Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2

The free fatty acid-mediated inflammatory activities are regulated through TLR4. Here the authors show that palmitic acid binds to MD2, initiating complex formation with TLR4, recruitment of MyD88, and subsequent activation of pro-inflammatory molecules, and that MD2 blockade protects against diet-i...

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Autores principales:	Yi Wang, Yuanyuan Qian, Qilu Fang, Peng Zhong, Weixin Li, Lintao Wang, Weitao Fu, Yali Zhang, Zheng Xu, Xiaokun Li, Guang Liang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/19de1d0ca54b48c0bfd139388f9f4612
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spelling	oai:doaj.org-article:19de1d0ca54b48c0bfd139388f9f46122021-12-02T15:38:35ZSaturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD210.1038/ncomms139972041-1723https://doaj.org/article/19de1d0ca54b48c0bfd139388f9f46122017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13997https://doaj.org/toc/2041-1723The free fatty acid-mediated inflammatory activities are regulated through TLR4. Here the authors show that palmitic acid binds to MD2, initiating complex formation with TLR4, recruitment of MyD88, and subsequent activation of pro-inflammatory molecules, and that MD2 blockade protects against diet-induced cardiac dysfunction.Yi WangYuanyuan QianQilu FangPeng ZhongWeixin LiLintao WangWeitao FuYali ZhangZheng XuXiaokun LiGuang LiangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi Wang Yuanyuan Qian Qilu Fang Peng Zhong Weixin Li Lintao Wang Weitao Fu Yali Zhang Zheng Xu Xiaokun Li Guang Liang Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2
description	The free fatty acid-mediated inflammatory activities are regulated through TLR4. Here the authors show that palmitic acid binds to MD2, initiating complex formation with TLR4, recruitment of MyD88, and subsequent activation of pro-inflammatory molecules, and that MD2 blockade protects against diet-induced cardiac dysfunction.
format	article
author	Yi Wang Yuanyuan Qian Qilu Fang Peng Zhong Weixin Li Lintao Wang Weitao Fu Yali Zhang Zheng Xu Xiaokun Li Guang Liang
author_facet	Yi Wang Yuanyuan Qian Qilu Fang Peng Zhong Weixin Li Lintao Wang Weitao Fu Yali Zhang Zheng Xu Xiaokun Li Guang Liang
author_sort	Yi Wang
title	Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2
title_short	Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2
title_full	Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2
title_fullStr	Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2
title_full_unstemmed	Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2
title_sort	saturated palmitic acid induces myocardial inflammatory injuries through direct binding to tlr4 accessory protein md2
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/19de1d0ca54b48c0bfd139388f9f4612
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Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2

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