Quantitative estimation of renal function with dynamic contrast-enhanced MRI using a modified two-compartment model.

<h4>Objective</h4>To establish a simple two-compartment model for glomerular filtration rate (GFR) and renal plasma flow (RPF) estimations by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).<h4>Materials and methods</h4>A total of eight New Zealand white rabbit...

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Autores principales:	Bin Chen, Yudong Zhang, Xiaojian Song, Xiaoying Wang, Jue Zhang, Jing Fang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/19fc2bd2351a4fd684ec23afa77d9d92
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spelling	oai:doaj.org-article:19fc2bd2351a4fd684ec23afa77d9d922021-11-25T06:03:53ZQuantitative estimation of renal function with dynamic contrast-enhanced MRI using a modified two-compartment model.1932-620310.1371/journal.pone.0105087https://doaj.org/article/19fc2bd2351a4fd684ec23afa77d9d922014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25141138/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To establish a simple two-compartment model for glomerular filtration rate (GFR) and renal plasma flow (RPF) estimations by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).<h4>Materials and methods</h4>A total of eight New Zealand white rabbits were included in DCE-MRI. The two-compartment model was modified with the impulse residue function in this study. First, the reliability of GFR measurement of the proposed model was compared with other published models in Monte Carlo simulation at different noise levels. Then, functional parameters were estimated in six healthy rabbits to test the feasibility of the new model. Moreover, in order to investigate its validity of GFR estimation, two rabbits underwent acute ischemia surgical procedure in unilateral kidney before DCE-MRI, and pixel-wise measurements were implemented to detect the cortical GFR alterations between normal and abnormal kidneys.<h4>Results</h4>The lowest variability of GFR and RPF measurements were found in the proposed model in the comparison. Mean GFR was 3.03±1.1 ml/min and mean RPF was 2.64±0.5 ml/g/min in normal animals, which were in good agreement with the published values. Moreover, large GFR decline was found in dysfunction kidneys comparing to the contralateral control group.<h4>Conclusion</h4>Results in our study demonstrate that measurement of renal kinetic parameters based on the proposed model is feasible and it has the ability to discriminate GFR changes in healthy and diseased kidneys.Bin ChenYudong ZhangXiaojian SongXiaoying WangJue ZhangJing FangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e105087 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bin Chen Yudong Zhang Xiaojian Song Xiaoying Wang Jue Zhang Jing Fang Quantitative estimation of renal function with dynamic contrast-enhanced MRI using a modified two-compartment model.
description	<h4>Objective</h4>To establish a simple two-compartment model for glomerular filtration rate (GFR) and renal plasma flow (RPF) estimations by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).<h4>Materials and methods</h4>A total of eight New Zealand white rabbits were included in DCE-MRI. The two-compartment model was modified with the impulse residue function in this study. First, the reliability of GFR measurement of the proposed model was compared with other published models in Monte Carlo simulation at different noise levels. Then, functional parameters were estimated in six healthy rabbits to test the feasibility of the new model. Moreover, in order to investigate its validity of GFR estimation, two rabbits underwent acute ischemia surgical procedure in unilateral kidney before DCE-MRI, and pixel-wise measurements were implemented to detect the cortical GFR alterations between normal and abnormal kidneys.<h4>Results</h4>The lowest variability of GFR and RPF measurements were found in the proposed model in the comparison. Mean GFR was 3.03±1.1 ml/min and mean RPF was 2.64±0.5 ml/g/min in normal animals, which were in good agreement with the published values. Moreover, large GFR decline was found in dysfunction kidneys comparing to the contralateral control group.<h4>Conclusion</h4>Results in our study demonstrate that measurement of renal kinetic parameters based on the proposed model is feasible and it has the ability to discriminate GFR changes in healthy and diseased kidneys.
format	article
author	Bin Chen Yudong Zhang Xiaojian Song Xiaoying Wang Jue Zhang Jing Fang
author_facet	Bin Chen Yudong Zhang Xiaojian Song Xiaoying Wang Jue Zhang Jing Fang
author_sort	Bin Chen
title	Quantitative estimation of renal function with dynamic contrast-enhanced MRI using a modified two-compartment model.
title_short	Quantitative estimation of renal function with dynamic contrast-enhanced MRI using a modified two-compartment model.
title_full	Quantitative estimation of renal function with dynamic contrast-enhanced MRI using a modified two-compartment model.
title_fullStr	Quantitative estimation of renal function with dynamic contrast-enhanced MRI using a modified two-compartment model.
title_full_unstemmed	Quantitative estimation of renal function with dynamic contrast-enhanced MRI using a modified two-compartment model.
title_sort	quantitative estimation of renal function with dynamic contrast-enhanced mri using a modified two-compartment model.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/19fc2bd2351a4fd684ec23afa77d9d92
work_keys_str_mv	AT binchen quantitativeestimationofrenalfunctionwithdynamiccontrastenhancedmriusingamodifiedtwocompartmentmodel AT yudongzhang quantitativeestimationofrenalfunctionwithdynamiccontrastenhancedmriusingamodifiedtwocompartmentmodel AT xiaojiansong quantitativeestimationofrenalfunctionwithdynamiccontrastenhancedmriusingamodifiedtwocompartmentmodel AT xiaoyingwang quantitativeestimationofrenalfunctionwithdynamiccontrastenhancedmriusingamodifiedtwocompartmentmodel AT juezhang quantitativeestimationofrenalfunctionwithdynamiccontrastenhancedmriusingamodifiedtwocompartmentmodel AT jingfang quantitativeestimationofrenalfunctionwithdynamiccontrastenhancedmriusingamodifiedtwocompartmentmodel
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Quantitative estimation of renal function with dynamic contrast-enhanced MRI using a modified two-compartment model.

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