiro Kitajima Masatoyo Nakajo Tadashi Watabe Kimiteru Ito Fumi Sakamoto Tadaki Nakahara Mana Ishibashi Akira Toriihara
author_sort	Hiromitsu Daisaki
title	Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies
title_short	Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies
title_full	Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies
title_fullStr	Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies
title_full_unstemmed	Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies
title_sort	usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter pet studies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/19b1de834b034dc791e419a48eca77e7
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Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies

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