Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review

Many flavonoids, as eminent phenolic compounds, have been commercialized and consumed as dietary supplements due to their incredible human health benefits. In the present study, a bioactive flavone glycoside linarin (LN) was designated to comprehensively overview its phytochemical and biological pro...

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Autores principales:	Javad Mottaghipisheh, Hadi Taghrir, Anahita Boveiri Dehsheikh, Kamiar Zomorodian, Cambyz Irajie, Mohammad Mahmoodi Sourestani, Aida Iraji
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	flavonoids linarin chemotaxonomy phytochemistry bioactivities Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/19bebc7c15fc489aa578be78ea6fdc47
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spelling	oai:doaj.org-article:19bebc7c15fc489aa578be78ea6fdc472021-11-25T18:39:22ZLinarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review10.3390/ph141111041424-8247https://doaj.org/article/19bebc7c15fc489aa578be78ea6fdc472021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1104https://doaj.org/toc/1424-8247Many flavonoids, as eminent phenolic compounds, have been commercialized and consumed as dietary supplements due to their incredible human health benefits. In the present study, a bioactive flavone glycoside linarin (LN) was designated to comprehensively overview its phytochemical and biological properties. LN has been characterized abundantly in the <i>Cirsium</i>, <i>Micromeria</i>, and <i>Buddleja</i> species belonging to Asteraceae, Lamiaceae, and Scrophulariaceae families, respectively. Biological assessments exhibited promising activities of LN, particularly, the remedial effects on central nervous system (CNS) disorders, whereas the remarkable sleep enhancing and sedative effects as well as AChE (acetylcholinesterase) inhibitory activity were highlighted. Of note, LN has indicated promising anti osteoblast proliferation and differentiation, thus a bone formation effect. Further biological and pharmacological assessments of LN and its optimized semi-synthetic derivatives, specifically its therapeutic characteristics on osteoarthritis and osteoporosis, might lead to uncovering potential drug candidates.Javad MottaghipishehHadi TaghrirAnahita Boveiri DehsheikhKamiar ZomorodianCambyz IrajieMohammad Mahmoodi SourestaniAida IrajiMDPI AGarticleflavonoidslinarinchemotaxonomyphytochemistrybioactivitiesMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1104, p 1104 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	flavonoids linarin chemotaxonomy phytochemistry bioactivities Medicine R Pharmacy and materia medica RS1-441
spellingShingle	flavonoids linarin chemotaxonomy phytochemistry bioactivities Medicine R Pharmacy and materia medica RS1-441 Javad Mottaghipisheh Hadi Taghrir Anahita Boveiri Dehsheikh Kamiar Zomorodian Cambyz Irajie Mohammad Mahmoodi Sourestani Aida Iraji Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review
description	Many flavonoids, as eminent phenolic compounds, have been commercialized and consumed as dietary supplements due to their incredible human health benefits. In the present study, a bioactive flavone glycoside linarin (LN) was designated to comprehensively overview its phytochemical and biological properties. LN has been characterized abundantly in the <i>Cirsium</i>, <i>Micromeria</i>, and <i>Buddleja</i> species belonging to Asteraceae, Lamiaceae, and Scrophulariaceae families, respectively. Biological assessments exhibited promising activities of LN, particularly, the remedial effects on central nervous system (CNS) disorders, whereas the remarkable sleep enhancing and sedative effects as well as AChE (acetylcholinesterase) inhibitory activity were highlighted. Of note, LN has indicated promising anti osteoblast proliferation and differentiation, thus a bone formation effect. Further biological and pharmacological assessments of LN and its optimized semi-synthetic derivatives, specifically its therapeutic characteristics on osteoarthritis and osteoporosis, might lead to uncovering potential drug candidates.
format	article
author	Javad Mottaghipisheh Hadi Taghrir Anahita Boveiri Dehsheikh Kamiar Zomorodian Cambyz Irajie Mohammad Mahmoodi Sourestani Aida Iraji
author_facet	Javad Mottaghipisheh Hadi Taghrir Anahita Boveiri Dehsheikh Kamiar Zomorodian Cambyz Irajie Mohammad Mahmoodi Sourestani Aida Iraji
author_sort	Javad Mottaghipisheh
title	Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review
title_short	Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review
title_full	Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review
title_fullStr	Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review
title_full_unstemmed	Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review
title_sort	linarin, a glycosylated flavonoid, with potential therapeutic attributes: a comprehensive review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/19bebc7c15fc489aa578be78ea6fdc47
work_keys_str_mv	AT javadmottaghipisheh linarinaglycosylatedflavonoidwithpotentialtherapeuticattributesacomprehensivereview AT haditaghrir linarinaglycosylatedflavonoidwithpotentialtherapeuticattributesacomprehensivereview AT anahitaboveiridehsheikh linarinaglycosylatedflavonoidwithpotentialtherapeuticattributesacomprehensivereview AT kamiarzomorodian linarinaglycosylatedflavonoidwithpotentialtherapeuticattributesacomprehensivereview AT cambyzirajie linarinaglycosylatedflavonoidwithpotentialtherapeuticattributesacomprehensivereview AT mohammadmahmoodisourestani linarinaglycosylatedflavonoidwithpotentialtherapeuticattributesacomprehensivereview AT aidairaji linarinaglycosylatedflavonoidwithpotentialtherapeuticattributesacomprehensivereview
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Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review

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