Can androgen-deprivation therapy obviate the need of channel transurethral resection of the prostate in advanced prostate cancer with urinary retention? A prospective study

Objective: To evaluate the efficacy of androgen-deprivation therapy (ADT) in relieving urinary retention in patients with advanced prostate cancer presenting with urinary retention or a high post-void residual urine volume (PVR). Patients and methods: Patients with advanced prostate cancer with an i...

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Autores principales:	Rajeev Sood, Ritesh Kumar Singh, Hemant Goel, T. Manasa, Nikhil Khattar, Mahesh C. Tripathi
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2017
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/19de87334de04e53b114bd692ff4c3b6
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spelling	oai:doaj.org-article:19de87334de04e53b114bd692ff4c3b62021-12-02T13:03:31ZCan androgen-deprivation therapy obviate the need of channel transurethral resection of the prostate in advanced prostate cancer with urinary retention? A prospective study2090-598X10.1016/j.aju.2017.08.005https://doaj.org/article/19de87334de04e53b114bd692ff4c3b62017-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X17301031https://doaj.org/toc/2090-598XObjective: To evaluate the efficacy of androgen-deprivation therapy (ADT) in relieving urinary retention in patients with advanced prostate cancer presenting with urinary retention or a high post-void residual urine volume (PVR). Patients and methods: Patients with advanced prostate cancer with an indwelling catheter for acute/chronic urinary retention, or with a high PVR (>200Â mL) who had not received any previous treatment were included in the study. Patients with localised prostate cancer eligible for receiving any therapy aimed at cure were excluded. All enrolled patients were managed by ADT (LHRH antagonist/agonist or orchidectomy) combined with Î±-adrenoceptor antagonist/combined therapy for at least 1Â month to a maximum of 3Â months; they were given their first trial of voiding without catheter after 1Â month, and monthly thereafter. Results: A total of 101 patients received ADT of which 97 were able to void successfully at the end of 3Â months. In all, 27 patients could void in the first month, followed by 50 in the second month, and an additional 20 in the third month. There was a significant decrease in prostate volume, PVR, and International Prostate Symptom Score, and maximum urinary flow rates improved with normalisation of renal functions and resolution of upper tract changes noted on ultrasonography. Conclusion: ADT can relieve retention and decrease PVR over a period of time obviating the need for channel transurethral resection of the prostate. Keywords: ADT, ADT in retention, Prostate cancerRajeev SoodRitesh Kumar SinghHemant GoelT. ManasaNikhil KhattarMahesh C. TripathiTaylor & Francis GrouparticleDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 15, Iss 4, Pp 339-346 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Rajeev Sood Ritesh Kumar Singh Hemant Goel T. Manasa Nikhil Khattar Mahesh C. Tripathi Can androgen-deprivation therapy obviate the need of channel transurethral resection of the prostate in advanced prostate cancer with urinary retention? A prospective study
description	Objective: To evaluate the efficacy of androgen-deprivation therapy (ADT) in relieving urinary retention in patients with advanced prostate cancer presenting with urinary retention or a high post-void residual urine volume (PVR). Patients and methods: Patients with advanced prostate cancer with an indwelling catheter for acute/chronic urinary retention, or with a high PVR (>200Â mL) who had not received any previous treatment were included in the study. Patients with localised prostate cancer eligible for receiving any therapy aimed at cure were excluded. All enrolled patients were managed by ADT (LHRH antagonist/agonist or orchidectomy) combined with Î±-adrenoceptor antagonist/combined therapy for at least 1Â month to a maximum of 3Â months; they were given their first trial of voiding without catheter after 1Â month, and monthly thereafter. Results: A total of 101 patients received ADT of which 97 were able to void successfully at the end of 3Â months. In all, 27 patients could void in the first month, followed by 50 in the second month, and an additional 20 in the third month. There was a significant decrease in prostate volume, PVR, and International Prostate Symptom Score, and maximum urinary flow rates improved with normalisation of renal functions and resolution of upper tract changes noted on ultrasonography. Conclusion: ADT can relieve retention and decrease PVR over a period of time obviating the need for channel transurethral resection of the prostate. Keywords: ADT, ADT in retention, Prostate cancer
format	article
author	Rajeev Sood Ritesh Kumar Singh Hemant Goel T. Manasa Nikhil Khattar Mahesh C. Tripathi
author_facet	Rajeev Sood Ritesh Kumar Singh Hemant Goel T. Manasa Nikhil Khattar Mahesh C. Tripathi
author_sort	Rajeev Sood
title	Can androgen-deprivation therapy obviate the need of channel transurethral resection of the prostate in advanced prostate cancer with urinary retention? A prospective study
title_short	Can androgen-deprivation therapy obviate the need of channel transurethral resection of the prostate in advanced prostate cancer with urinary retention? A prospective study
title_full	Can androgen-deprivation therapy obviate the need of channel transurethral resection of the prostate in advanced prostate cancer with urinary retention? A prospective study
title_fullStr	Can androgen-deprivation therapy obviate the need of channel transurethral resection of the prostate in advanced prostate cancer with urinary retention? A prospective study
title_full_unstemmed	Can androgen-deprivation therapy obviate the need of channel transurethral resection of the prostate in advanced prostate cancer with urinary retention? A prospective study
title_sort	can androgen-deprivation therapy obviate the need of channel transurethral resection of the prostate in advanced prostate cancer with urinary retention? a prospective study
publisher	Taylor & Francis Group
publishDate	2017
url	https://doaj.org/article/19de87334de04e53b114bd692ff4c3b6
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Can androgen-deprivation therapy obviate the need of channel transurethral resection of the prostate in advanced prostate cancer with urinary retention? A prospective study

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