MDA-7/IL-24 induces Bcl-2 denitrosylation and ubiquitin-degradation involved in cancer cell apoptosis.

MDA-7/IL-24 was involved in the specific cancer apoptosis through suppression of Bcl-2 expression, which is a key apoptosis regulatory protein of the mitochondrial death pathway. However, the underlying mechanisms of this regulation are unclear. We report here that tumor-selective replicating adenov...

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Autores principales: Hui Tian, Jing Wang, BaoFu Zhang, JieHui Di, FeiFei Chen, HuiZhong Li, LianTao Li, DongSheng Pei, JunNian Zheng
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/19fc63c30d844316a0807fa0ca443d7a
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