Mitophagy in carcinogenesis and cancer treatment

Abstract In order to maintain a functional mitochondrial network, cells have developed a quality control mechanism, namely mitophagy. This process can be induced through different pathways. The most studied is the so-called PINK1/Parkin pathway, which is associated with ubiquitylation of several mit...

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Autores principales:	Tatiana V. Denisenko, Vladimir Gogvadze, Boris Zhivotovsky
Formato:	article
Lenguaje:	EN
Publicado:	Springer 2021
Materias:	Mitophagy Autophagy Cancer Homeostasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/19c9a79233374fc6bd88c22958758d8b
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spelling	oai:doaj.org-article:19c9a79233374fc6bd88c22958758d8b2021-12-05T12:26:28ZMitophagy in carcinogenesis and cancer treatment10.1007/s12672-021-00454-12730-6011https://doaj.org/article/19c9a79233374fc6bd88c22958758d8b2021-12-01T00:00:00Zhttps://doi.org/10.1007/s12672-021-00454-1https://doaj.org/toc/2730-6011Abstract In order to maintain a functional mitochondrial network, cells have developed a quality control mechanism, namely mitophagy. This process can be induced through different pathways. The most studied is the so-called PINK1/Parkin pathway, which is associated with ubiquitylation of several mitochondrial proteins that were initially found to be related to Parkinson’s disease. Another type of mitophagy is known as receptor-mediated mitophagy, which includes proteins, such as BNIP3 and BNIP3L, also known as Nix. Through these two mechanisms, mitophagy fulfills its functions and maintains cellular homeostasis. Here, we summarize the current knowledge about the mechanisms of mitophagy regulation and their interplay with cancer progression as well as anticancer treatment.Tatiana V. DenisenkoVladimir GogvadzeBoris ZhivotovskySpringerarticleMitophagyAutophagyCancerHomeostasisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENDiscover Oncology, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mitophagy Autophagy Cancer Homeostasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Mitophagy Autophagy Cancer Homeostasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Tatiana V. Denisenko Vladimir Gogvadze Boris Zhivotovsky Mitophagy in carcinogenesis and cancer treatment
description	Abstract In order to maintain a functional mitochondrial network, cells have developed a quality control mechanism, namely mitophagy. This process can be induced through different pathways. The most studied is the so-called PINK1/Parkin pathway, which is associated with ubiquitylation of several mitochondrial proteins that were initially found to be related to Parkinson’s disease. Another type of mitophagy is known as receptor-mediated mitophagy, which includes proteins, such as BNIP3 and BNIP3L, also known as Nix. Through these two mechanisms, mitophagy fulfills its functions and maintains cellular homeostasis. Here, we summarize the current knowledge about the mechanisms of mitophagy regulation and their interplay with cancer progression as well as anticancer treatment.
format	article
author	Tatiana V. Denisenko Vladimir Gogvadze Boris Zhivotovsky
author_facet	Tatiana V. Denisenko Vladimir Gogvadze Boris Zhivotovsky
author_sort	Tatiana V. Denisenko
title	Mitophagy in carcinogenesis and cancer treatment
title_short	Mitophagy in carcinogenesis and cancer treatment
title_full	Mitophagy in carcinogenesis and cancer treatment
title_fullStr	Mitophagy in carcinogenesis and cancer treatment
title_full_unstemmed	Mitophagy in carcinogenesis and cancer treatment
title_sort	mitophagy in carcinogenesis and cancer treatment
publisher	Springer
publishDate	2021
url	https://doaj.org/article/19c9a79233374fc6bd88c22958758d8b
work_keys_str_mv	AT tatianavdenisenko mitophagyincarcinogenesisandcancertreatment AT vladimirgogvadze mitophagyincarcinogenesisandcancertreatment AT boriszhivotovsky mitophagyincarcinogenesisandcancertreatment
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Mitophagy in carcinogenesis and cancer treatment

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