Biomineralized Composite Liquid Crystal Fiber Scaffold Promotes Bone Regeneration by Enhancement of Osteogenesis and Angiogenesis

Liquid crystals (LCs) are appealing biomaterials for applications in bone regenerative medicine due to their tunable physical properties and anisotropic viscoelastic behavior. This study reports a novel composite poly (L-lactide) (PLLA) scaffold that is manufactured by a simple electrospinning and b...

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Autores principales:	Yi Zhan, Bing Deng, Huixian Wu, Changpeng Xu, Ruiying Wang, Wenqiang Li, Zhixiong Pan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	liquid crystal fiber biomimetic mineralization osteogenic differentiation vascularization regeneration Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/19df11f067eb4317af9af98c6097bf4e
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spelling	oai:doaj.org-article:19df11f067eb4317af9af98c6097bf4e2021-11-08T04:52:34ZBiomineralized Composite Liquid Crystal Fiber Scaffold Promotes Bone Regeneration by Enhancement of Osteogenesis and Angiogenesis1663-981210.3389/fphar.2021.736301https://doaj.org/article/19df11f067eb4317af9af98c6097bf4e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.736301/fullhttps://doaj.org/toc/1663-9812Liquid crystals (LCs) are appealing biomaterials for applications in bone regenerative medicine due to their tunable physical properties and anisotropic viscoelastic behavior. This study reports a novel composite poly (L-lactide) (PLLA) scaffold that is manufactured by a simple electrospinning and biomineralization technique that precisely controls the fibrous structure in liquid LC phase. The enriched-LC composites have superior mineralization ability than neat PLLA; furthermore BMSC cells were inoculated onto the HAP-PLLA/LC with hydroxyapatite (HAP) composite scaffold to test the capability for osteogenesis in vitro. The results show that the PLLA/LC with HAP produced by mineralization leads to better cell compatibility, which is beneficial to cell proliferation, osteogenic differentiation, and expression of the angiogenic CD31 gene. Moreover, in vivo studies showed that the HAP-PLLA/LC scaffold with a bone-like environment significantly accelerates new and mature lamellar bone formation by development of a microenvironment for vascularized bone regeneration. Thus, this bionic composite scaffold in an LC state combining osteogenesis with vascularized activities is a promising biomaterial for bone regeneration in defective areas.Yi ZhanBing DengHuixian WuChangpeng XuRuiying WangWenqiang LiZhixiong PanZhixiong PanFrontiers Media S.A.articleliquid crystal fiberbiomimetic mineralizationosteogenic differentiationvascularizationregenerationTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	liquid crystal fiber biomimetic mineralization osteogenic differentiation vascularization regeneration Therapeutics. Pharmacology RM1-950
spellingShingle	liquid crystal fiber biomimetic mineralization osteogenic differentiation vascularization regeneration Therapeutics. Pharmacology RM1-950 Yi Zhan Bing Deng Huixian Wu Changpeng Xu Ruiying Wang Wenqiang Li Zhixiong Pan Zhixiong Pan Biomineralized Composite Liquid Crystal Fiber Scaffold Promotes Bone Regeneration by Enhancement of Osteogenesis and Angiogenesis
description	Liquid crystals (LCs) are appealing biomaterials for applications in bone regenerative medicine due to their tunable physical properties and anisotropic viscoelastic behavior. This study reports a novel composite poly (L-lactide) (PLLA) scaffold that is manufactured by a simple electrospinning and biomineralization technique that precisely controls the fibrous structure in liquid LC phase. The enriched-LC composites have superior mineralization ability than neat PLLA; furthermore BMSC cells were inoculated onto the HAP-PLLA/LC with hydroxyapatite (HAP) composite scaffold to test the capability for osteogenesis in vitro. The results show that the PLLA/LC with HAP produced by mineralization leads to better cell compatibility, which is beneficial to cell proliferation, osteogenic differentiation, and expression of the angiogenic CD31 gene. Moreover, in vivo studies showed that the HAP-PLLA/LC scaffold with a bone-like environment significantly accelerates new and mature lamellar bone formation by development of a microenvironment for vascularized bone regeneration. Thus, this bionic composite scaffold in an LC state combining osteogenesis with vascularized activities is a promising biomaterial for bone regeneration in defective areas.
format	article
author	Yi Zhan Bing Deng Huixian Wu Changpeng Xu Ruiying Wang Wenqiang Li Zhixiong Pan Zhixiong Pan
author_facet	Yi Zhan Bing Deng Huixian Wu Changpeng Xu Ruiying Wang Wenqiang Li Zhixiong Pan Zhixiong Pan
author_sort	Yi Zhan
title	Biomineralized Composite Liquid Crystal Fiber Scaffold Promotes Bone Regeneration by Enhancement of Osteogenesis and Angiogenesis
title_short	Biomineralized Composite Liquid Crystal Fiber Scaffold Promotes Bone Regeneration by Enhancement of Osteogenesis and Angiogenesis
title_full	Biomineralized Composite Liquid Crystal Fiber Scaffold Promotes Bone Regeneration by Enhancement of Osteogenesis and Angiogenesis
title_fullStr	Biomineralized Composite Liquid Crystal Fiber Scaffold Promotes Bone Regeneration by Enhancement of Osteogenesis and Angiogenesis
title_full_unstemmed	Biomineralized Composite Liquid Crystal Fiber Scaffold Promotes Bone Regeneration by Enhancement of Osteogenesis and Angiogenesis
title_sort	biomineralized composite liquid crystal fiber scaffold promotes bone regeneration by enhancement of osteogenesis and angiogenesis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/19df11f067eb4317af9af98c6097bf4e
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_version_	1718442977613840384

Biomineralized Composite Liquid Crystal Fiber Scaffold Promotes Bone Regeneration by Enhancement of Osteogenesis and Angiogenesis

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