The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes

Abstract Auto-immune diseases involved at least 25% of the population in wealthy countries. Several factors including genetic, epigenetic, and environmental elements are implicated in development of Rheumatoid Arthritis as an autoimmune disease. Autoantibodies cause synovial inflammation and arthrit...

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Autores principales:	Zahra Payandeh, Abbas Pirpour Tazehkand, Ali Azargoonjahromi, Faezeh Almasi, Armina Alagheband Bahrami
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Rheumatoid arthritis Exosome Autoimmune diseases Therapy Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/19b20a0351bc4b179a4f31d8e2128c2b
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spelling	oai:doaj.org-article:19b20a0351bc4b179a4f31d8e2128c2b2021-11-07T12:06:20ZThe Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes10.1186/s12575-021-00158-41480-9222https://doaj.org/article/19b20a0351bc4b179a4f31d8e2128c2b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12575-021-00158-4https://doaj.org/toc/1480-9222Abstract Auto-immune diseases involved at least 25% of the population in wealthy countries. Several factors including genetic, epigenetic, and environmental elements are implicated in development of Rheumatoid Arthritis as an autoimmune disease. Autoantibodies cause synovial inflammation and arthritis, if left untreated or being under continual external stimulation, could result in chronic inflammation, joint injury, and disability. T- and B-cells, signaling molecules, proinflammatory mediators, and synovium-specific targets are among the new therapeutic targets. Exosomes could be employed as therapeutic vectors in the treatment of autoimmune diseases. Herein, the role of cell organelle particularly exosomes in Rheumatoid Arthritis had discussed and some therapeutic applications of exosome highlighted.Zahra PayandehAbbas Pirpour TazehkandAli AzargoonjahromiFaezeh AlmasiArmina Alagheband BahramiBMCarticleRheumatoid arthritisExosomeAutoimmune diseasesTherapyMedicine (General)R5-920Biology (General)QH301-705.5ENBiological Procedures Online, Vol 23, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Rheumatoid arthritis Exosome Autoimmune diseases Therapy Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	Rheumatoid arthritis Exosome Autoimmune diseases Therapy Medicine (General) R5-920 Biology (General) QH301-705.5 Zahra Payandeh Abbas Pirpour Tazehkand Ali Azargoonjahromi Faezeh Almasi Armina Alagheband Bahrami The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes
description	Abstract Auto-immune diseases involved at least 25% of the population in wealthy countries. Several factors including genetic, epigenetic, and environmental elements are implicated in development of Rheumatoid Arthritis as an autoimmune disease. Autoantibodies cause synovial inflammation and arthritis, if left untreated or being under continual external stimulation, could result in chronic inflammation, joint injury, and disability. T- and B-cells, signaling molecules, proinflammatory mediators, and synovium-specific targets are among the new therapeutic targets. Exosomes could be employed as therapeutic vectors in the treatment of autoimmune diseases. Herein, the role of cell organelle particularly exosomes in Rheumatoid Arthritis had discussed and some therapeutic applications of exosome highlighted.
format	article
author	Zahra Payandeh Abbas Pirpour Tazehkand Ali Azargoonjahromi Faezeh Almasi Armina Alagheband Bahrami
author_facet	Zahra Payandeh Abbas Pirpour Tazehkand Ali Azargoonjahromi Faezeh Almasi Armina Alagheband Bahrami
author_sort	Zahra Payandeh
title	The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes
title_short	The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes
title_full	The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes
title_fullStr	The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes
title_full_unstemmed	The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes
title_sort	role of cell organelles in rheumatoid arthritis with focus on exosomes
publisher	BMC
publishDate	2021
url	https://doaj.org/article/19b20a0351bc4b179a4f31d8e2128c2b
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The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes

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