Homocysteine and C-reactive protein levels in women with polycystic ovary syndrome

Objectives: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in infertile women characterized by both reproductive and metabolic dysfunctions of different degrees. Furthermore, it has been associated with increased cardiovascular disease (CVD) risk and related long-term health sequ...

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Autores principales:	Murat Gözüküçük, Aslı Yarcı Gürsoy, Emre Destegül, Salih Taşkİn, Hakan Şatıroğlu
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	c-reactive protein homocysteine polycystic ovary syndrome Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/19e260343d6646d3937cfdde1af57397
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spelling	oai:doaj.org-article:19e260343d6646d3937cfdde1af573972021-11-12T10:10:38ZHomocysteine and C-reactive protein levels in women with polycystic ovary syndrome2213-307010.4103/GMIT.GMIT_30_20https://doaj.org/article/19e260343d6646d3937cfdde1af573972021-01-01T00:00:00Zhttp://www.e-gmit.com/article.asp?issn=2213-3070;year=2021;volume=10;issue=4;spage=210;epage=214;aulast=Gözüküçükhttps://doaj.org/toc/2213-3070Objectives: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in infertile women characterized by both reproductive and metabolic dysfunctions of different degrees. Furthermore, it has been associated with increased cardiovascular disease (CVD) risk and related long-term health sequela. The aim of this study is to evaluate serum homocysteine (Hcy) and C-reactive protein (CRP) levels in women with PCOS and to evaluate their relationship with clinical and laboratory parameters in women with PCOS.Materials and Methods: The prospective single-center study included 45 women with PCOS (study group) and 41 control subjects. Demographic variables and Hcy, CRP, fasting blood glucose, insulin, follicle-stimulating hormone, luteinizing hormone, estradiol, total and free testosterone, dehydroepiandrosterone sulfate, thyroid-stimulating hormone levels, and lipid profiles of the subjects were recorded. homeostatic model assessment for insulin resistance (HOMA-IR) indexes were calculated.Results: Fasting plasma glucose, insulin, HOMA-IR, free and total testosterone levels, and clinical hirsutism were significantly higher in the study group. There was no statistically significant difference in lipid profile between groups. Hcy and CRP levels were higher in the study group, which was not statistically significantly different (P > 0.05).Conclusion: Some of the parameters that are correlated with CVD risk were found to be higher in women with PCOS, although the difference for Hcy and CRP did not reach statistical significance. However, the current study reveals that the CVD risk associated with PCOS deserves more comprehensive prospective studies with long-term outcomes.Murat GözüküçükAslı Yarcı GürsoyEmre DestegülSalih TaşkİnHakan ŞatıroğluWolters Kluwer Medknow Publicationsarticlec-reactive proteinhomocysteinepolycystic ovary syndromeGynecology and obstetricsRG1-991ENGynecology and Minimally Invasive Therapy, Vol 10, Iss 4, Pp 210-214 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	c-reactive protein homocysteine polycystic ovary syndrome Gynecology and obstetrics RG1-991
spellingShingle	c-reactive protein homocysteine polycystic ovary syndrome Gynecology and obstetrics RG1-991 Murat Gözüküçük Aslı Yarcı Gürsoy Emre Destegül Salih Taşkİn Hakan Şatıroğlu Homocysteine and C-reactive protein levels in women with polycystic ovary syndrome
description	Objectives: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in infertile women characterized by both reproductive and metabolic dysfunctions of different degrees. Furthermore, it has been associated with increased cardiovascular disease (CVD) risk and related long-term health sequela. The aim of this study is to evaluate serum homocysteine (Hcy) and C-reactive protein (CRP) levels in women with PCOS and to evaluate their relationship with clinical and laboratory parameters in women with PCOS.Materials and Methods: The prospective single-center study included 45 women with PCOS (study group) and 41 control subjects. Demographic variables and Hcy, CRP, fasting blood glucose, insulin, follicle-stimulating hormone, luteinizing hormone, estradiol, total and free testosterone, dehydroepiandrosterone sulfate, thyroid-stimulating hormone levels, and lipid profiles of the subjects were recorded. homeostatic model assessment for insulin resistance (HOMA-IR) indexes were calculated.Results: Fasting plasma glucose, insulin, HOMA-IR, free and total testosterone levels, and clinical hirsutism were significantly higher in the study group. There was no statistically significant difference in lipid profile between groups. Hcy and CRP levels were higher in the study group, which was not statistically significantly different (P > 0.05).Conclusion: Some of the parameters that are correlated with CVD risk were found to be higher in women with PCOS, although the difference for Hcy and CRP did not reach statistical significance. However, the current study reveals that the CVD risk associated with PCOS deserves more comprehensive prospective studies with long-term outcomes.
format	article
author	Murat Gözüküçük Aslı Yarcı Gürsoy Emre Destegül Salih Taşkİn Hakan Şatıroğlu
author_facet	Murat Gözüküçük Aslı Yarcı Gürsoy Emre Destegül Salih Taşkİn Hakan Şatıroğlu
author_sort	Murat Gözüküçük
title	Homocysteine and C-reactive protein levels in women with polycystic ovary syndrome
title_short	Homocysteine and C-reactive protein levels in women with polycystic ovary syndrome
title_full	Homocysteine and C-reactive protein levels in women with polycystic ovary syndrome
title_fullStr	Homocysteine and C-reactive protein levels in women with polycystic ovary syndrome
title_full_unstemmed	Homocysteine and C-reactive protein levels in women with polycystic ovary syndrome
title_sort	homocysteine and c-reactive protein levels in women with polycystic ovary syndrome
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/19e260343d6646d3937cfdde1af57397
work_keys_str_mv	AT muratgozukucuk homocysteineandcreactiveproteinlevelsinwomenwithpolycysticovarysyndrome AT aslıyarcıgursoy homocysteineandcreactiveproteinlevelsinwomenwithpolycysticovarysyndrome AT emredestegul homocysteineandcreactiveproteinlevelsinwomenwithpolycysticovarysyndrome AT salihtaskin homocysteineandcreactiveproteinlevelsinwomenwithpolycysticovarysyndrome AT hakansatıroglu homocysteineandcreactiveproteinlevelsinwomenwithpolycysticovarysyndrome
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Homocysteine and C-reactive protein levels in women with polycystic ovary syndrome

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