TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells

YAP is a transcriptional co-activator downstream of Hippo pathway that displays oncogenic but also tumour suppressive functions. Here, the authors perform an unbiased genome wide CRISPR screen and identify Trichorhinophalangeal syndrome 1 (TRPS1) that represses YAP/TEAD activity independently of Hip...

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Autores principales:	Dana Elster, Marie Tollot, Karin Schlegelmilch, Alessandro Ori, Andreas Rosenwald, Erik Sahai, Björn von Eyss
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/19eda7757ab247bd9fb586db28f84dc9
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spelling	oai:doaj.org-article:19eda7757ab247bd9fb586db28f84dc92021-12-02T17:31:30ZTRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells10.1038/s41467-018-05370-72041-1723https://doaj.org/article/19eda7757ab247bd9fb586db28f84dc92018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05370-7https://doaj.org/toc/2041-1723YAP is a transcriptional co-activator downstream of Hippo pathway that displays oncogenic but also tumour suppressive functions. Here, the authors perform an unbiased genome wide CRISPR screen and identify Trichorhinophalangeal syndrome 1 (TRPS1) that represses YAP/TEAD activity independently of Hippo pathway in breast cancer.Dana ElsterMarie TollotKarin SchlegelmilchAlessandro OriAndreas RosenwaldErik SahaiBjörn von EyssNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dana Elster Marie Tollot Karin Schlegelmilch Alessandro Ori Andreas Rosenwald Erik Sahai Björn von Eyss TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells
description	YAP is a transcriptional co-activator downstream of Hippo pathway that displays oncogenic but also tumour suppressive functions. Here, the authors perform an unbiased genome wide CRISPR screen and identify Trichorhinophalangeal syndrome 1 (TRPS1) that represses YAP/TEAD activity independently of Hippo pathway in breast cancer.
format	article
author	Dana Elster Marie Tollot Karin Schlegelmilch Alessandro Ori Andreas Rosenwald Erik Sahai Björn von Eyss
author_facet	Dana Elster Marie Tollot Karin Schlegelmilch Alessandro Ori Andreas Rosenwald Erik Sahai Björn von Eyss
author_sort	Dana Elster
title	TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells
title_short	TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells
title_full	TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells
title_fullStr	TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells
title_full_unstemmed	TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells
title_sort	trps1 shapes yap/tead-dependent transcription in breast cancer cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/19eda7757ab247bd9fb586db28f84dc9
work_keys_str_mv	AT danaelster trps1shapesyapteaddependenttranscriptioninbreastcancercells AT marietollot trps1shapesyapteaddependenttranscriptioninbreastcancercells AT karinschlegelmilch trps1shapesyapteaddependenttranscriptioninbreastcancercells AT alessandroori trps1shapesyapteaddependenttranscriptioninbreastcancercells AT andreasrosenwald trps1shapesyapteaddependenttranscriptioninbreastcancercells AT eriksahai trps1shapesyapteaddependenttranscriptioninbreastcancercells AT bjornvoneyss trps1shapesyapteaddependenttranscriptioninbreastcancercells
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TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells

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