Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia

Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia

Abstract CD33/Sialic acid-binding Ig-like lectin 3 (SIGLEC3) is an innate immune receptor expressed on myeloid cells and mediates inhibitory signaling via tyrosine phosphatases. Variants of CD33 are associated with Alzheimer’s disease (AD) suggesting that modulation of CD33 signaling might be benefi...

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Autores principales: Jannis Wißfeld, Mona Mathews, Omar Mossad, Paola Picardi, Alessandro Cinti, Loredana Redaelli, Laurent Pradier, Oliver Brüstle, Harald Neumann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/19d23649beca49f89cee8a4250b51988
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