Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge

Genodermatoses represent a group of uncommon, hereditary, single-gene skin disorders, characterized by multisystem involvement, heterogeneous clinical manifestations and different degrees of morbidity and mortality. Some genodermatoses may have oral mucosa and nail involvement, since the oral cavity...

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Autores principales:	Tiziana Cantile, Noemi Coppola, Vito Carlo Alberto Caponio, Daniela Russo, Paolo Bucci, Gianrico Spagnuolo, Michele Davide Mignogna, Stefania Leuci
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	genodermatoses genetic diseases oral mucosa nails dermatology oral medicine Medicine R
Acceso en línea:	https://doaj.org/article/19d8d75b1ad64f2bbece52bd3772abbf
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spelling	oai:doaj.org-article:19d8d75b1ad64f2bbece52bd3772abbf2021-11-25T18:02:29ZOral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge10.3390/jcm102254042077-0383https://doaj.org/article/19d8d75b1ad64f2bbece52bd3772abbf2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5404https://doaj.org/toc/2077-0383Genodermatoses represent a group of uncommon, hereditary, single-gene skin disorders, characterized by multisystem involvement, heterogeneous clinical manifestations and different degrees of morbidity and mortality. Some genodermatoses may have oral mucosa and nail involvement, since the oral cavity and cutaneous organ system, including nails, share a close embryologic origin. Nail disorders can manifest with nail hypoplasia or nail hypertrophy. Clinical pictures of affected oral mucosa can be extremely heterogeneous, ranging from asymptomatic papules to painful blisters, leukokeratosis, oral papillomas and fibromas to oral potentially malignant disorders and cancerous lesions. Oral mucosa and nails pathological features may occur synchronously or not and are usually associated with other systemic and skin manifestations. In some cases, oral mucosa and nails diseases may be distinct and constitute the principal sign of the genetic disorder, in other cases they represent only a part of the puzzle for the confirmation of the diagnosis. Continued awareness of the correlation between oral mucosa and nails findings can help physicians to diagnose genodermatosis in a timely manner, allowing more effective clinical management and prevention and/or early detection of complications. This article provides an overview of all specific genodermatoses affecting both oral mucosa and nails. Moreover, the correlation between teeth and nails is summarized in tabular form.Tiziana CantileNoemi CoppolaVito Carlo Alberto CaponioDaniela RussoPaolo BucciGianrico SpagnuoloMichele Davide MignognaStefania LeuciMDPI AGarticlegenodermatosesgenetic diseasesoral mucosanailsdermatologyoral medicineMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5404, p 5404 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	genodermatoses genetic diseases oral mucosa nails dermatology oral medicine Medicine R
spellingShingle	genodermatoses genetic diseases oral mucosa nails dermatology oral medicine Medicine R Tiziana Cantile Noemi Coppola Vito Carlo Alberto Caponio Daniela Russo Paolo Bucci Gianrico Spagnuolo Michele Davide Mignogna Stefania Leuci Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge
description	Genodermatoses represent a group of uncommon, hereditary, single-gene skin disorders, characterized by multisystem involvement, heterogeneous clinical manifestations and different degrees of morbidity and mortality. Some genodermatoses may have oral mucosa and nail involvement, since the oral cavity and cutaneous organ system, including nails, share a close embryologic origin. Nail disorders can manifest with nail hypoplasia or nail hypertrophy. Clinical pictures of affected oral mucosa can be extremely heterogeneous, ranging from asymptomatic papules to painful blisters, leukokeratosis, oral papillomas and fibromas to oral potentially malignant disorders and cancerous lesions. Oral mucosa and nails pathological features may occur synchronously or not and are usually associated with other systemic and skin manifestations. In some cases, oral mucosa and nails diseases may be distinct and constitute the principal sign of the genetic disorder, in other cases they represent only a part of the puzzle for the confirmation of the diagnosis. Continued awareness of the correlation between oral mucosa and nails findings can help physicians to diagnose genodermatosis in a timely manner, allowing more effective clinical management and prevention and/or early detection of complications. This article provides an overview of all specific genodermatoses affecting both oral mucosa and nails. Moreover, the correlation between teeth and nails is summarized in tabular form.
format	article
author	Tiziana Cantile Noemi Coppola Vito Carlo Alberto Caponio Daniela Russo Paolo Bucci Gianrico Spagnuolo Michele Davide Mignogna Stefania Leuci
author_facet	Tiziana Cantile Noemi Coppola Vito Carlo Alberto Caponio Daniela Russo Paolo Bucci Gianrico Spagnuolo Michele Davide Mignogna Stefania Leuci
author_sort	Tiziana Cantile
title	Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge
title_short	Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge
title_full	Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge
title_fullStr	Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge
title_full_unstemmed	Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge
title_sort	oral mucosa and nails in genodermatoses: a diagnostic challenge
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/19d8d75b1ad64f2bbece52bd3772abbf
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Oral Mucosa and Nails in Genodermatoses: A Diagnostic Challenge

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