Tumor necrosis factor prevents Candida albicans biofilm formation

Abstract Candida species are commensals but some develop biofilms in prosthetic materials and host surfaces that may represent up to 30% of deaths related to infections, particularly in immunosuppressed patients. Tumor necrosis factor (TNF) exhibits a plethora of functions in host defense mechanisms...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Francisco Airton Castro Rocha, Anelise Maria Costa Vasconcelos Alves, Marcos Fábio Gadelha Rocha, Rossana de Aguiar Cordeiro, Raimunda Sâmia Nogueira Brilhante, Ana Carolina Matias Dinelly Pinto, Rodolfo de Melo Nunes, Virgínia Cláudia Carneiro Girão, José Julio Costa Sidrim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/19cc5543f09b4e64b00f345ec25d558c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:19cc5543f09b4e64b00f345ec25d558c
record_format	dspace
spelling	oai:doaj.org-article:19cc5543f09b4e64b00f345ec25d558c2021-12-02T11:40:42ZTumor necrosis factor prevents Candida albicans biofilm formation10.1038/s41598-017-01400-42045-2322https://doaj.org/article/19cc5543f09b4e64b00f345ec25d558c2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01400-4https://doaj.org/toc/2045-2322Abstract Candida species are commensals but some develop biofilms in prosthetic materials and host surfaces that may represent up to 30% of deaths related to infections, particularly in immunosuppressed patients. Tumor necrosis factor (TNF) exhibits a plethora of functions in host defense mechanisms whereas excessive release of TNF in inflammation promotes tissue damage. Cytokines released in an inflammatory milieu may influence the development of microorganisms either by promoting their growth or displaying antimicrobial activity. In protozoa, TNF may affect growth by coupling through a lectin-like domain, distinct from TNF receptors. TNF was also shown to interact with bacteria via a mechanism that does not involve classical TNF receptors. Using an in vitro C. albicans biofilm model, we show that TNF dose-dependently prevents biofilm development that is blocked by incubating TNF with N,N’-diacetylchitobiose, a major carbohydrate component of C. albicans cell wall. This finding represents a relevant and hitherto unknown mechanism that adds to the understanding of why TNF blockade is associated with opportunistic C. albicans infections.Francisco Airton Castro RochaAnelise Maria Costa Vasconcelos AlvesMarcos Fábio Gadelha RochaRossana de Aguiar CordeiroRaimunda Sâmia Nogueira BrilhanteAna Carolina Matias Dinelly PintoRodolfo de Melo NunesVirgínia Cláudia Carneiro GirãoJosé Julio Costa SidrimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Francisco Airton Castro Rocha Anelise Maria Costa Vasconcelos Alves Marcos Fábio Gadelha Rocha Rossana de Aguiar Cordeiro Raimunda Sâmia Nogueira Brilhante Ana Carolina Matias Dinelly Pinto Rodolfo de Melo Nunes Virgínia Cláudia Carneiro Girão José Julio Costa Sidrim Tumor necrosis factor prevents Candida albicans biofilm formation
description	Abstract Candida species are commensals but some develop biofilms in prosthetic materials and host surfaces that may represent up to 30% of deaths related to infections, particularly in immunosuppressed patients. Tumor necrosis factor (TNF) exhibits a plethora of functions in host defense mechanisms whereas excessive release of TNF in inflammation promotes tissue damage. Cytokines released in an inflammatory milieu may influence the development of microorganisms either by promoting their growth or displaying antimicrobial activity. In protozoa, TNF may affect growth by coupling through a lectin-like domain, distinct from TNF receptors. TNF was also shown to interact with bacteria via a mechanism that does not involve classical TNF receptors. Using an in vitro C. albicans biofilm model, we show that TNF dose-dependently prevents biofilm development that is blocked by incubating TNF with N,N’-diacetylchitobiose, a major carbohydrate component of C. albicans cell wall. This finding represents a relevant and hitherto unknown mechanism that adds to the understanding of why TNF blockade is associated with opportunistic C. albicans infections.
format	article
author	Francisco Airton Castro Rocha Anelise Maria Costa Vasconcelos Alves Marcos Fábio Gadelha Rocha Rossana de Aguiar Cordeiro Raimunda Sâmia Nogueira Brilhante Ana Carolina Matias Dinelly Pinto Rodolfo de Melo Nunes Virgínia Cláudia Carneiro Girão José Julio Costa Sidrim
author_facet	Francisco Airton Castro Rocha Anelise Maria Costa Vasconcelos Alves Marcos Fábio Gadelha Rocha Rossana de Aguiar Cordeiro Raimunda Sâmia Nogueira Brilhante Ana Carolina Matias Dinelly Pinto Rodolfo de Melo Nunes Virgínia Cláudia Carneiro Girão José Julio Costa Sidrim
author_sort	Francisco Airton Castro Rocha
title	Tumor necrosis factor prevents Candida albicans biofilm formation
title_short	Tumor necrosis factor prevents Candida albicans biofilm formation
title_full	Tumor necrosis factor prevents Candida albicans biofilm formation
title_fullStr	Tumor necrosis factor prevents Candida albicans biofilm formation
title_full_unstemmed	Tumor necrosis factor prevents Candida albicans biofilm formation
title_sort	tumor necrosis factor prevents candida albicans biofilm formation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/19cc5543f09b4e64b00f345ec25d558c
work_keys_str_mv	AT franciscoairtoncastrorocha tumornecrosisfactorpreventscandidaalbicansbiofilmformation AT anelisemariacostavasconcelosalves tumornecrosisfactorpreventscandidaalbicansbiofilmformation AT marcosfabiogadelharocha tumornecrosisfactorpreventscandidaalbicansbiofilmformation AT rossanadeaguiarcordeiro tumornecrosisfactorpreventscandidaalbicansbiofilmformation AT raimundasamianogueirabrilhante tumornecrosisfactorpreventscandidaalbicansbiofilmformation AT anacarolinamatiasdinellypinto tumornecrosisfactorpreventscandidaalbicansbiofilmformation AT rodolfodemelonunes tumornecrosisfactorpreventscandidaalbicansbiofilmformation AT virginiaclaudiacarneirogirao tumornecrosisfactorpreventscandidaalbicansbiofilmformation AT josejuliocostasidrim tumornecrosisfactorpreventscandidaalbicansbiofilmformation
_version_	1718395565593591808

Tumor necrosis factor prevents Candida albicans biofilm formation

Ejemplares similares