Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort
Introduction: This study aims to assess the changes in cardiovascular remodeling attributable to bodyweight gain in a middle-aged abdominal obesity cohort. A remodeling worsening might explain the increase in cardiovascular risk associated with a dynamic of weight gain.Methods: Seventy-five middle-a...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:1a0862e962fd42bfbb5e729d0be1ac2c2021-11-05T10:05:07ZArterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort2297-055X10.3389/fcvm.2021.771022https://doaj.org/article/1a0862e962fd42bfbb5e729d0be1ac2c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.771022/fullhttps://doaj.org/toc/2297-055XIntroduction: This study aims to assess the changes in cardiovascular remodeling attributable to bodyweight gain in a middle-aged abdominal obesity cohort. A remodeling worsening might explain the increase in cardiovascular risk associated with a dynamic of weight gain.Methods: Seventy-five middle-aged subjects (56 ± 5 years, 38 women) with abdominal obesity and no known cardiovascular disease underwent MRI-based examinations at baseline and at a 6.1 ± 1.2-year follow-up to monitor cardiovascular remodeling and hemodynamic variables, most notably the effective arterial elastance (Ea). Ea is a proxy of the arterial load that must be overcome during left ventricular (LV) ejection, with increased EA resulting in concentric LV remodeling.Results: Sixteen obese subjects had significant weight gain (>7%) during follow-up (WG+), whereas the 59 other individuals did not (WG–). WG+ and WG– exhibited significant differences in the baseline to follow-up evolutions of several hemodynamic parameters, notably diastolic and mean blood pressures (for mean blood pressure, WG+: +9.3 ± 10.9 mmHg vs. WG–: +1.7 ± 11.8 mmHg, p = 0.022), heart rate (WG+: +0.6 ± 9.4 min−1 vs. −8.9 ± 11.5 min−1, p = 0.003), LV concentric remodeling index (WG: +0.08 ± 0.16 g.mL−1 vs. WG−: −0.02 ± 0.13 g.mL−1, p = 0.018) and Ea (WG+: +0.20 ± 0.28 mL mmHg−1 vs. WG−: +0.01 ± 0.30 mL mmHg−1, p = 0.021). The evolution of the LV concentric remodeling index and Ea were also strongly correlated in the overall obese population (p < 0.001, R2 = 0.31).Conclusions: A weight gain dynamic is accompanied by increases in arterial load and load-related concentric LV remodeling in an isolated abdominal obesity cohort. This remodeling could have a significant impact on cardiovascular risk.Damien MandryDamien MandryNicolas GirerdNicolas GirerdNicolas GirerdZohra LamiralOlivier HuttinOlivier HuttinLaura FilippettiEmilien MicardMarie-Paule Bernadette Ncho MottohPhilip BöhmeDenis ChemlaDenis ChemlaFaïez ZannadFaïez ZannadFaïez ZannadPatrick RossignolPatrick RossignolPatrick RossignolPierre-Yves MariePierre-Yves MarieFrontiers Media S.A.articleobesityweight gainarterial loadcardiac remodelingMRIDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021) |
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obesity weight gain arterial load cardiac remodeling MRI Diseases of the circulatory (Cardiovascular) system RC666-701 |
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obesity weight gain arterial load cardiac remodeling MRI Diseases of the circulatory (Cardiovascular) system RC666-701 Damien Mandry Damien Mandry Nicolas Girerd Nicolas Girerd Nicolas Girerd Zohra Lamiral Olivier Huttin Olivier Huttin Laura Filippetti Emilien Micard Marie-Paule Bernadette Ncho Mottoh Philip Böhme Denis Chemla Denis Chemla Faïez Zannad Faïez Zannad Faïez Zannad Patrick Rossignol Patrick Rossignol Patrick Rossignol Pierre-Yves Marie Pierre-Yves Marie Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort |
| description |
Introduction: This study aims to assess the changes in cardiovascular remodeling attributable to bodyweight gain in a middle-aged abdominal obesity cohort. A remodeling worsening might explain the increase in cardiovascular risk associated with a dynamic of weight gain.Methods: Seventy-five middle-aged subjects (56 ± 5 years, 38 women) with abdominal obesity and no known cardiovascular disease underwent MRI-based examinations at baseline and at a 6.1 ± 1.2-year follow-up to monitor cardiovascular remodeling and hemodynamic variables, most notably the effective arterial elastance (Ea). Ea is a proxy of the arterial load that must be overcome during left ventricular (LV) ejection, with increased EA resulting in concentric LV remodeling.Results: Sixteen obese subjects had significant weight gain (>7%) during follow-up (WG+), whereas the 59 other individuals did not (WG–). WG+ and WG– exhibited significant differences in the baseline to follow-up evolutions of several hemodynamic parameters, notably diastolic and mean blood pressures (for mean blood pressure, WG+: +9.3 ± 10.9 mmHg vs. WG–: +1.7 ± 11.8 mmHg, p = 0.022), heart rate (WG+: +0.6 ± 9.4 min−1 vs. −8.9 ± 11.5 min−1, p = 0.003), LV concentric remodeling index (WG: +0.08 ± 0.16 g.mL−1 vs. WG−: −0.02 ± 0.13 g.mL−1, p = 0.018) and Ea (WG+: +0.20 ± 0.28 mL mmHg−1 vs. WG−: +0.01 ± 0.30 mL mmHg−1, p = 0.021). The evolution of the LV concentric remodeling index and Ea were also strongly correlated in the overall obese population (p < 0.001, R2 = 0.31).Conclusions: A weight gain dynamic is accompanied by increases in arterial load and load-related concentric LV remodeling in an isolated abdominal obesity cohort. This remodeling could have a significant impact on cardiovascular risk. |
| format |
article |
| author |
Damien Mandry Damien Mandry Nicolas Girerd Nicolas Girerd Nicolas Girerd Zohra Lamiral Olivier Huttin Olivier Huttin Laura Filippetti Emilien Micard Marie-Paule Bernadette Ncho Mottoh Philip Böhme Denis Chemla Denis Chemla Faïez Zannad Faïez Zannad Faïez Zannad Patrick Rossignol Patrick Rossignol Patrick Rossignol Pierre-Yves Marie Pierre-Yves Marie |
| author_facet |
Damien Mandry Damien Mandry Nicolas Girerd Nicolas Girerd Nicolas Girerd Zohra Lamiral Olivier Huttin Olivier Huttin Laura Filippetti Emilien Micard Marie-Paule Bernadette Ncho Mottoh Philip Böhme Denis Chemla Denis Chemla Faïez Zannad Faïez Zannad Faïez Zannad Patrick Rossignol Patrick Rossignol Patrick Rossignol Pierre-Yves Marie Pierre-Yves Marie |
| author_sort |
Damien Mandry |
| title |
Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort |
| title_short |
Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort |
| title_full |
Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort |
| title_fullStr |
Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort |
| title_full_unstemmed |
Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort |
| title_sort |
arterial and cardiac remodeling associated with extra weight gain in an isolated abdominal obesity cohort |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/1a0862e962fd42bfbb5e729d0be1ac2c |
| work_keys_str_mv |
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