Cerebrospinal fluid markers in incident pediatric-onset multiple sclerosis: a nationwide study

Abstract To investigate whether cerebrospinal fluid (CSF) markers differ between pediatric-onset multiple sclerosis (PoMS, onset < 18 years) and adult-onset (AoMS), and whether these markers are associated with clinical outcomes among PoMS. Prospective nationwide registry study of incident MS, in...

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Autores principales:	Kyla A. McKay, Ronny Wickström, Jan Hillert, Virginija Danylaite Karrenbauer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/19ee7f7483874f38ac49d944e5ce2b46
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spelling	oai:doaj.org-article:19ee7f7483874f38ac49d944e5ce2b462021-12-02T15:31:36ZCerebrospinal fluid markers in incident pediatric-onset multiple sclerosis: a nationwide study10.1038/s41598-021-97543-62045-2322https://doaj.org/article/19ee7f7483874f38ac49d944e5ce2b462021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97543-6https://doaj.org/toc/2045-2322Abstract To investigate whether cerebrospinal fluid (CSF) markers differ between pediatric-onset multiple sclerosis (PoMS, onset < 18 years) and adult-onset (AoMS), and whether these markers are associated with clinical outcomes among PoMS. Prospective nationwide registry study of incident MS, including persons with a CSF sample < 3 years post-MS onset. We compared CSF oligoclonal band (OCB) status, immunoglobulin G (IgG) index levels, and mononuclear cell count between PoMS and AoMS. Within the PoMS cohort we analyzed the association between CSF markers, relapse rate and Expanded Disability Status Scale (EDSS) score, using negative binomial regression and generalized estimating equations, respectively. The cohort consisted of 130 PoMS and 3228 AoMS cases. The PoMS group had higher odds of OCB-positivity (odds ratio: 2.70; 95% CI 1.21–7.67). None of the CSF markers were associated with relapse rate in the PoMS cohort; however, OCB-positivity was associated with higher EDSS scores. This study suggested that PoMS more commonly display CSF evidence for intrathecal IgG production than AoMS. Further, we found evidence of a relationship between OCB-positivity and subsequent disability, suggesting that they could play a role in the prognostication of MS in children.Kyla A. McKayRonny WickströmJan HillertVirginija Danylaite KarrenbauerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kyla A. McKay Ronny Wickström Jan Hillert Virginija Danylaite Karrenbauer Cerebrospinal fluid markers in incident pediatric-onset multiple sclerosis: a nationwide study
description	Abstract To investigate whether cerebrospinal fluid (CSF) markers differ between pediatric-onset multiple sclerosis (PoMS, onset < 18 years) and adult-onset (AoMS), and whether these markers are associated with clinical outcomes among PoMS. Prospective nationwide registry study of incident MS, including persons with a CSF sample < 3 years post-MS onset. We compared CSF oligoclonal band (OCB) status, immunoglobulin G (IgG) index levels, and mononuclear cell count between PoMS and AoMS. Within the PoMS cohort we analyzed the association between CSF markers, relapse rate and Expanded Disability Status Scale (EDSS) score, using negative binomial regression and generalized estimating equations, respectively. The cohort consisted of 130 PoMS and 3228 AoMS cases. The PoMS group had higher odds of OCB-positivity (odds ratio: 2.70; 95% CI 1.21–7.67). None of the CSF markers were associated with relapse rate in the PoMS cohort; however, OCB-positivity was associated with higher EDSS scores. This study suggested that PoMS more commonly display CSF evidence for intrathecal IgG production than AoMS. Further, we found evidence of a relationship between OCB-positivity and subsequent disability, suggesting that they could play a role in the prognostication of MS in children.
format	article
author	Kyla A. McKay Ronny Wickström Jan Hillert Virginija Danylaite Karrenbauer
author_facet	Kyla A. McKay Ronny Wickström Jan Hillert Virginija Danylaite Karrenbauer
author_sort	Kyla A. McKay
title	Cerebrospinal fluid markers in incident pediatric-onset multiple sclerosis: a nationwide study
title_short	Cerebrospinal fluid markers in incident pediatric-onset multiple sclerosis: a nationwide study
title_full	Cerebrospinal fluid markers in incident pediatric-onset multiple sclerosis: a nationwide study
title_fullStr	Cerebrospinal fluid markers in incident pediatric-onset multiple sclerosis: a nationwide study
title_full_unstemmed	Cerebrospinal fluid markers in incident pediatric-onset multiple sclerosis: a nationwide study
title_sort	cerebrospinal fluid markers in incident pediatric-onset multiple sclerosis: a nationwide study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/19ee7f7483874f38ac49d944e5ce2b46
work_keys_str_mv	AT kylaamckay cerebrospinalfluidmarkersinincidentpediatriconsetmultiplesclerosisanationwidestudy AT ronnywickstrom cerebrospinalfluidmarkersinincidentpediatriconsetmultiplesclerosisanationwidestudy AT janhillert cerebrospinalfluidmarkersinincidentpediatriconsetmultiplesclerosisanationwidestudy AT virginijadanylaitekarrenbauer cerebrospinalfluidmarkersinincidentpediatriconsetmultiplesclerosisanationwidestudy
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Cerebrospinal fluid markers in incident pediatric-onset multiple sclerosis: a nationwide study

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