Monitoring the haemodynamic response to visual stimulation in glaucoma patients

Abstract In this paper, we used time-domain functional near infrared spectroscopy (TD-fNIRS) to evaluate the haemodynamic response function (HRF) in the occipital cortex following visual stimulation in glaucomatous eyes as compared to healthy eyes. A total of 98 subjects were enrolled in the study a...

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Autores principales:	R. Re, D. Messenio, G. Marano, L. Spinelli, I. Pirovano, D. Contini, R. Colombo, P. Boracchi, E. Biganzoli, R. Cubeddu, A. Torricelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/19f10bc608c04b3d8dc9d4a6a40cd894
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spelling	oai:doaj.org-article:19f10bc608c04b3d8dc9d4a6a40cd8942021-12-02T18:18:58ZMonitoring the haemodynamic response to visual stimulation in glaucoma patients10.1038/s41598-021-92857-x2045-2322https://doaj.org/article/19f10bc608c04b3d8dc9d4a6a40cd8942021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92857-xhttps://doaj.org/toc/2045-2322Abstract In this paper, we used time-domain functional near infrared spectroscopy (TD-fNIRS) to evaluate the haemodynamic response function (HRF) in the occipital cortex following visual stimulation in glaucomatous eyes as compared to healthy eyes. A total of 98 subjects were enrolled in the study and clinically classified as healthy subjects, glaucoma patients (primary open-angle glaucoma) and mixed subjects (i.e. with a different classification for the two eyes). After quality check data were used from HRF of 73 healthy and 62 glaucomatous eyes. The amplitudes of the oxygenated and deoxygenated haemoglobin concentrations, together with their latencies with respect to the stimulus onset, were estimated by fitting their time course with a canonical HRF. Statistical analysis showed that the amplitudes of both haemodynamic parameters show a significant association with the pathology and a significant discriminating ability, while no significant result was found for latencies. Overall, our findings together with the ease of use and noninvasiveness of TD-NIRS, make this technique a promising candidate as a supporting tool for a better evaluation of the glaucoma pathology.R. ReD. MessenioG. MaranoL. SpinelliI. PirovanoD. ContiniR. ColomboP. BoracchiE. BiganzoliR. CubedduA. TorricelliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q R. Re D. Messenio G. Marano L. Spinelli I. Pirovano D. Contini R. Colombo P. Boracchi E. Biganzoli R. Cubeddu A. Torricelli Monitoring the haemodynamic response to visual stimulation in glaucoma patients
description	Abstract In this paper, we used time-domain functional near infrared spectroscopy (TD-fNIRS) to evaluate the haemodynamic response function (HRF) in the occipital cortex following visual stimulation in glaucomatous eyes as compared to healthy eyes. A total of 98 subjects were enrolled in the study and clinically classified as healthy subjects, glaucoma patients (primary open-angle glaucoma) and mixed subjects (i.e. with a different classification for the two eyes). After quality check data were used from HRF of 73 healthy and 62 glaucomatous eyes. The amplitudes of the oxygenated and deoxygenated haemoglobin concentrations, together with their latencies with respect to the stimulus onset, were estimated by fitting their time course with a canonical HRF. Statistical analysis showed that the amplitudes of both haemodynamic parameters show a significant association with the pathology and a significant discriminating ability, while no significant result was found for latencies. Overall, our findings together with the ease of use and noninvasiveness of TD-NIRS, make this technique a promising candidate as a supporting tool for a better evaluation of the glaucoma pathology.
format	article
author	R. Re D. Messenio G. Marano L. Spinelli I. Pirovano D. Contini R. Colombo P. Boracchi E. Biganzoli R. Cubeddu A. Torricelli
author_facet	R. Re D. Messenio G. Marano L. Spinelli I. Pirovano D. Contini R. Colombo P. Boracchi E. Biganzoli R. Cubeddu A. Torricelli
author_sort	R. Re
title	Monitoring the haemodynamic response to visual stimulation in glaucoma patients
title_short	Monitoring the haemodynamic response to visual stimulation in glaucoma patients
title_full	Monitoring the haemodynamic response to visual stimulation in glaucoma patients
title_fullStr	Monitoring the haemodynamic response to visual stimulation in glaucoma patients
title_full_unstemmed	Monitoring the haemodynamic response to visual stimulation in glaucoma patients
title_sort	monitoring the haemodynamic response to visual stimulation in glaucoma patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/19f10bc608c04b3d8dc9d4a6a40cd894
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Monitoring the haemodynamic response to visual stimulation in glaucoma patients

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