Troponin and anti-troponin autoantibody levels in patients with ventricular noncompaction.

Ventricular hypertrabeculation/noncompaction is a morphologic and functional anomaly of myocardium characterized by prominent trabeculae accompanied by deep recessus. Dilated cardiomyopathy with left ventricular failure is observed in these patients, while the cause or pathophysiologic nature of thi...

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Autores principales:	Hatice Betül Erer, Tolga Sinan Güvenç, Ahu Sarbay Kemik, Hale Yaka Yılmaz, Şeref Kul, Servet Altay, Nurten Sayar, Yüksel Kaya, Mehmet Eren
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/19d4f5469f074539b0ce42747153d10c
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spelling	oai:doaj.org-article:19d4f5469f074539b0ce42747153d10c2021-11-18T07:55:26ZTroponin and anti-troponin autoantibody levels in patients with ventricular noncompaction.1932-620310.1371/journal.pone.0057648https://doaj.org/article/19d4f5469f074539b0ce42747153d10c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23469039/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Ventricular hypertrabeculation/noncompaction is a morphologic and functional anomaly of myocardium characterized by prominent trabeculae accompanied by deep recessus. Dilated cardiomyopathy with left ventricular failure is observed in these patients, while the cause or pathophysiologic nature of this complication is not known. Anti-troponin antibodies are formed against circulating cardiac troponins after an acute coronary event or conditions associated with chronic myocyte necrosis, such as dilated cardiomyopathy. In present study, we aimed to investigate cardiac troponins and anti troponin autoantibodies in ventricular noncompaction/hypertrabeculation patients with/without reduced ejection fraction. A total of 50 patients with ventricular noncompaction and 23 healthy volunteers were included in this study. Noncompaction/hypertrabeculation was diagnosed with two-dimensional echocardiography using appropriate criteria. Depending on ejection fraction, patients were grouped into noncompaction with preserved EF (LVEF >50%, n = 24) and noncompaction with reduced EF (LVEF <35%, n = 26) groups. Troponin I, troponin T, anti-troponin I IgM and anti-troponin T IgM were measured with sandwich immunoassay method using a commercially available kit. Patients with noncompaction had significantly higher troponin I (28.98±9.21 ng/ml in NCNE group and 28.11±10.42 ng/ml in NCLE group), troponin T (22.17±6.97 pg/ml in NCNE group and 22.78±7.76 pg/ml in NCLE group) and antitroponin I IgM (1.92±0.43 µg/ml in NCNE group and 1.79±0.36 µg/ml in NCLE group) levels compared to control group, while antitroponin T IgM and IgG were only elevated in patients with noncompaction and reduced EF (15.81±6.52 µg/ml for IgM and 16.46±6.25 µg/ml for IgG). Elevated cardiac troponins and anti-troponin I autoantibodies were observed in patients with noncompaction preceding the decline in systolic function and could indicate ongoing myocardial damage in these patients.Hatice Betül ErerTolga Sinan GüvençAhu Sarbay KemikHale Yaka YılmazŞeref KulServet AltayNurten SayarYüksel KayaMehmet ErenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e57648 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hatice Betül Erer Tolga Sinan Güvenç Ahu Sarbay Kemik Hale Yaka Yılmaz Şeref Kul Servet Altay Nurten Sayar Yüksel Kaya Mehmet Eren Troponin and anti-troponin autoantibody levels in patients with ventricular noncompaction.
description	Ventricular hypertrabeculation/noncompaction is a morphologic and functional anomaly of myocardium characterized by prominent trabeculae accompanied by deep recessus. Dilated cardiomyopathy with left ventricular failure is observed in these patients, while the cause or pathophysiologic nature of this complication is not known. Anti-troponin antibodies are formed against circulating cardiac troponins after an acute coronary event or conditions associated with chronic myocyte necrosis, such as dilated cardiomyopathy. In present study, we aimed to investigate cardiac troponins and anti troponin autoantibodies in ventricular noncompaction/hypertrabeculation patients with/without reduced ejection fraction. A total of 50 patients with ventricular noncompaction and 23 healthy volunteers were included in this study. Noncompaction/hypertrabeculation was diagnosed with two-dimensional echocardiography using appropriate criteria. Depending on ejection fraction, patients were grouped into noncompaction with preserved EF (LVEF >50%, n = 24) and noncompaction with reduced EF (LVEF <35%, n = 26) groups. Troponin I, troponin T, anti-troponin I IgM and anti-troponin T IgM were measured with sandwich immunoassay method using a commercially available kit. Patients with noncompaction had significantly higher troponin I (28.98±9.21 ng/ml in NCNE group and 28.11±10.42 ng/ml in NCLE group), troponin T (22.17±6.97 pg/ml in NCNE group and 22.78±7.76 pg/ml in NCLE group) and antitroponin I IgM (1.92±0.43 µg/ml in NCNE group and 1.79±0.36 µg/ml in NCLE group) levels compared to control group, while antitroponin T IgM and IgG were only elevated in patients with noncompaction and reduced EF (15.81±6.52 µg/ml for IgM and 16.46±6.25 µg/ml for IgG). Elevated cardiac troponins and anti-troponin I autoantibodies were observed in patients with noncompaction preceding the decline in systolic function and could indicate ongoing myocardial damage in these patients.
format	article
author	Hatice Betül Erer Tolga Sinan Güvenç Ahu Sarbay Kemik Hale Yaka Yılmaz Şeref Kul Servet Altay Nurten Sayar Yüksel Kaya Mehmet Eren
author_facet	Hatice Betül Erer Tolga Sinan Güvenç Ahu Sarbay Kemik Hale Yaka Yılmaz Şeref Kul Servet Altay Nurten Sayar Yüksel Kaya Mehmet Eren
author_sort	Hatice Betül Erer
title	Troponin and anti-troponin autoantibody levels in patients with ventricular noncompaction.
title_short	Troponin and anti-troponin autoantibody levels in patients with ventricular noncompaction.
title_full	Troponin and anti-troponin autoantibody levels in patients with ventricular noncompaction.
title_fullStr	Troponin and anti-troponin autoantibody levels in patients with ventricular noncompaction.
title_full_unstemmed	Troponin and anti-troponin autoantibody levels in patients with ventricular noncompaction.
title_sort	troponin and anti-troponin autoantibody levels in patients with ventricular noncompaction.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/19d4f5469f074539b0ce42747153d10c
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Troponin and anti-troponin autoantibody levels in patients with ventricular noncompaction.

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