Comparative multi-omics analyses reveal differential expression of key genes relevant for parasitism between non-encapsulated and encapsulated Trichinella
Xiaolei Liu, Yayan Feng, et al. report an annotated draft reference genome of the non-encapsulated Trichinella pseudospiralis, and perform comparative multi-omics analyses with encapsulated T. spiralis. Overexpression of TP12446, a key excretory/secretory gene, in a mouse C2C12 skeletal muscle cell...
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Nature Portfolio
2021
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oai:doaj.org-article:1a00f91bb2c945ebabc95b7155a0cc502021-12-02T13:24:17ZComparative multi-omics analyses reveal differential expression of key genes relevant for parasitism between non-encapsulated and encapsulated Trichinella10.1038/s42003-021-01650-z2399-3642https://doaj.org/article/1a00f91bb2c945ebabc95b7155a0cc502021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01650-zhttps://doaj.org/toc/2399-3642Xiaolei Liu, Yayan Feng, et al. report an annotated draft reference genome of the non-encapsulated Trichinella pseudospiralis, and perform comparative multi-omics analyses with encapsulated T. spiralis. Overexpression of TP12446, a key excretory/secretory gene, in a mouse C2C12 skeletal muscle cell line could induce inhibition of myotube formation and differentiation. These results provide insight into the mechanism of nurse cell formation and immunoevasion, as well as the identification of potential pharmacological and diagnostic targets for trichinellosis.Xiaolei LiuYayan FengXue BaiXuelin WangRui QinBin TangXinxin YuYong YangMingyuan LiuFei GaoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021) |
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Biology (General) QH301-705.5 |
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Biology (General) QH301-705.5 Xiaolei Liu Yayan Feng Xue Bai Xuelin Wang Rui Qin Bin Tang Xinxin Yu Yong Yang Mingyuan Liu Fei Gao Comparative multi-omics analyses reveal differential expression of key genes relevant for parasitism between non-encapsulated and encapsulated Trichinella |
| description |
Xiaolei Liu, Yayan Feng, et al. report an annotated draft reference genome of the non-encapsulated Trichinella pseudospiralis, and perform comparative multi-omics analyses with encapsulated T. spiralis. Overexpression of TP12446, a key excretory/secretory gene, in a mouse C2C12 skeletal muscle cell line could induce inhibition of myotube formation and differentiation. These results provide insight into the mechanism of nurse cell formation and immunoevasion, as well as the identification of potential pharmacological and diagnostic targets for trichinellosis. |
| format |
article |
| author |
Xiaolei Liu Yayan Feng Xue Bai Xuelin Wang Rui Qin Bin Tang Xinxin Yu Yong Yang Mingyuan Liu Fei Gao |
| author_facet |
Xiaolei Liu Yayan Feng Xue Bai Xuelin Wang Rui Qin Bin Tang Xinxin Yu Yong Yang Mingyuan Liu Fei Gao |
| author_sort |
Xiaolei Liu |
| title |
Comparative multi-omics analyses reveal differential expression of key genes relevant for parasitism between non-encapsulated and encapsulated Trichinella |
| title_short |
Comparative multi-omics analyses reveal differential expression of key genes relevant for parasitism between non-encapsulated and encapsulated Trichinella |
| title_full |
Comparative multi-omics analyses reveal differential expression of key genes relevant for parasitism between non-encapsulated and encapsulated Trichinella |
| title_fullStr |
Comparative multi-omics analyses reveal differential expression of key genes relevant for parasitism between non-encapsulated and encapsulated Trichinella |
| title_full_unstemmed |
Comparative multi-omics analyses reveal differential expression of key genes relevant for parasitism between non-encapsulated and encapsulated Trichinella |
| title_sort |
comparative multi-omics analyses reveal differential expression of key genes relevant for parasitism between non-encapsulated and encapsulated trichinella |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1a00f91bb2c945ebabc95b7155a0cc50 |
| work_keys_str_mv |
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| _version_ |
1718393078927065088 |