Oxepinamide F biosynthesis involves enzymatic d-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration

Oxepinamides are a class of fungal oxepins with biological activities. Here, the authors elucidate the biosynthetic pathway of oxepinamide F from Aspergillus ustus and show that it involves enyme-catalysed oxepin ring formation, hydroxylation-induced double bond migration, epimerization and methylat...

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Autores principales:	Liujuan Zheng, Haowen Wang, Aili Fan, Shu-Ming Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/19d314875dd346cd992bc74e173bb2bf
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spelling	oai:doaj.org-article:19d314875dd346cd992bc74e173bb2bf2021-12-02T19:16:55ZOxepinamide F biosynthesis involves enzymatic d-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration10.1038/s41467-020-18713-02041-1723https://doaj.org/article/19d314875dd346cd992bc74e173bb2bf2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18713-0https://doaj.org/toc/2041-1723Oxepinamides are a class of fungal oxepins with biological activities. Here, the authors elucidate the biosynthetic pathway of oxepinamide F from Aspergillus ustus and show that it involves enyme-catalysed oxepin ring formation, hydroxylation-induced double bond migration, epimerization and methylation.Liujuan ZhengHaowen WangAili FanShu-Ming LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liujuan Zheng Haowen Wang Aili Fan Shu-Ming Li Oxepinamide F biosynthesis involves enzymatic d-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration
description	Oxepinamides are a class of fungal oxepins with biological activities. Here, the authors elucidate the biosynthetic pathway of oxepinamide F from Aspergillus ustus and show that it involves enyme-catalysed oxepin ring formation, hydroxylation-induced double bond migration, epimerization and methylation.
format	article
author	Liujuan Zheng Haowen Wang Aili Fan Shu-Ming Li
author_facet	Liujuan Zheng Haowen Wang Aili Fan Shu-Ming Li
author_sort	Liujuan Zheng
title	Oxepinamide F biosynthesis involves enzymatic d-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration
title_short	Oxepinamide F biosynthesis involves enzymatic d-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration
title_full	Oxepinamide F biosynthesis involves enzymatic d-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration
title_fullStr	Oxepinamide F biosynthesis involves enzymatic d-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration
title_full_unstemmed	Oxepinamide F biosynthesis involves enzymatic d-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration
title_sort	oxepinamide f biosynthesis involves enzymatic d-aminoacyl epimerization, 3h-oxepin formation, and hydroxylation induced double bond migration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/19d314875dd346cd992bc74e173bb2bf
work_keys_str_mv	AT liujuanzheng oxepinamidefbiosynthesisinvolvesenzymaticdaminoacylepimerization3hoxepinformationandhydroxylationinduceddoublebondmigration AT haowenwang oxepinamidefbiosynthesisinvolvesenzymaticdaminoacylepimerization3hoxepinformationandhydroxylationinduceddoublebondmigration AT ailifan oxepinamidefbiosynthesisinvolvesenzymaticdaminoacylepimerization3hoxepinformationandhydroxylationinduceddoublebondmigration AT shumingli oxepinamidefbiosynthesisinvolvesenzymaticdaminoacylepimerization3hoxepinformationandhydroxylationinduceddoublebondmigration
_version_	1718376899621683200

Oxepinamide F biosynthesis involves enzymatic d-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration

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