Effects of huoxin formula on the arterial functions of patients with coronary heart disease
Context: Huoxin formula is a Traditional Chinese Medicine for coronary heart disease (CHD) treatment. Objective: To explore the therapeutic mechanism of the Huoxin formula on arterial functions in CHD patients. Materials and methods: Fifty-eight CHD patients receiving cardiovascular drugs including...
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Taylor & Francis Group
2019
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oai:doaj.org-article:19c61ed9bc8b4b0b8fcef6c5421f57192021-11-17T14:21:55ZEffects of huoxin formula on the arterial functions of patients with coronary heart disease1388-02091744-511610.1080/13880209.2018.1561726https://doaj.org/article/19c61ed9bc8b4b0b8fcef6c5421f57192019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2018.1561726https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Huoxin formula is a Traditional Chinese Medicine for coronary heart disease (CHD) treatment. Objective: To explore the therapeutic mechanism of the Huoxin formula on arterial functions in CHD patients. Materials and methods: Fifty-eight CHD patients receiving cardiovascular drugs including β-receptor blocker, statins, and antiplatelet medications or others were randomized into intervention [additionally 13.5 g Huoxin formula granules dissolved in 150 mL warm water per time, twice a day (n = 30)] and control [only cardiovascular drugs (n = 28)] groups. Serum biomarkers (hs-CRP, IL-18, IL-17, TNF-α, MMP-9), and cardiovascular indicators of the common and internal carotid arteries (ICAs) were monitored before and after the treatments. Results: After 3 months of treatment, the increases of intima-media thicknesses (IMT) of the left and right common carotid arteries (CCAs) as well as of the left and right ICAs and the increases of the left and right cardio-ankle vascular index were all significantly (all p < 0.001) less in the intervention than in control group (all p < 0.001). Serum concentrations reductions of hs-CRP, IL-18, IL-17 and MMP9 (all p < 0.001) levels were higher in the intervention compared to the control group, which correlated with the changes of left ICA (hs-CRP: r = 0.581, p = 0.009; IL-18: r = 0.594, p = 0.007; IL-17: r = 0.575, p = 0.006). Discussion and conclusion: Since the Huoxin formula improved arterial functions and reduced inflammatory factor activities in CHD patients, a large-scale clinical trial is warranted.Yan XuHongyi HuYi LiRong CenChengzeng YaoWenhuan MaMinhua HuangYahui YinHongzhi GaoYongming LiuAlexander EndlerTaylor & Francis Grouparticlehscrpinflammatory factorcaviabiimtTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 13-20 (2019) |
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hscrp inflammatory factor cavi abi imt Therapeutics. Pharmacology RM1-950 |
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hscrp inflammatory factor cavi abi imt Therapeutics. Pharmacology RM1-950 Yan Xu Hongyi Hu Yi Li Rong Cen Chengzeng Yao Wenhuan Ma Minhua Huang Yahui Yin Hongzhi Gao Yongming Liu Alexander Endler Effects of huoxin formula on the arterial functions of patients with coronary heart disease |
| description |
Context: Huoxin formula is a Traditional Chinese Medicine for coronary heart disease (CHD) treatment. Objective: To explore the therapeutic mechanism of the Huoxin formula on arterial functions in CHD patients. Materials and methods: Fifty-eight CHD patients receiving cardiovascular drugs including β-receptor blocker, statins, and antiplatelet medications or others were randomized into intervention [additionally 13.5 g Huoxin formula granules dissolved in 150 mL warm water per time, twice a day (n = 30)] and control [only cardiovascular drugs (n = 28)] groups. Serum biomarkers (hs-CRP, IL-18, IL-17, TNF-α, MMP-9), and cardiovascular indicators of the common and internal carotid arteries (ICAs) were monitored before and after the treatments. Results: After 3 months of treatment, the increases of intima-media thicknesses (IMT) of the left and right common carotid arteries (CCAs) as well as of the left and right ICAs and the increases of the left and right cardio-ankle vascular index were all significantly (all p < 0.001) less in the intervention than in control group (all p < 0.001). Serum concentrations reductions of hs-CRP, IL-18, IL-17 and MMP9 (all p < 0.001) levels were higher in the intervention compared to the control group, which correlated with the changes of left ICA (hs-CRP: r = 0.581, p = 0.009; IL-18: r = 0.594, p = 0.007; IL-17: r = 0.575, p = 0.006). Discussion and conclusion: Since the Huoxin formula improved arterial functions and reduced inflammatory factor activities in CHD patients, a large-scale clinical trial is warranted. |
| format |
article |
| author |
Yan Xu Hongyi Hu Yi Li Rong Cen Chengzeng Yao Wenhuan Ma Minhua Huang Yahui Yin Hongzhi Gao Yongming Liu Alexander Endler |
| author_facet |
Yan Xu Hongyi Hu Yi Li Rong Cen Chengzeng Yao Wenhuan Ma Minhua Huang Yahui Yin Hongzhi Gao Yongming Liu Alexander Endler |
| author_sort |
Yan Xu |
| title |
Effects of huoxin formula on the arterial functions of patients with coronary heart disease |
| title_short |
Effects of huoxin formula on the arterial functions of patients with coronary heart disease |
| title_full |
Effects of huoxin formula on the arterial functions of patients with coronary heart disease |
| title_fullStr |
Effects of huoxin formula on the arterial functions of patients with coronary heart disease |
| title_full_unstemmed |
Effects of huoxin formula on the arterial functions of patients with coronary heart disease |
| title_sort |
effects of huoxin formula on the arterial functions of patients with coronary heart disease |
| publisher |
Taylor & Francis Group |
| publishDate |
2019 |
| url |
https://doaj.org/article/19c61ed9bc8b4b0b8fcef6c5421f5719 |
| work_keys_str_mv |
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