Residential exposure to electromagnetic fields and risk of amyotrophic lateral sclerosis: a dose–response meta-analysis

Abstract Amyotrophic lateral sclerosis (ALS) is neurodegenerative disease characterized by a fatal prognosis and still unknown etiology. Some environmental risk factors have been suggested, including exposure to magnetic fields. Studies have suggested positive associations in occupationally-exposed...

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Autores principales:	Tommaso Filippini, Elizabeth E. Hatch, Marco Vinceti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/19c0d95eec94468cafe85b04b818db69
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spelling	oai:doaj.org-article:19c0d95eec94468cafe85b04b818db692021-12-02T17:47:36ZResidential exposure to electromagnetic fields and risk of amyotrophic lateral sclerosis: a dose–response meta-analysis10.1038/s41598-021-91349-22045-2322https://doaj.org/article/19c0d95eec94468cafe85b04b818db692021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91349-2https://doaj.org/toc/2045-2322Abstract Amyotrophic lateral sclerosis (ALS) is neurodegenerative disease characterized by a fatal prognosis and still unknown etiology. Some environmental risk factors have been suggested, including exposure to magnetic fields. Studies have suggested positive associations in occupationally-exposed populations, but the link with residential exposure is still debated as is the shape of such relation. Due to recent availability of advanced biostatistical tools for dose–response meta-analysis, we carried out a systematic review in order to assess the dose–response association between ALS and residential exposure to magnetic fields. We performed an online literature searching through April 30, 2021. Studies were included if they assessed residential exposure to electromagnetic fields, based either on distance from overhead power lines or on magnetic field modelling techniques, and if they reported risk estimates for ALS. We identified six eligible studies, four using distance-based and one modelling-based exposure assessment, and one both methods. Both distance-based and particularly modelling-based exposure estimates appeared to be associated with a decreased ALS risk in the highest exposure category, although estimates were very imprecise (summary RRs 0.87, 95% CI 0.63–1.20, and 0.27, 95% CI 0.05–1.36). Dose–response meta-analysis also showed little association between distance from power lines and ALS, with no evidence of any threshold. Overall, we found scant evidence of a positive association between residential magnetic fields exposure and ALS, although the available data were too limited to conduct a dose–response analysis for the modelled magnetic field estimates or to perform stratified analyses.Tommaso FilippiniElizabeth E. HatchMarco VincetiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tommaso Filippini Elizabeth E. Hatch Marco Vinceti Residential exposure to electromagnetic fields and risk of amyotrophic lateral sclerosis: a dose–response meta-analysis
description	Abstract Amyotrophic lateral sclerosis (ALS) is neurodegenerative disease characterized by a fatal prognosis and still unknown etiology. Some environmental risk factors have been suggested, including exposure to magnetic fields. Studies have suggested positive associations in occupationally-exposed populations, but the link with residential exposure is still debated as is the shape of such relation. Due to recent availability of advanced biostatistical tools for dose–response meta-analysis, we carried out a systematic review in order to assess the dose–response association between ALS and residential exposure to magnetic fields. We performed an online literature searching through April 30, 2021. Studies were included if they assessed residential exposure to electromagnetic fields, based either on distance from overhead power lines or on magnetic field modelling techniques, and if they reported risk estimates for ALS. We identified six eligible studies, four using distance-based and one modelling-based exposure assessment, and one both methods. Both distance-based and particularly modelling-based exposure estimates appeared to be associated with a decreased ALS risk in the highest exposure category, although estimates were very imprecise (summary RRs 0.87, 95% CI 0.63–1.20, and 0.27, 95% CI 0.05–1.36). Dose–response meta-analysis also showed little association between distance from power lines and ALS, with no evidence of any threshold. Overall, we found scant evidence of a positive association between residential magnetic fields exposure and ALS, although the available data were too limited to conduct a dose–response analysis for the modelled magnetic field estimates or to perform stratified analyses.
format	article
author	Tommaso Filippini Elizabeth E. Hatch Marco Vinceti
author_facet	Tommaso Filippini Elizabeth E. Hatch Marco Vinceti
author_sort	Tommaso Filippini
title	Residential exposure to electromagnetic fields and risk of amyotrophic lateral sclerosis: a dose–response meta-analysis
title_short	Residential exposure to electromagnetic fields and risk of amyotrophic lateral sclerosis: a dose–response meta-analysis
title_full	Residential exposure to electromagnetic fields and risk of amyotrophic lateral sclerosis: a dose–response meta-analysis
title_fullStr	Residential exposure to electromagnetic fields and risk of amyotrophic lateral sclerosis: a dose–response meta-analysis
title_full_unstemmed	Residential exposure to electromagnetic fields and risk of amyotrophic lateral sclerosis: a dose–response meta-analysis
title_sort	residential exposure to electromagnetic fields and risk of amyotrophic lateral sclerosis: a dose–response meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/19c0d95eec94468cafe85b04b818db69
work_keys_str_mv	AT tommasofilippini residentialexposuretoelectromagneticfieldsandriskofamyotrophiclateralsclerosisadoseresponsemetaanalysis AT elizabethehatch residentialexposuretoelectromagneticfieldsandriskofamyotrophiclateralsclerosisadoseresponsemetaanalysis AT marcovinceti residentialexposuretoelectromagneticfieldsandriskofamyotrophiclateralsclerosisadoseresponsemetaanalysis
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Residential exposure to electromagnetic fields and risk of amyotrophic lateral sclerosis: a dose–response meta-analysis

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