Study on the mechanism of Renshen Gansong herb in the treatment of paroxysmal atrial fibrillation based on network pharmacology
Objective: To explore the target gene and mechanism of effective components of Renshen- Gansong in the treatment of paroxysmal atrial fibrillation based on network pharmacology. Methods: The chemical constituents of Renshen-Gansong drug pairs were searched by TCMSP traditional Chinese medicine da...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Editorial Board of Journal of Hainan Medical University
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/19e5518d555d42549685e81d1bb3a7c5 |
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| Sumario: | Objective: To explore the target gene and mechanism of effective components of Renshen-
Gansong in the treatment of paroxysmal atrial fibrillation based on network pharmacology.
Methods: The chemical constituents of Renshen-Gansong drug pairs were searched by
TCMSP traditional Chinese medicine database.The potentially effective components were
screened under the conditions of bioavailability (OB) ≥ 30% and drug-like (DL) ≥ 0.18,and
the potential targets were predicted by TCMSP database.The human gene name corresponding
to the potential target was found by Uniprot database,and the disease target of paroxysmal
atrial fibrillation was searched by Genecards database,the intersection target was mapped
with the potential target of drug pair,the Wayne diagram was drawn,and the disease-drugcomponent-
target network map was constructed by Cytoscape3.7.2.The PPI protein interaction
network map was constructed by STRING database to select the core targets,and finally GO
analysis and KEGG analysis were carried out. Results: A total of 28 active components and 45
effective targets were obtained.GO enrichment analysis showed that the main pathways were
neurotransmitter receptor activity,ion gated channel activity,passive transmembrane transporter
activity, G protein coupled neurotransmitter receptor activity and so on. KEGG pathway
enrichment analysis showed that the main pathways were IL-17 signal pathway, calcium signal
pathway,TNF signal pathway and so on. Conclusion: Renshen-Gansong has a synergistic
effect on the treatment of paroxysmal atrial fibrillation through multi-targets, multi-pathways
and multiple signal pathways, which provides a basis for further study of drug mechanism and
clinical guidance. |
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