Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival

The lipogenic pathway is often upregulated in liver tumours and regarded as a therapeutic target. Here, the authors show instead that blocking lipogenesis via knockout of acetyl-CoA carboxylase genes results in increased susceptibility to liver tumorigenesis associated with an increased antioxidant...

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Autores principales:	Marin E. Nelson, Sujoy Lahiri, Jenny D. Y. Chow, Frances L. Byrne, Stefan R. Hargett, David S. Breen, Ellen M. Olzomer, Lindsay E. Wu, Gregory J. Cooney, Nigel Turner, David E. James, Jill K. Slack-Davis, Carolin Lackner, Stephen H. Caldwell, Kyle L. Hoehn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/19ef0685f5d74b788afe67c6f9e96489
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spelling	oai:doaj.org-article:19ef0685f5d74b788afe67c6f9e964892021-12-02T14:41:18ZInhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival10.1038/ncomms146892041-1723https://doaj.org/article/19ef0685f5d74b788afe67c6f9e964892017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14689https://doaj.org/toc/2041-1723The lipogenic pathway is often upregulated in liver tumours and regarded as a therapeutic target. Here, the authors show instead that blocking lipogenesis via knockout of acetyl-CoA carboxylase genes results in increased susceptibility to liver tumorigenesis associated with an increased antioxidant defence.Marin E. NelsonSujoy LahiriJenny D. Y. ChowFrances L. ByrneStefan R. HargettDavid S. BreenEllen M. OlzomerLindsay E. WuGregory J. CooneyNigel TurnerDavid E. JamesJill K. Slack-DavisCarolin LacknerStephen H. CaldwellKyle L. HoehnNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marin E. Nelson Sujoy Lahiri Jenny D. Y. Chow Frances L. Byrne Stefan R. Hargett David S. Breen Ellen M. Olzomer Lindsay E. Wu Gregory J. Cooney Nigel Turner David E. James Jill K. Slack-Davis Carolin Lackner Stephen H. Caldwell Kyle L. Hoehn Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival
description	The lipogenic pathway is often upregulated in liver tumours and regarded as a therapeutic target. Here, the authors show instead that blocking lipogenesis via knockout of acetyl-CoA carboxylase genes results in increased susceptibility to liver tumorigenesis associated with an increased antioxidant defence.
format	article
author	Marin E. Nelson Sujoy Lahiri Jenny D. Y. Chow Frances L. Byrne Stefan R. Hargett David S. Breen Ellen M. Olzomer Lindsay E. Wu Gregory J. Cooney Nigel Turner David E. James Jill K. Slack-Davis Carolin Lackner Stephen H. Caldwell Kyle L. Hoehn
author_facet	Marin E. Nelson Sujoy Lahiri Jenny D. Y. Chow Frances L. Byrne Stefan R. Hargett David S. Breen Ellen M. Olzomer Lindsay E. Wu Gregory J. Cooney Nigel Turner David E. James Jill K. Slack-Davis Carolin Lackner Stephen H. Caldwell Kyle L. Hoehn
author_sort	Marin E. Nelson
title	Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival
title_short	Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival
title_full	Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival
title_fullStr	Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival
title_full_unstemmed	Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival
title_sort	inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/19ef0685f5d74b788afe67c6f9e96489
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Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival

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