Kilogram synthesis of (R)-(-)-denopamine by Ir/f-amphox catalyzed asymmetric hydrogenation

A practical and efficient two-step synthetic process for the preparation of (R)-(-)-denopamine has been developed. The key step asymmetric hydrogenation was conducted at mild temperature (60 ​°C) under a hydrogen pressure of 50 ​atm by using Ir/f-amphox as catalyst at low catalyst loading (S/C ​= ​2...

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Autores principales: Yongpeng Zheng, Xumu Zhang, Runtong Zhang, Baode Ma
Formato: article
Lenguaje:EN
Publicado: KeAi Communications Co. Ltd. 2021
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Acceso en línea:https://doaj.org/article/19ed00e7bde540b28648ba550eba3ae8
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