Newly Found Peacekeeper: Potential of CD8+ Tregs for Graft-Versus-Host Disease

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the most effective and potentially curative treatment for a variety of hematologic malignancies. However, graft-versus-host disease (GVHD) is a major obstacle that limits wide application of allo-HSCT, despite the development of...

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Autores principales:	Weihao Wang, Tao Hong, Xiaoqi Wang, Rui Wang, Yuxuan Du, Qiangguo Gao, Shijie Yang, Xi Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hematopoietic stem cell transplantation graft-versus-host disease CD8 CD4 regulatory T cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/19d87cc340ac47ea9aef36eb8a677dec
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spelling	oai:doaj.org-article:19d87cc340ac47ea9aef36eb8a677dec2021-11-30T19:16:48ZNewly Found Peacekeeper: Potential of CD8+ Tregs for Graft-Versus-Host Disease1664-322410.3389/fimmu.2021.764786https://doaj.org/article/19d87cc340ac47ea9aef36eb8a677dec2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.764786/fullhttps://doaj.org/toc/1664-3224Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the most effective and potentially curative treatment for a variety of hematologic malignancies. However, graft-versus-host disease (GVHD) is a major obstacle that limits wide application of allo-HSCT, despite the development of prophylactic strategies. Owing to experimental and clinical advances in the field, GVHD is characterized by disruption of the balance between effector and regulatory immune cells, resulting in higher inflammatory cytokine levels. A reduction in regulatory T cells (Tregs) has been associated with limiting recalibration of inflammatory overaction and maintaining immune tolerance. Moreover, accumulating evidence suggests that immunoregulation may be useful for preventing GVHD. As opposed to CD4+ Tregs, the CD8+ Tregs population, which constitutes an important proportion of all Tregs, efficiently attenuates GVHD while sparing graft-versus-leukemic (GVL) effects. CD8+ Tregs may provide another form of cellular therapy for preventing GVHD and preserving GVL effects, and understanding the underlying mechanisms that different from those of CD4+ Tregs is significant. In this review, we summarize preclinical experiments that have demonstrated the role of CD8+ Tregs during GVHD and attempted to obtain optimized CD8+ Tregs. Notably, although optimized CD8+ Tregs have obvious advantages, more exploration is needed to determine how to apply them in the clinic.Weihao WangWeihao WangTao HongTao HongXiaoqi WangXiaoqi WangRui WangRui WangYuxuan DuYuxuan DuYuxuan DuQiangguo GaoShijie YangShijie YangXi ZhangXi ZhangFrontiers Media S.A.articlehematopoietic stem cell transplantationgraft-versus-host diseaseCD8CD4regulatory T cellsImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hematopoietic stem cell transplantation graft-versus-host disease CD8 CD4 regulatory T cells Immunologic diseases. Allergy RC581-607
spellingShingle	hematopoietic stem cell transplantation graft-versus-host disease CD8 CD4 regulatory T cells Immunologic diseases. Allergy RC581-607 Weihao Wang Weihao Wang Tao Hong Tao Hong Xiaoqi Wang Xiaoqi Wang Rui Wang Rui Wang Yuxuan Du Yuxuan Du Yuxuan Du Qiangguo Gao Shijie Yang Shijie Yang Xi Zhang Xi Zhang Newly Found Peacekeeper: Potential of CD8+ Tregs for Graft-Versus-Host Disease
description	Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the most effective and potentially curative treatment for a variety of hematologic malignancies. However, graft-versus-host disease (GVHD) is a major obstacle that limits wide application of allo-HSCT, despite the development of prophylactic strategies. Owing to experimental and clinical advances in the field, GVHD is characterized by disruption of the balance between effector and regulatory immune cells, resulting in higher inflammatory cytokine levels. A reduction in regulatory T cells (Tregs) has been associated with limiting recalibration of inflammatory overaction and maintaining immune tolerance. Moreover, accumulating evidence suggests that immunoregulation may be useful for preventing GVHD. As opposed to CD4+ Tregs, the CD8+ Tregs population, which constitutes an important proportion of all Tregs, efficiently attenuates GVHD while sparing graft-versus-leukemic (GVL) effects. CD8+ Tregs may provide another form of cellular therapy for preventing GVHD and preserving GVL effects, and understanding the underlying mechanisms that different from those of CD4+ Tregs is significant. In this review, we summarize preclinical experiments that have demonstrated the role of CD8+ Tregs during GVHD and attempted to obtain optimized CD8+ Tregs. Notably, although optimized CD8+ Tregs have obvious advantages, more exploration is needed to determine how to apply them in the clinic.
format	article
author	Weihao Wang Weihao Wang Tao Hong Tao Hong Xiaoqi Wang Xiaoqi Wang Rui Wang Rui Wang Yuxuan Du Yuxuan Du Yuxuan Du Qiangguo Gao Shijie Yang Shijie Yang Xi Zhang Xi Zhang
author_facet	Weihao Wang Weihao Wang Tao Hong Tao Hong Xiaoqi Wang Xiaoqi Wang Rui Wang Rui Wang Yuxuan Du Yuxuan Du Yuxuan Du Qiangguo Gao Shijie Yang Shijie Yang Xi Zhang Xi Zhang
author_sort	Weihao Wang
title	Newly Found Peacekeeper: Potential of CD8+ Tregs for Graft-Versus-Host Disease
title_short	Newly Found Peacekeeper: Potential of CD8+ Tregs for Graft-Versus-Host Disease
title_full	Newly Found Peacekeeper: Potential of CD8+ Tregs for Graft-Versus-Host Disease
title_fullStr	Newly Found Peacekeeper: Potential of CD8+ Tregs for Graft-Versus-Host Disease
title_full_unstemmed	Newly Found Peacekeeper: Potential of CD8+ Tregs for Graft-Versus-Host Disease
title_sort	newly found peacekeeper: potential of cd8+ tregs for graft-versus-host disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/19d87cc340ac47ea9aef36eb8a677dec
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Newly Found Peacekeeper: Potential of CD8+ Tregs for Graft-Versus-Host Disease

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