Topical rebamipide improves the ocular surface in mild lagophthalmos

Mariko Itakura,1 Hirotaka Itakura,1,2 Tomoyuki Kashima,2 Hideo Akiyama,2 Shoji Kishi21Department of Ophthalmology, Maebashi Red Cross Hospital, Maebashi, Japan; 2Department of Ophthalmology, Gunma University, School of Medicine, Maebashi, JapanAbstract: Administration of topical rebamipide improves...

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Autores principales:	Itakura M, Itakura H, Kashima T, Akiyama H, Kishi S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/19dc18f17f4c4cd28a2cf0fed90dc273
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spelling	oai:doaj.org-article:19dc18f17f4c4cd28a2cf0fed90dc2732021-12-02T09:31:29ZTopical rebamipide improves the ocular surface in mild lagophthalmos1177-54671177-5483https://doaj.org/article/19dc18f17f4c4cd28a2cf0fed90dc2732013-07-01T00:00:00Zhttp://www.dovepress.com/topical-rebamipide-improves-the-ocular-surface-in-mild-lagophthalmos-a13528https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Mariko Itakura,1 Hirotaka Itakura,1,2 Tomoyuki Kashima,2 Hideo Akiyama,2 Shoji Kishi21Department of Ophthalmology, Maebashi Red Cross Hospital, Maebashi, Japan; 2Department of Ophthalmology, Gunma University, School of Medicine, Maebashi, JapanAbstract: Administration of topical rebamipide improves the ocular surface in dry eye. We consecutively studied seven eyes in seven cases (three males and four females) with mild lagophthalmos (three cases after eyelid surgery, two cases of incomplete facial nerve palsy, and two cases of senile ectropion) during the treatment of corneal disorders with rebamipide eye drops four times daily for 2 weeks. The fluorescein corneal staining (FCS) score, tear film break-up time (TBUT), Schirmer's test, and decimal visual acuity were examined. Ocular symptoms were examined and scored by questioning each patient before and after administration of the drug. In all seven eyes, inferior corneal erosion decreased or disappeared within 2 weeks after administration of topical rebamipide. The FCS score was significantly improved (P < 0.05). The TBUT was significantly extended from 2.9 ± 0.5 seconds to 5.2 ± 0.4 seconds (P < 0.05). The scores of ocular symptoms, such as eye pain, dryness, blurred vision, and foreign body sensations, were significantly improved (P < 0.05).Topical rebamipide was effective for corneal disorders in mild lagophthalmos. This drug may provide a novel approach to treat lagophthalmos.Keywords: dry eye, ectropion, eyelid surgery, facial nerve palsy, lagophthalmos, rebamipideItakura MItakura HKashima TAkiyama HKishi SDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1333-1338 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Itakura M Itakura H Kashima T Akiyama H Kishi S Topical rebamipide improves the ocular surface in mild lagophthalmos
description	Mariko Itakura,1 Hirotaka Itakura,1,2 Tomoyuki Kashima,2 Hideo Akiyama,2 Shoji Kishi21Department of Ophthalmology, Maebashi Red Cross Hospital, Maebashi, Japan; 2Department of Ophthalmology, Gunma University, School of Medicine, Maebashi, JapanAbstract: Administration of topical rebamipide improves the ocular surface in dry eye. We consecutively studied seven eyes in seven cases (three males and four females) with mild lagophthalmos (three cases after eyelid surgery, two cases of incomplete facial nerve palsy, and two cases of senile ectropion) during the treatment of corneal disorders with rebamipide eye drops four times daily for 2 weeks. The fluorescein corneal staining (FCS) score, tear film break-up time (TBUT), Schirmer's test, and decimal visual acuity were examined. Ocular symptoms were examined and scored by questioning each patient before and after administration of the drug. In all seven eyes, inferior corneal erosion decreased or disappeared within 2 weeks after administration of topical rebamipide. The FCS score was significantly improved (P < 0.05). The TBUT was significantly extended from 2.9 ± 0.5 seconds to 5.2 ± 0.4 seconds (P < 0.05). The scores of ocular symptoms, such as eye pain, dryness, blurred vision, and foreign body sensations, were significantly improved (P < 0.05).Topical rebamipide was effective for corneal disorders in mild lagophthalmos. This drug may provide a novel approach to treat lagophthalmos.Keywords: dry eye, ectropion, eyelid surgery, facial nerve palsy, lagophthalmos, rebamipide
format	article
author	Itakura M Itakura H Kashima T Akiyama H Kishi S
author_facet	Itakura M Itakura H Kashima T Akiyama H Kishi S
author_sort	Itakura M
title	Topical rebamipide improves the ocular surface in mild lagophthalmos
title_short	Topical rebamipide improves the ocular surface in mild lagophthalmos
title_full	Topical rebamipide improves the ocular surface in mild lagophthalmos
title_fullStr	Topical rebamipide improves the ocular surface in mild lagophthalmos
title_full_unstemmed	Topical rebamipide improves the ocular surface in mild lagophthalmos
title_sort	topical rebamipide improves the ocular surface in mild lagophthalmos
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/19dc18f17f4c4cd28a2cf0fed90dc273
work_keys_str_mv	AT itakuram topicalrebamipideimprovestheocularsurfaceinmildlagophthalmos AT itakurah topicalrebamipideimprovestheocularsurfaceinmildlagophthalmos AT kashimat topicalrebamipideimprovestheocularsurfaceinmildlagophthalmos AT akiyamah topicalrebamipideimprovestheocularsurfaceinmildlagophthalmos AT kishis topicalrebamipideimprovestheocularsurfaceinmildlagophthalmos
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Topical rebamipide improves the ocular surface in mild lagophthalmos

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