The role of insulin C-peptide in the coevolution analyses of the insulin signaling pathway: a hint for its functions.

As the linker between the A chain and B chain of proinsulin, C-peptide displays high variability in length and amino acid composition, and has been considered as an inert byproduct of insulin synthesis and processing for many years. Recent studies have suggested that C-peptide can act as a bioactive...

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Autores principales:	Shuai Wang, Wei Wei, Yadong Zheng, Junling Hou, Yongxi Dou, Shaohua Zhang, Xuenong Luo, Xuepeng Cai
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/19d3cb7e42db44cbb6080d84b7d91a04
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spelling	oai:doaj.org-article:19d3cb7e42db44cbb6080d84b7d91a042021-11-18T08:03:27ZThe role of insulin C-peptide in the coevolution analyses of the insulin signaling pathway: a hint for its functions.1932-620310.1371/journal.pone.0052847https://doaj.org/article/19d3cb7e42db44cbb6080d84b7d91a042012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300796/?tool=EBIhttps://doaj.org/toc/1932-6203As the linker between the A chain and B chain of proinsulin, C-peptide displays high variability in length and amino acid composition, and has been considered as an inert byproduct of insulin synthesis and processing for many years. Recent studies have suggested that C-peptide can act as a bioactive hormone, exerting various biological effects on the pathophysiology and treatment of diabetes. In this study, we analyzed the coevolution of insulin molecules among vertebrates, aiming at exploring the evolutionary characteristics of insulin molecule, especially the C-peptide. We also calculated the correlations of evolutionary rates between the insulin and the insulin receptor (IR) sequences as well as the domain-domain pairs of the ligand and receptor by the mirrortree method. The results revealed distinctive features of C-peptide in insulin intramolecular coevolution and correlated residue substitutions, which partly supported the idea that C-peptide can act as a bioactive hormone, with significant sequence features, as well as a linker assisting the formation of mature insulin during synthesis. Interestingly, the evolution of C-peptide exerted the highest correlation with that of the insulin receptor and its ligand binding domain (LBD), implying a potential relationship with the insulin signaling pathway.Shuai WangWei WeiYadong ZhengJunling HouYongxi DouShaohua ZhangXuenong LuoXuepeng CaiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52847 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shuai Wang Wei Wei Yadong Zheng Junling Hou Yongxi Dou Shaohua Zhang Xuenong Luo Xuepeng Cai The role of insulin C-peptide in the coevolution analyses of the insulin signaling pathway: a hint for its functions.
description	As the linker between the A chain and B chain of proinsulin, C-peptide displays high variability in length and amino acid composition, and has been considered as an inert byproduct of insulin synthesis and processing for many years. Recent studies have suggested that C-peptide can act as a bioactive hormone, exerting various biological effects on the pathophysiology and treatment of diabetes. In this study, we analyzed the coevolution of insulin molecules among vertebrates, aiming at exploring the evolutionary characteristics of insulin molecule, especially the C-peptide. We also calculated the correlations of evolutionary rates between the insulin and the insulin receptor (IR) sequences as well as the domain-domain pairs of the ligand and receptor by the mirrortree method. The results revealed distinctive features of C-peptide in insulin intramolecular coevolution and correlated residue substitutions, which partly supported the idea that C-peptide can act as a bioactive hormone, with significant sequence features, as well as a linker assisting the formation of mature insulin during synthesis. Interestingly, the evolution of C-peptide exerted the highest correlation with that of the insulin receptor and its ligand binding domain (LBD), implying a potential relationship with the insulin signaling pathway.
format	article
author	Shuai Wang Wei Wei Yadong Zheng Junling Hou Yongxi Dou Shaohua Zhang Xuenong Luo Xuepeng Cai
author_facet	Shuai Wang Wei Wei Yadong Zheng Junling Hou Yongxi Dou Shaohua Zhang Xuenong Luo Xuepeng Cai
author_sort	Shuai Wang
title	The role of insulin C-peptide in the coevolution analyses of the insulin signaling pathway: a hint for its functions.
title_short	The role of insulin C-peptide in the coevolution analyses of the insulin signaling pathway: a hint for its functions.
title_full	The role of insulin C-peptide in the coevolution analyses of the insulin signaling pathway: a hint for its functions.
title_fullStr	The role of insulin C-peptide in the coevolution analyses of the insulin signaling pathway: a hint for its functions.
title_full_unstemmed	The role of insulin C-peptide in the coevolution analyses of the insulin signaling pathway: a hint for its functions.
title_sort	role of insulin c-peptide in the coevolution analyses of the insulin signaling pathway: a hint for its functions.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/19d3cb7e42db44cbb6080d84b7d91a04
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The role of insulin C-peptide in the coevolution analyses of the insulin signaling pathway: a hint for its functions.

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