An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis

Victoria Furió et al. apply functional genomics and evolutionary analyses to the study of antibiotic resistance in tuberculosis. Focusing on isoniazid resistance and using genomic data from clinical strains, they identify novel candidate genes with resistance mutations and further uncover the mechan...

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Autores principales:	Victoria Furió, Miguel Moreno-Molina, Álvaro Chiner-Oms, Luis M. Villamayor, Manuela Torres-Puente, Iñaki Comas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/19f431d7b8e34a2ebb1131dafa6b61b8
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spelling	oai:doaj.org-article:19f431d7b8e34a2ebb1131dafa6b61b82021-11-28T12:10:30ZAn evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis10.1038/s42003-021-02846-z2399-3642https://doaj.org/article/19f431d7b8e34a2ebb1131dafa6b61b82021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02846-zhttps://doaj.org/toc/2399-3642Victoria Furió et al. apply functional genomics and evolutionary analyses to the study of antibiotic resistance in tuberculosis. Focusing on isoniazid resistance and using genomic data from clinical strains, they identify novel candidate genes with resistance mutations and further uncover the mechanisms underlying drug resistance.Victoria FurióMiguel Moreno-MolinaÁlvaro Chiner-OmsLuis M. VillamayorManuela Torres-PuenteIñaki ComasNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Victoria Furió Miguel Moreno-Molina Álvaro Chiner-Oms Luis M. Villamayor Manuela Torres-Puente Iñaki Comas An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis
description	Victoria Furió et al. apply functional genomics and evolutionary analyses to the study of antibiotic resistance in tuberculosis. Focusing on isoniazid resistance and using genomic data from clinical strains, they identify novel candidate genes with resistance mutations and further uncover the mechanisms underlying drug resistance.
format	article
author	Victoria Furió Miguel Moreno-Molina Álvaro Chiner-Oms Luis M. Villamayor Manuela Torres-Puente Iñaki Comas
author_facet	Victoria Furió Miguel Moreno-Molina Álvaro Chiner-Oms Luis M. Villamayor Manuela Torres-Puente Iñaki Comas
author_sort	Victoria Furió
title	An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis
title_short	An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis
title_full	An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis
title_fullStr	An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis
title_full_unstemmed	An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis
title_sort	evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in mycobacterium tuberculosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/19f431d7b8e34a2ebb1131dafa6b61b8
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An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis

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