Study on the mechanism of Renshen Gansong herb in the treatment of paroxysmal atrial fibrillation based on network pharmacology

Objective: To explore the target gene and mechanism of effective components of Renshen- Gansong in the treatment of paroxysmal atrial fibrillation based on network pharmacology. Methods: The chemical constituents of Renshen-Gansong drug pairs were searched by TCMSP traditional Chinese medicine da...

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Autores principales:	Jing-Qi Guo, Shi-Liang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Editorial Board of Journal of Hainan Medical University 2021
Materias:	network pharmacology renshen gansong paroxysmal atrial fibrillation mechanism of action Medicine R
Acceso en línea:	https://doaj.org/article/19e5518d555d42549685e81d1bb3a7c5
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spelling	oai:doaj.org-article:19e5518d555d42549685e81d1bb3a7c52021-12-01T05:18:59ZStudy on the mechanism of Renshen Gansong herb in the treatment of paroxysmal atrial fibrillation based on network pharmacology1007-1237https://doaj.org/article/19e5518d555d42549685e81d1bb3a7c52021-10-01T00:00:00Zhttp://www.hnykdxxb.com/PDF/202120/09.pdfhttps://doaj.org/toc/1007-1237Objective: To explore the target gene and mechanism of effective components of Renshen- Gansong in the treatment of paroxysmal atrial fibrillation based on network pharmacology. Methods: The chemical constituents of Renshen-Gansong drug pairs were searched by TCMSP traditional Chinese medicine database.The potentially effective components were screened under the conditions of bioavailability (OB) ≥ 30% and drug-like (DL) ≥ 0.18,and the potential targets were predicted by TCMSP database.The human gene name corresponding to the potential target was found by Uniprot database,and the disease target of paroxysmal atrial fibrillation was searched by Genecards database,the intersection target was mapped with the potential target of drug pair,the Wayne diagram was drawn,and the disease-drugcomponent- target network map was constructed by Cytoscape3.7.2.The PPI protein interaction network map was constructed by STRING database to select the core targets,and finally GO analysis and KEGG analysis were carried out. Results: A total of 28 active components and 45 effective targets were obtained.GO enrichment analysis showed that the main pathways were neurotransmitter receptor activity,ion gated channel activity,passive transmembrane transporter activity, G protein coupled neurotransmitter receptor activity and so on. KEGG pathway enrichment analysis showed that the main pathways were IL-17 signal pathway, calcium signal pathway,TNF signal pathway and so on. Conclusion: Renshen-Gansong has a synergistic effect on the treatment of paroxysmal atrial fibrillation through multi-targets, multi-pathways and multiple signal pathways, which provides a basis for further study of drug mechanism and clinical guidance.Jing-Qi GuoShi-Liang ZhangEditorial Board of Journal of Hainan Medical Universityarticlenetwork pharmacologyrenshengansongparoxysmal atrial fibrillationmechanism of actionMedicineRENJournal of Hainan Medical University, Vol 27, Iss 20, Pp 44-49 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	network pharmacology renshen gansong paroxysmal atrial fibrillation mechanism of action Medicine R
spellingShingle	network pharmacology renshen gansong paroxysmal atrial fibrillation mechanism of action Medicine R Jing-Qi Guo Shi-Liang Zhang Study on the mechanism of Renshen Gansong herb in the treatment of paroxysmal atrial fibrillation based on network pharmacology
description	Objective: To explore the target gene and mechanism of effective components of Renshen- Gansong in the treatment of paroxysmal atrial fibrillation based on network pharmacology. Methods: The chemical constituents of Renshen-Gansong drug pairs were searched by TCMSP traditional Chinese medicine database.The potentially effective components were screened under the conditions of bioavailability (OB) ≥ 30% and drug-like (DL) ≥ 0.18,and the potential targets were predicted by TCMSP database.The human gene name corresponding to the potential target was found by Uniprot database,and the disease target of paroxysmal atrial fibrillation was searched by Genecards database,the intersection target was mapped with the potential target of drug pair,the Wayne diagram was drawn,and the disease-drugcomponent- target network map was constructed by Cytoscape3.7.2.The PPI protein interaction network map was constructed by STRING database to select the core targets,and finally GO analysis and KEGG analysis were carried out. Results: A total of 28 active components and 45 effective targets were obtained.GO enrichment analysis showed that the main pathways were neurotransmitter receptor activity,ion gated channel activity,passive transmembrane transporter activity, G protein coupled neurotransmitter receptor activity and so on. KEGG pathway enrichment analysis showed that the main pathways were IL-17 signal pathway, calcium signal pathway,TNF signal pathway and so on. Conclusion: Renshen-Gansong has a synergistic effect on the treatment of paroxysmal atrial fibrillation through multi-targets, multi-pathways and multiple signal pathways, which provides a basis for further study of drug mechanism and clinical guidance.
format	article
author	Jing-Qi Guo Shi-Liang Zhang
author_facet	Jing-Qi Guo Shi-Liang Zhang
author_sort	Jing-Qi Guo
title	Study on the mechanism of Renshen Gansong herb in the treatment of paroxysmal atrial fibrillation based on network pharmacology
title_short	Study on the mechanism of Renshen Gansong herb in the treatment of paroxysmal atrial fibrillation based on network pharmacology
title_full	Study on the mechanism of Renshen Gansong herb in the treatment of paroxysmal atrial fibrillation based on network pharmacology
title_fullStr	Study on the mechanism of Renshen Gansong herb in the treatment of paroxysmal atrial fibrillation based on network pharmacology
title_full_unstemmed	Study on the mechanism of Renshen Gansong herb in the treatment of paroxysmal atrial fibrillation based on network pharmacology
title_sort	study on the mechanism of renshen gansong herb in the treatment of paroxysmal atrial fibrillation based on network pharmacology
publisher	Editorial Board of Journal of Hainan Medical University
publishDate	2021
url	https://doaj.org/article/19e5518d555d42549685e81d1bb3a7c5
work_keys_str_mv	AT jingqiguo studyonthemechanismofrenshengansongherbinthetreatmentofparoxysmalatrialfibrillationbasedonnetworkpharmacology AT shiliangzhang studyonthemechanismofrenshengansongherbinthetreatmentofparoxysmalatrialfibrillationbasedonnetworkpharmacology
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Study on the mechanism of Renshen Gansong herb in the treatment of paroxysmal atrial fibrillation based on network pharmacology

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