Alternative activation generates IL-10 producing type 2 innate lymphoid cells

Alternative activation generates IL-10 producing type 2 innate lymphoid cells

Type 2 innate lymphoid cells (ILC2) are thought to be a uniform population of effector cells that produce IL-5 and IL-13. Here, the authors shown that, in mice, IL-33 can alternatively activate these cells to generate a molecularly distinct IL-10-producing subset designated ILC210.

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Bibliographic Details
Main Authors: Corey R. Seehus, Asha Kadavallore, Brian de la Torre, Alyson R. Yeckes, Yizhou Wang, Jie Tang, Jonathan Kaye
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/19c8c7f5c9a0482b93c72c88a8ce8cae
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Summary:Type 2 innate lymphoid cells (ILC2) are thought to be a uniform population of effector cells that produce IL-5 and IL-13. Here, the authors shown that, in mice, IL-33 can alternatively activate these cells to generate a molecularly distinct IL-10-producing subset designated ILC210.

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