The Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients

Background: Patients on dialysis have impaired cardiac function, in part due to increased fluid volume and ventricular stress. Restored kidney function through transplantation reduces left ventricular volume in both systole and diastole. We previously reported that the decrease in NT-proB-type natri...

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Autores principales:	Philip W. Connelly, Andrew T. Yan, Michelle M. Nash, Rachel M. Wald, Charmaine Lok, Lakshman Gunaratnam, Anish Kirpalani, G. V. Ramesh Prasad
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	paraoxonase 1 kidney transplantation left ventricular hypertrophy cardiac magnetic resonance imaging dialysis Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/19f130a6c6e8491b8e58c2178de8ef7f
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spelling	oai:doaj.org-article:19f130a6c6e8491b8e58c2178de8ef7f2021-12-02T09:12:12ZThe Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients2297-055X10.3389/fcvm.2021.763389https://doaj.org/article/19f130a6c6e8491b8e58c2178de8ef7f2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.763389/fullhttps://doaj.org/toc/2297-055XBackground: Patients on dialysis have impaired cardiac function, in part due to increased fluid volume and ventricular stress. Restored kidney function through transplantation reduces left ventricular volume in both systole and diastole. We previously reported that the decrease in NT-proB-type natriuretic peptide (NT-proBNP) was associated with a decrease in adiponectin. Paraoxonase 1 (PON1) has been inversely associated with cardiovascular outcomes. We now report the association of changes in PON1 with changes in left ventricular volume and left ventricular mass after kidney transplantation.Design: Patients on dialysis were assessed at baseline and 12 months after kidney transplantation (n = 38). A comparison group of patients on dialysis who were not expected to receive a transplant in the next 24 months were studied (n = 43) to determine if the change of PON1 with kidney transplantation achieved a significance greater than that due to biologic variation. Left ventricular volume and mass were determined by cardiac magnetic resonance imaging. PON1 was measured by arylesterase activity and by mass.Results: PON1 mass and activity were not different between the groups at baseline. Both PON1 mass and activity were increased post-kidney transplantation (p < 0.0001 for change). The change in PON1 mass (p = 0.0062) and PON1 arylesterase activity (p = 0.0254) were inversely correlated with the change in NT-proBNP for patients receiving a kidney transplant. However, only the change in the PON1 mass, and not the change in PON1 arylesterase, was inversely correlated with the change in left ventricular volume (ml/m2.7) (p = 0.0146 and 0.0114 for diastolic and systolic, respectively) and with the change in hemoglobin (p = 0.0042).Conclusion: Both PON1 mass and arylesterase activity are increased by kidney transplantation. The increase in PON1 mass is consistent with a novel relationship to the increase in hemoglobin and decrease in left ventricular volume and NT-proBNP seen when kidney function is restored.Philip W. ConnellyPhilip W. ConnellyPhilip W. ConnellyAndrew T. YanMichelle M. NashRachel M. WaldCharmaine LokLakshman GunaratnamAnish KirpalaniG. V. Ramesh PrasadFrontiers Media S.A.articleparaoxonase 1kidney transplantationleft ventricular hypertrophycardiac magnetic resonance imagingdialysisDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	paraoxonase 1 kidney transplantation left ventricular hypertrophy cardiac magnetic resonance imaging dialysis Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	paraoxonase 1 kidney transplantation left ventricular hypertrophy cardiac magnetic resonance imaging dialysis Diseases of the circulatory (Cardiovascular) system RC666-701 Philip W. Connelly Philip W. Connelly Philip W. Connelly Andrew T. Yan Michelle M. Nash Rachel M. Wald Charmaine Lok Lakshman Gunaratnam Anish Kirpalani G. V. Ramesh Prasad The Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients
description	Background: Patients on dialysis have impaired cardiac function, in part due to increased fluid volume and ventricular stress. Restored kidney function through transplantation reduces left ventricular volume in both systole and diastole. We previously reported that the decrease in NT-proB-type natriuretic peptide (NT-proBNP) was associated with a decrease in adiponectin. Paraoxonase 1 (PON1) has been inversely associated with cardiovascular outcomes. We now report the association of changes in PON1 with changes in left ventricular volume and left ventricular mass after kidney transplantation.Design: Patients on dialysis were assessed at baseline and 12 months after kidney transplantation (n = 38). A comparison group of patients on dialysis who were not expected to receive a transplant in the next 24 months were studied (n = 43) to determine if the change of PON1 with kidney transplantation achieved a significance greater than that due to biologic variation. Left ventricular volume and mass were determined by cardiac magnetic resonance imaging. PON1 was measured by arylesterase activity and by mass.Results: PON1 mass and activity were not different between the groups at baseline. Both PON1 mass and activity were increased post-kidney transplantation (p < 0.0001 for change). The change in PON1 mass (p = 0.0062) and PON1 arylesterase activity (p = 0.0254) were inversely correlated with the change in NT-proBNP for patients receiving a kidney transplant. However, only the change in the PON1 mass, and not the change in PON1 arylesterase, was inversely correlated with the change in left ventricular volume (ml/m2.7) (p = 0.0146 and 0.0114 for diastolic and systolic, respectively) and with the change in hemoglobin (p = 0.0042).Conclusion: Both PON1 mass and arylesterase activity are increased by kidney transplantation. The increase in PON1 mass is consistent with a novel relationship to the increase in hemoglobin and decrease in left ventricular volume and NT-proBNP seen when kidney function is restored.
format	article
author	Philip W. Connelly Philip W. Connelly Philip W. Connelly Andrew T. Yan Michelle M. Nash Rachel M. Wald Charmaine Lok Lakshman Gunaratnam Anish Kirpalani G. V. Ramesh Prasad
author_facet	Philip W. Connelly Philip W. Connelly Philip W. Connelly Andrew T. Yan Michelle M. Nash Rachel M. Wald Charmaine Lok Lakshman Gunaratnam Anish Kirpalani G. V. Ramesh Prasad
author_sort	Philip W. Connelly
title	The Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients
title_short	The Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients
title_full	The Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients
title_fullStr	The Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients
title_full_unstemmed	The Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients
title_sort	increase in paraoxonase 1 is associated with decrease in left ventricular volume in kidney transplant recipients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/19f130a6c6e8491b8e58c2178de8ef7f
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The Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients

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