Effects of huoxin formula on the arterial functions of patients with coronary heart disease

Context: Huoxin formula is a Traditional Chinese Medicine for coronary heart disease (CHD) treatment. Objective: To explore the therapeutic mechanism of the Huoxin formula on arterial functions in CHD patients. Materials and methods: Fifty-eight CHD patients receiving cardiovascular drugs including...

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Autores principales:	Yan Xu, Hongyi Hu, Yi Li, Rong Cen, Chengzeng Yao, Wenhuan Ma, Minhua Huang, Yahui Yin, Hongzhi Gao, Yongming Liu, Alexander Endler
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	hscrp inflammatory factor cavi abi imt Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/19c61ed9bc8b4b0b8fcef6c5421f5719
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spelling	oai:doaj.org-article:19c61ed9bc8b4b0b8fcef6c5421f57192021-11-17T14:21:55ZEffects of huoxin formula on the arterial functions of patients with coronary heart disease1388-02091744-511610.1080/13880209.2018.1561726https://doaj.org/article/19c61ed9bc8b4b0b8fcef6c5421f57192019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2018.1561726https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Huoxin formula is a Traditional Chinese Medicine for coronary heart disease (CHD) treatment. Objective: To explore the therapeutic mechanism of the Huoxin formula on arterial functions in CHD patients. Materials and methods: Fifty-eight CHD patients receiving cardiovascular drugs including β-receptor blocker, statins, and antiplatelet medications or others were randomized into intervention [additionally 13.5 g Huoxin formula granules dissolved in 150 mL warm water per time, twice a day (n = 30)] and control [only cardiovascular drugs (n = 28)] groups. Serum biomarkers (hs-CRP, IL-18, IL-17, TNF-α, MMP-9), and cardiovascular indicators of the common and internal carotid arteries (ICAs) were monitored before and after the treatments. Results: After 3 months of treatment, the increases of intima-media thicknesses (IMT) of the left and right common carotid arteries (CCAs) as well as of the left and right ICAs and the increases of the left and right cardio-ankle vascular index were all significantly (all p < 0.001) less in the intervention than in control group (all p < 0.001). Serum concentrations reductions of hs-CRP, IL-18, IL-17 and MMP9 (all p < 0.001) levels were higher in the intervention compared to the control group, which correlated with the changes of left ICA (hs-CRP: r = 0.581, p = 0.009; IL-18: r = 0.594, p = 0.007; IL-17: r = 0.575, p = 0.006). Discussion and conclusion: Since the Huoxin formula improved arterial functions and reduced inflammatory factor activities in CHD patients, a large-scale clinical trial is warranted.Yan XuHongyi HuYi LiRong CenChengzeng YaoWenhuan MaMinhua HuangYahui YinHongzhi GaoYongming LiuAlexander EndlerTaylor & Francis Grouparticlehscrpinflammatory factorcaviabiimtTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 13-20 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	hscrp inflammatory factor cavi abi imt Therapeutics. Pharmacology RM1-950
spellingShingle	hscrp inflammatory factor cavi abi imt Therapeutics. Pharmacology RM1-950 Yan Xu Hongyi Hu Yi Li Rong Cen Chengzeng Yao Wenhuan Ma Minhua Huang Yahui Yin Hongzhi Gao Yongming Liu Alexander Endler Effects of huoxin formula on the arterial functions of patients with coronary heart disease
description	Context: Huoxin formula is a Traditional Chinese Medicine for coronary heart disease (CHD) treatment. Objective: To explore the therapeutic mechanism of the Huoxin formula on arterial functions in CHD patients. Materials and methods: Fifty-eight CHD patients receiving cardiovascular drugs including β-receptor blocker, statins, and antiplatelet medications or others were randomized into intervention [additionally 13.5 g Huoxin formula granules dissolved in 150 mL warm water per time, twice a day (n = 30)] and control [only cardiovascular drugs (n = 28)] groups. Serum biomarkers (hs-CRP, IL-18, IL-17, TNF-α, MMP-9), and cardiovascular indicators of the common and internal carotid arteries (ICAs) were monitored before and after the treatments. Results: After 3 months of treatment, the increases of intima-media thicknesses (IMT) of the left and right common carotid arteries (CCAs) as well as of the left and right ICAs and the increases of the left and right cardio-ankle vascular index were all significantly (all p < 0.001) less in the intervention than in control group (all p < 0.001). Serum concentrations reductions of hs-CRP, IL-18, IL-17 and MMP9 (all p < 0.001) levels were higher in the intervention compared to the control group, which correlated with the changes of left ICA (hs-CRP: r = 0.581, p = 0.009; IL-18: r = 0.594, p = 0.007; IL-17: r = 0.575, p = 0.006). Discussion and conclusion: Since the Huoxin formula improved arterial functions and reduced inflammatory factor activities in CHD patients, a large-scale clinical trial is warranted.
format	article
author	Yan Xu Hongyi Hu Yi Li Rong Cen Chengzeng Yao Wenhuan Ma Minhua Huang Yahui Yin Hongzhi Gao Yongming Liu Alexander Endler
author_facet	Yan Xu Hongyi Hu Yi Li Rong Cen Chengzeng Yao Wenhuan Ma Minhua Huang Yahui Yin Hongzhi Gao Yongming Liu Alexander Endler
author_sort	Yan Xu
title	Effects of huoxin formula on the arterial functions of patients with coronary heart disease
title_short	Effects of huoxin formula on the arterial functions of patients with coronary heart disease
title_full	Effects of huoxin formula on the arterial functions of patients with coronary heart disease
title_fullStr	Effects of huoxin formula on the arterial functions of patients with coronary heart disease
title_full_unstemmed	Effects of huoxin formula on the arterial functions of patients with coronary heart disease
title_sort	effects of huoxin formula on the arterial functions of patients with coronary heart disease
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/19c61ed9bc8b4b0b8fcef6c5421f5719
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_version_	1718425465837846528

Effects of huoxin formula on the arterial functions of patients with coronary heart disease

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