Integrating Narcissus-derived galanthamine production into traditional upland farming systems

Abstract Alzheimer’s disease (AD) is a disorder associated with progressive degeneration of memory and cognitive function. Galantamine is a licenced treatment for AD but supplies of the plant alkaloid that it is produced from, galanthamine, are limited. This three-year system study tested the potent...

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Autores principales:	M. D. Fraser, H. E. Vallin, J. R. T. Davies, G. E. Rowlands, X. Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/19cd5b5da49a479e817facd61e311fc5
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spelling	oai:doaj.org-article:19cd5b5da49a479e817facd61e311fc52021-12-02T14:01:36ZIntegrating Narcissus-derived galanthamine production into traditional upland farming systems10.1038/s41598-021-81042-92045-2322https://doaj.org/article/19cd5b5da49a479e817facd61e311fc52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81042-9https://doaj.org/toc/2045-2322Abstract Alzheimer’s disease (AD) is a disorder associated with progressive degeneration of memory and cognitive function. Galantamine is a licenced treatment for AD but supplies of the plant alkaloid that it is produced from, galanthamine, are limited. This three-year system study tested the potential to combine Narcissus-derived galanthamine production with grassland-based ruminant production. Replicate plots of permanent pasture were prepared with and without bulbs of Narcissus pseudonarcissus sown as lines into the sward. Two different fertiliser regimes were imposed. The above-ground green biomass of N. pseudonarcissus was harvested in early spring and the galanthamine yield determined. In the second harvest year a split-plot design was implemented with lines of N. pseudonarcissus cut annually and biennially. All plots were subsequently grazed by ewes and lambs and animal performance recorded. Incorporation of N. pseudonarcissus into grazed permanent pasture had no detrimental effects on the health or performance of the sheep which subsequently grazed the pasture. There was no consistency to the effects of fertiliser rates on galanthamine yields. There was no difference in overall galanthamine yield if N. pseudonarcissus was cut biennially (1.64 vs. 1.75 kg galanthamine/ha for annual combined vs biennial cuts respectively; s.e.d = 0.117 kg galanthamine/ha; ns). This study verified the feasibility of a dual cropping approach to producing plant-derived galanthamine.M. D. FraserH. E. VallinJ. R. T. DaviesG. E. RowlandsX. ChangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. D. Fraser H. E. Vallin J. R. T. Davies G. E. Rowlands X. Chang Integrating Narcissus-derived galanthamine production into traditional upland farming systems
description	Abstract Alzheimer’s disease (AD) is a disorder associated with progressive degeneration of memory and cognitive function. Galantamine is a licenced treatment for AD but supplies of the plant alkaloid that it is produced from, galanthamine, are limited. This three-year system study tested the potential to combine Narcissus-derived galanthamine production with grassland-based ruminant production. Replicate plots of permanent pasture were prepared with and without bulbs of Narcissus pseudonarcissus sown as lines into the sward. Two different fertiliser regimes were imposed. The above-ground green biomass of N. pseudonarcissus was harvested in early spring and the galanthamine yield determined. In the second harvest year a split-plot design was implemented with lines of N. pseudonarcissus cut annually and biennially. All plots were subsequently grazed by ewes and lambs and animal performance recorded. Incorporation of N. pseudonarcissus into grazed permanent pasture had no detrimental effects on the health or performance of the sheep which subsequently grazed the pasture. There was no consistency to the effects of fertiliser rates on galanthamine yields. There was no difference in overall galanthamine yield if N. pseudonarcissus was cut biennially (1.64 vs. 1.75 kg galanthamine/ha for annual combined vs biennial cuts respectively; s.e.d = 0.117 kg galanthamine/ha; ns). This study verified the feasibility of a dual cropping approach to producing plant-derived galanthamine.
format	article
author	M. D. Fraser H. E. Vallin J. R. T. Davies G. E. Rowlands X. Chang
author_facet	M. D. Fraser H. E. Vallin J. R. T. Davies G. E. Rowlands X. Chang
author_sort	M. D. Fraser
title	Integrating Narcissus-derived galanthamine production into traditional upland farming systems
title_short	Integrating Narcissus-derived galanthamine production into traditional upland farming systems
title_full	Integrating Narcissus-derived galanthamine production into traditional upland farming systems
title_fullStr	Integrating Narcissus-derived galanthamine production into traditional upland farming systems
title_full_unstemmed	Integrating Narcissus-derived galanthamine production into traditional upland farming systems
title_sort	integrating narcissus-derived galanthamine production into traditional upland farming systems
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/19cd5b5da49a479e817facd61e311fc5
work_keys_str_mv	AT mdfraser integratingnarcissusderivedgalanthamineproductionintotraditionaluplandfarmingsystems AT hevallin integratingnarcissusderivedgalanthamineproductionintotraditionaluplandfarmingsystems AT jrtdavies integratingnarcissusderivedgalanthamineproductionintotraditionaluplandfarmingsystems AT gerowlands integratingnarcissusderivedgalanthamineproductionintotraditionaluplandfarmingsystems AT xchang integratingnarcissusderivedgalanthamineproductionintotraditionaluplandfarmingsystems
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Integrating Narcissus-derived galanthamine production into traditional upland farming systems

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